Dynamic cross-linking of an alginate–acrylamide tough hydrogel system: time-resolved<i>in situ</i>mapping of gel self-assembly

Pragya, Akanksha; Mutalik, Suhas; Younas, Muhammad Waseem; Pang, Siu-Kwong; So, Pui‐Kin; Wang, Faming; Zheng, Zijian; Noor, Nuruzzaman

doi:10.1039/d0ra09210j

Cited by 27 publications

(29 citation statements)

References 171 publications

(116 reference statements)

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“…[ 25 ] A highly entangled hydrogel matrix likely facilitates chitosan chain entanglement within the matrix to form an interpenetrating network. [ 26 ] This possibility is supported by the strong positive linear correlation between alginate MW and adhesion strength. Thus, we show that by using high‐MW alginate in the dissipative matrix the adhesion can be significantly increased, to values even higher than what has been previously reported with a similar tough hydrogel system relying on covalent bond formation.…”

Section: Discussionmentioning

confidence: 96%

Rapid Ultratough Topological Tissue Adhesives

Cruz

Lee

Johnson³

et al. 2022

Advanced Materials

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Tissue adhesives capable of achieving strong and tough adhesion in permeable wet environments are useful in many biomedical applications. However, adhesion generated through covalent bond formation directly with the functional groups of tissues (i.e., COOH and NH2 groups in collagen), or using non‐covalent interactions can both be limited by weak, unstable, or slow adhesion. Here, it is shown that by combining pH‐responsive bridging chitosan polymer chains and a tough hydrogel dissipative matrix one can achieve unprecedented ultratough adhesion to tissues (>2000 J m−2) in 5–10 min without covalent bond formation. The strong non‐covalent adhesion is shown to be stable under physiologically relevant conditions and strongly influenced by chitosan molecular weight, molecular weight of polymers in the matrix, and pH. The adhesion mechanism relies primarily on the topological entanglement between the chitosan chains and the permeable adherends. To further expand the applicability of the adhesives, adhesion time can be decreased by dehydrating the hydrogel matrix to facilitate rapid chitosan interpenetration and entanglement (>1000 J m−2 in ≤1 min). The unprecedented adhesive properties presented in this study open opportunities for new strategies in the development of non‐covalent tissue adhesives and numerous bioapplications.

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Section: Discussionmentioning

confidence: 96%

Rapid Ultratough Topological Tissue Adhesives

Cruz

Lee

Johnson³

et al. 2022

Advanced Materials

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“…However, excess SDS can drive the morphological transitions of surfactant micelles, which can induce excessive ionic complexation. Unlike the transfer of high stress between adjacent alginate blocks in the process of unzipping, the ionic complexation formed between the sulfate group of SDS and cations cannot dissipate energy, consequently leading to a brittle hydrogel, accompanied by the decrease of strength . It is worth noting that partial samples after immersion in saline cannot be crushed, and thus, only the compressive strength at 90% strain can be provided, which is represented by dotted circles (Figure f).…”

Section: Results and Discussionmentioning

confidence: 99%

“…Unlike the transfer of high stress between adjacent alginate blocks in the process of unzipping, the ionic complexation formed between the sulfate group of SDS and cations cannot dissipate energy, consequently leading to a brittle hydrogel, accompanied by the decrease of strength. 45 It is worth noting that partial samples after immersion in saline cannot be crushed, and thus, only the compressive strength at 90% strain can be provided, which is represented by dotted circles (Figure 2f). Eventually, it was found that the compressive strength of the OMA 2 -PAAm/Alg/PDA hydrogel with MBAm 1.0% was the highest among all the measured samples after immersion.…”

Section: Mechanical Testmentioning

confidence: 99%

High-Strength Hydrogel Adhesive Formed via Multiple Interactions for Persistent Adhesion under Saline

Min

Dai

et al. 2021

ACS Appl. Bio Mater.

