Dynamic Edematous Response of the Human Heart to Myocardial Infarction

Fernández‐Jiménez, Rodrigo; Barreiro-Pérez, Manuel; Martin-García, Ana; Sánchez‐González, Javier; Agüero, Jaume; Galán‐Arriola, Carlos; García‐Prieto, Jaime; Díaz-Peláez, Elena; Vara, Pedro; Martinez, I. Dominguez; Zamarro, Ivan; Garde, Beatriz; Sanz, Javier; Fuster, Valentín; Sánchez, Pedro L.; Ibáñez, Borja

doi:10.1161/circulationaha.116.025582

Cited by 111 publications

(48 citation statements)

References 49 publications

(96 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the same animals were not serially scanned. Most recently, Fernandez-Jimenez and colleagues 13 showed that the bimodal edematous response of the infarct related territory was present in humans as well. However, they used the less robust T2-weighted imaging modality instead for both quantifying the extent of the edema-based area-at-risk and for detecting intramyocardial hemorrhage.…”

Section: Current Controversies In Cmr Imaging Of Stemi Patientsmentioning

confidence: 97%

“…There is currently no consensus on the optimal timing for performing the acute CMR scan although 3–5 days 6 and 4–7 days 13 post-PPCI have been proposed.…”

Section: Current Controversies In Cmr Imaging Of Stemi Patientsmentioning

confidence: 99%

“…With the recent availability of native T1, T2, T2* and post-contrast T1-mapping (to derive extracellular volume fraction [ECV] mapping) 11 , more in-depth insights can be obtained into the pathophysiological processes such as the evolution of myocardial edema in the first week post-STEMI 12, 13 , the chronic manifestation of intramyocardial hemorrhage, and its prognostic significance over microvascular obstruction 14, 15 and changes in the remote myocardial interstitial space in those developing adverse LV remodeling 16, 17 following STEMI. In this article, we provide an overview of some of the recent advances in CMR imaging in reperfused STEMI patients, discuss the recent controversies surrounding its use, and explore future applications of CMR in this setting.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cardiovascular Magnetic Resonance in Acute ST-Segment–Elevation Myocardial Infarction

et al. 2018

View full text Add to dashboard Cite

While mortality following ST-segment elevation myocardial infarction (STEMI) is on the decline, the number of patients developing heart failure due to prior myocardial infarction (MI) is on the rise. Apart from timely reperfusion by primary percutaneous coronary intervention (PPCI), there is currently no established therapy for reducing MI size. As such new cardioprotective therapies are required to improve clinical outcomes following STEMI. Cardiovascular magnetic resonance (CMR) has emerged as an important imaging modality for assessing the efficacy of novel therapies for reducing MI size and preventing subsequent adverse left ventricular remodeling. The recent availability of multi-parametric mapping CMR has provided new insights into the pathophysiology underlying myocardial edema, microvascular obstruction, intramyocardial hemorrhage, and changes in the remote myocardial interstitial space following STEMI. In this article, we provide an overview of the recent advances in CMR imaging in reperfused STEMI patients, discuss the controversies surrounding its use, and explore future applications of CMR in this setting.

show abstract

Section: Current Controversies In Cmr Imaging Of Stemi Patientsmentioning

confidence: 97%

“…There is currently no consensus on the optimal timing for performing the acute CMR scan although 3–5 days 6 and 4–7 days 13 post-PPCI have been proposed.…”

Section: Current Controversies In Cmr Imaging Of Stemi Patientsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cardiovascular Magnetic Resonance in Acute ST-Segment–Elevation Myocardial Infarction

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The timing of post-reperfusion CMR scans remains an important issue. Most CMR parameters of myocardial function and infarct severity change significantly over time [143][144][145][146]. Therefore, performing CMR very early after PCI (Day 1) leads to a considerable overestimation of IS because of edema and partial volume effect [147].…”

Section: Remaining Challenges and Opportunitiesmentioning

confidence: 99%

Role of Cardiac Magnetic Resonance to Improve Risk Prediction following Acute ST-elevation Myocardial Infarction

Reindl

Eitel

Reinstadler

2020

JCM

View full text Add to dashboard Cite

Cardiac magnetic resonance (CMR) imaging allows comprehensive assessment of myocardial function and tissue characterization in a single examination after acute ST-elevation myocardial infarction. Markers of myocardial infarct severity determined by CMR imaging, especially infarct size and microvascular obstruction, strongly predict recurrent cardiovascular events and mortality. The prognostic information provided by a comprehensive CMR analysis is incremental to conventional risk factors including left ventricular ejection fraction. As such, CMR parameters of myocardial tissue damage are increasingly recognized for optimized risk stratification to further ameliorate the burden of recurrent cardiovascular events in this population. In this review, we provide an overview of the current impact of CMR imaging on optimized risk assessment soon after acute ST-elevation myocardial infarction.

show abstract

“…The interpretation of oedema in MI during life is considered as complicated and controversial today. An initial wave of oedema appears abruptly at reperfusion, significantly attenuated by 24 h and then followed by a second healing-related wave of oedema several days after reperfusion [75]. Post-mortem radiological evaluation of ischemic myocardium is extremely challenging.…”

Section: Resuscitationmentioning

confidence: 99%

Diagnosis of myocardial infarction at autopsy: AECVP reappraisal in the light of the current clinical classification

et al. 2019

View full text Add to dashboard Cite

Ischemic heart disease is one of the leading causes of morbidity and death worldwide. Consequently, myocardial infarctions are often encountered in clinical and forensic autopsies, and diagnosis can be challenging, especially in the absence of an acute coronary occlusion. Precise histopathological identification and timing of myocardial infarction in humans often remains uncertain while it can be of crucial importance, especially in a forensic setting when third person involvement or medical responsibilities are in question. A proper post-mortem diagnosis requires not only up-to-date knowledge of the ischemic coronary and myocardial pathology, but also a correct interpretation of such findings in relation to the clinical scenario of the deceased. For these reasons, it is important for pathologists to be familiar with the different clinically defined types of myocardial infarction and to discriminate myocardial infarction from other forms of myocardial injury. This article reviews present knowledge and postmortem diagnostic methods, including post-mortem imaging, to reveal the different types of myocardial injury and the clinicalpathological correlations with currently defined types of myocardial infarction.

show abstract

Dynamic Edematous Response of the Human Heart to Myocardial Infarction

Abstract: Supplemental Digital Content is available in the text.

Cited by 111 publications

References 49 publications

Cardiovascular Magnetic Resonance in Acute ST-Segment–Elevation Myocardial Infarction

Cardiovascular Magnetic Resonance in Acute ST-Segment–Elevation Myocardial Infarction

Role of Cardiac Magnetic Resonance to Improve Risk Prediction following Acute ST-elevation Myocardial Infarction

Diagnosis of myocardial infarction at autopsy: AECVP reappraisal in the light of the current clinical classification

Contact Info

Product

Resources

About