Dynamic Distribution of Infectious Pancreatic Necrosis Virus (IPNV) Strains of Genogroups 1, 5, and 7 after Intraperitoneal Administration in Rainbow Trout (Oncorhynchus mykiss)

Abstract

Infectious pancreatic necrosis virus (IPNV) is the causative agent of rainbow trout (Oncorhynchus mykiss) IPN and causes significant loss of fingerlings. The currently prevalent IPNV genogroups in China are genogroups 1 and 5. However, in this study, we isolated and identified a novel IPNV, IPNV-P202019, which belonged to genogroup 7. Here, a total of 200 specific-pathogen-free rainbow trout (10 g average weight) were divided randomly into four groups to investigate the distribution of different IPNV strains (genogroups 1, 5, and 7) in 9 tissues of rainbow trout by means of intraperitoneal (ip) injection. Fish in each group were monitored after 3-, 7-, 14-, 21- and 28- days post-infection (dpi). The study showed no mortality in all groups. The distribution of IPNV genogroups 1 and 5 was similar in different tissues and had a higher number of viral loads after 3, 7, or 14 dpi. However, the distribution of IPNV genogroup 7 was detected particularly in the spleen, head kidney, and feces and had a lower number of viral loads. The results of this study provide valid data for the distribution of IPNV in rainbow trout tissues and showed that IPNV genogroups 1 and 5 were still the prevalent genogroups of IPNV in China. Although rainbow trout carried IPNV genogroup 7, the viral load was too low to be pathogenic.

Infeksi Virus yang Mengancam Budidaya Ikan di Indonesia

“…Meskipun upaya intensif, hasil uji coba vaksin terhadap IPNV sampai saat ini sangat bervariasi. Dengan demikian, strategi saat ini menggabungkan peningkatan peternakan dan transfer dengan seleksi untuk resistansi IPN, berdasarkan pengujian dengan paparan lapangan dalam kondisi komersial, kemungkinan akan mewakili harapan terbaik untuk pengendalian penyakit serius ini di masa depan (Shao et al, 2022).…”

Characterization of a Novel Infectious Pancreatic Necrosis Virus (IPNV) from Genogroup 6 Identified in Sea Trout (Salmo trutta) from Lake Vänern, Sweden

“…To date, seven different genogroups have been described, showing a large variability in pathogenicity, with genogroup 5 being the most virulent IPNV in all species of salmonids [ 3 ]. Comparative studies of pathogenicity are available in rainbow trout, for example, for genogroup 2, 5, and 6 [ 4 ], as well as 1, 5, and 7 [ 5 ]. In both studies, the genogroup 5 isolate caused the highest mortalities.…”