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Hydrogel adhesives have been widely used in wet environments. Nonetheless, strong and stable persistent adhesion remains a challenge. Here, we report a facile yet powerful strategy to construct high-strength hydrogel adhesives for durable adhesion in a saline environment. Such a hydrogel consists of two polymer networks: a hydrophobic-associated polyacrylamide network of covalent and noncovalent cross-links and an alginate network cross-linked by divalent cations in saline. Meanwhile, polydopamine nanoparticles formed through in-situ self-polymerization are distributed evenly throughout the system to provide underwater adhesion. A low and controllable swelling rate and high compressive strength of hydrogels can be achieved via this multiple interaction strategy. Ultimately, this strategy contributes to the persistent underwater adhesion of hydrogels, and the decreasing rate of lap-shear adhesion strength of hydrogels is only 24.79 ± 8.01% after saline immersion for up to 21 days. Moreover, good cytocompatibility of hydrogels is helpful for their application in the biomedical field.

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“…Gelation of alginates requires a sufficient G residue content of a minimum 20–25% ( Khotimchenko et al, 2001 ). While the ratio of M to G residues is positively correlated with the production of more elastic alginate gels, the reverse of this ratio correlates with the production of stiffer gels ( Pragya et al, 2021 ).…”

Section: Chemistry and Physicochemical Properties Of Alginatementioning

confidence: 99%

Applications of Alginate-Based Nanomaterials in Enhancing the Therapeutic Effects of Bee Products

Al-Hatamleh

Alshaer

Hatmal

et al. 2022

Front. Mol. Biosci.

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Since the ancient times, bee products (i.e., honey, propolis, pollen, bee venom, bee bread, and royal jelly) have been considered as natural remedies with therapeutic effects against a number of diseases. The therapeutic pleiotropy of bee products is due to their diverse composition and chemical properties, which is independent on the bee species. This has encouraged researchers to extensively study the therapeutic potentials of these products, especially honey. On the other hand, amid the unprecedented growth in nanotechnology research and applications, nanomaterials with various characteristics have been utilized to improve the therapeutic efficiency of these products. Towards keeping the bee products as natural and non-toxic therapeutics, the green synthesis of nanocarriers loaded with these products or their extracts has received a special attention. Alginate is a naturally produced biopolymer derived from brown algae, the desirable properties of which include biodegradability, biocompatibility, non-toxicity and non-immunogenicity. This review presents an overview of alginates, including their properties, nanoformulations, and pharmaceutical applications, placing a particular emphasis on their applications for the enhancement of the therapeutic effects of bee products. Despite the paucity of studies on fabrication of alginate-based nanomaterials loaded with bee products or their extracts, recent advances in the area of utilizing alginate-based nanomaterials and other types of materials to enhance the therapeutic potentials of bee products are summarized in this work. As the most widespread and well-studied bee products, honey and propolis have garnered a special interest; combining them with alginate-based nanomaterials has led to promising findings, especially for wound healing and skin tissue engineering. Furthermore, future directions are proposed and discussed to encourage researchers to develop alginate-based stingless bee product nanomedicines, and to help in selecting suitable methods for devising nanoformulations based on multi-criteria decision making models. Also, the commercialization prospects of nanocomposites based on alginates and bee products are discussed. In conclusion, preserving original characteristics of the bee products is a critical challenge in developing nano-carrier systems. Alginate-based nanomaterials are well suited for this task because they can be fabricated without the use of harsh conditions, such as shear force and freeze-drying, which are often used for other nano-carriers. Further, conjunction of alginates with natural polymers such as honey does not only combine the medicinal properties of alginates and honey, but it could also enhance the mechanical properties and cell adhesion capacity of alginates.

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Dynamic cross-linking of an alginate–acrylamide tough hydrogel system: time-resolvedin situmapping of gel self-assembly

Abstract: In situ, time-resolved characterisation of an alginate–acrylamide tough hydrogel dynamic formation process indicate routes to intervention and modification of chemo-physico-mechanical properties.

Cited by 27 publications

References 171 publications

Rapid Ultratough Topological Tissue Adhesives

Rapid Ultratough Topological Tissue Adhesives

High-Strength Hydrogel Adhesive Formed via Multiple Interactions for Persistent Adhesion under Saline

Applications of Alginate-Based Nanomaterials in Enhancing the Therapeutic Effects of Bee Products

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