Dynamic covalent bonds in self-healing, shape memory, and controllable stiffness hydrogels

Perera, M. Mario; Ayres, Neil

doi:10.1039/c9py01694e

Cited by 190 publications

(135 citation statements)

References 172 publications

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“…Supramolecular materials based on non-covalent interactions are of great interest for a wide range of biomedical applications owing to their unique properties such as stimuli-responsive gel/sol transition, toughness, easy processability, and shaping. [1][2][3][4][5] In the last decade, several studies have been aimed at developing multifunctional supramolecular materials inspired by living organisms. 6 For example, the outstanding underwater properties of marine mussel have driven a field of mussel-inspired catechol chemistry of great significance in biomaterials science and engineering.…”

Section: Introductionmentioning

confidence: 99%

Unraveling the gallol-driven assembly mechanism of thermoreversible supramolecular hydrogels inspired by ascidians

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Unraveling the gallol-driven assembly mechanism of thermoreversible supramolecular hydrogels inspired by ascidians

et al. 2020

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“…[115] Due to the strength of the covalent bonds that are formed, these hydrogels have better stability than hydrogels crosslinked via noncovalent interactions. [116] Recently, Schiff base formation has become one of the most commonly used method for synthesizing pH-responsive injectable and self-healing hydrogels. Schiff bases or imines, formed from condensation reactions between aldehydes and nucleophilic amines, display pH-sensitivity and reversibility in mildly acidic environments.…”

Section: Ph-responsive Injectable Hydrogels For Controlled and Local mentioning

confidence: 99%

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Rizzo

Kehr

2020

Adv Healthcare Materials

199

152

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Injectable hydrogels have received considerable interest in the biomedical field due to their potential applications in minimally invasive local drug delivery, more precise implantation, and site‐specific drug delivery into poorly reachable tissue sites and into interface tissues, where wound healing takes a long time. Injectable hydrogels, such as in situ forming and/or shear‐thinning hydrogels, can be generated using chemically and/or physically crosslinked hydrogels. Yet, for controlled and local drug delivery applications, the ideal injectable hydrogel should be able to provide controlled and sustained release of drug molecules to the target site when needed and should limit nonspecific drug molecule distribution in healthy tissues. Thus, such hydrogels should sense the environmental changes that arise in disease states and be able to release the optimal amount of drug over the necessary time period to the target region. To address this, researchers have designed stimuli‐responsive injectable hydrogels. Stimuli‐responsive hydrogels change their shape or volume when they sense environmental stimuli, e.g., pH, temperature, light, electrical signals, or enzymatic changes, and deliver an optimal concentration of drugs to the target site without affecting healthy tissues.

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“…Furthermore, treatments that require implantation (such as the insulin-resistance and liver disease treatment platforms discussed above) are limited in scope to settings that have at least some degree of hospital access. Integration with delivery mechanisms more conducive to limited-resource settings, such as encapsulation in injectable polymer systems utilizing dynamic covalent bonds 161 enabling cell-laden gels to transition to a solution phase during injection and reassemble inside the body, could expand applicability to additional outside-the-lab settings.…”

Section: Closed-loop Living Therapeutics and Probiotic Deliverymentioning

confidence: 99%

Applications, challenges, and needs for employing synthetic biology beyond the lab

2021

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Synthetic biology holds great promise for addressing global needs. However, most current developments are not immediately translatable to ‘outside-the-lab’ scenarios that differ from controlled laboratory settings. Challenges include enabling long-term storage stability as well as operating in resource-limited and off-the-grid scenarios using autonomous function. Here we analyze recent advances in developing synthetic biological platforms for outside-the-lab scenarios with a focus on three major application spaces: bioproduction, biosensing, and closed-loop therapeutic and probiotic delivery. Across the Perspective, we highlight recent advances, areas for further development, possibilities for future applications, and the needs for innovation at the interface of other disciplines.

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Dynamic covalent bonds in self-healing, shape memory, and controllable stiffness hydrogels

Abstract: A review of hydrogels containing dynamic bonds that are shown to provide benefits for applications including self-healing and stimuli-induced stiffness changes.

Cited by 190 publications

References 172 publications

Unraveling the gallol-driven assembly mechanism of thermoreversible supramolecular hydrogels inspired by ascidians

Unraveling the gallol-driven assembly mechanism of thermoreversible supramolecular hydrogels inspired by ascidians

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Applications, challenges, and needs for employing synthetic biology beyond the lab

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