Dynamic CT perfusion imaging of intra-axial brain tumours: differentiation of high-grade gliomas from primary CNS lymphomas

Dynamic perfusion CT in brain tumors

“…Primary brain lymphomas, brain metastases, and HGGs are malignant lesions that can appear similar to each other on MR images. HGGs showed significantly higher BV and BF than primary brain lymphomas, suggesting PCT may have utility in differentiating the two entities [22,28]. However, Fainardi et al showed that there was no significant difference in tumor BV and PS between HGGs and metastases [16].…”

Imaging Techniques in Brain Tumor

“…Therefor, perfusion imaging is often useful to establish the diagnosis of tumor and to distinguish tumor from tumor mimics, for example, infective granulomas or tumefactive demyelination, which are hypoperfused with low values of CBV, CBF, and MTT. Perfusion computed tomography (PCT) allows to reliably classify gliomas and lymphomas based on quantitative measurements of CBV and KTrans (Schramm, et al 2010）. In comparison with normal parenchyma, low grade gliomas showed no significant difference of perfusion parameters, whereas high-grade gliomas demonstrated significantly higher values for KTrans, CBV and CBF.…”

“…MR perfusion imaging can also be used to identify with tumor recurrence or focal necrotic after treatment and evaluate prognosis or monitor the efficacy of treatment. Furthermore, numerous studies (Park et al, 2009;Schramm et al, 2010;Ludemann et al, 2009;Park et al, 2009) have shown that perfusion imaging have special superiority in noninvasively grading tumor histology preoperatively. Low-grade astrocytomas are hypoperfused as compared to grade III and IV lesions ( Figure 6-3).…”

“…A 58-year-old man with histopathological diagnosis of glioblastoma multiforme WHO IV. Axial contrast-enhanced MIP reconstruction image (a) shows a contrast-enhanced mass, which demonstrates intensely elevated blood flow (b) and volume (c) as well as strongly increased regional Ktrans (d) in comparison with the normal cortical and subcortical cerebral parenchyma (Schramm, et al 2010). (Schramm, et al, 2010).…”

“…Axial contrast-enhanced MIP reconstruction image (a) shows a contrast-enhanced mass, which demonstrates intensely elevated blood flow (b) and volume (c) as well as strongly increased regional Ktrans (d) in comparison with the normal cortical and subcortical cerebral parenchyma (Schramm, et al 2010). (Schramm, et al, 2010). MR perfusion can help distinguish gliomas from nonglial lesions like lymphoma and metastases or extra-axial tumors like meningioma.…”