“…Modern high-throughput experimentation (HTE) equipment makes this an easy task, but the bottleneck is the reaction analysis which generally entails tedious product purification steps and subsequent chromatographic ee determination by processing one reaction at a time. Anslyn, [162][163][164][165][166] Arai, [167,168] Biedermann, [44] Jiang, [46,47] Joyce, [169] Wolf [65,131,161,[170][171][172] and others have demonstrated how chiroptical sensing can resolve this analytical holdup, often by directly applying crude asymmetric reaction mixtures into their assays. [173] In one of the early examples of asymmetric reaction analysis, the Brønsted/Lewis acid 98 was applied to the chlorodiisopinocampheylborane mediated reduction of phenylglyoxlic acid, 99, to mandelic acid, 100.…”