Dynamic coordination of the perirhinal cortical neurons supports coherent representations between task epochs

Ohnuki, Tomoya; Osako, Yuma; Manabe, Hiroyuki; Sakurai, Yoshio; Hirokawa, Junya

doi:10.1038/s42003-020-01129-3

Cited by 12 publications

(10 citation statements)

References 72 publications

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“…The surgical procedures were almost identical to those reported in previous studies ( Ohnuki et al, 2020 ; Osako et al, 2021 ; Takamiya et al, 2021 ). Rats were anesthetized with 2.5% isoflurane before surgery, which was maintained throughout the surgical procedure.…”

Section: Methodssupporting

confidence: 54%

Auditory Cortex Neurons Show Task-Related and Learning-Dependent Selectivity toward Sensory Input and Reward during the Learning Process of an Associative Memory Task

Takamiya

Shiotani

Ohnuki

et al. 2022

eNeuro

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The activity of primary auditory cortex (A1) neurons is modulated not only by sensory inputs but also by other task-related variables in associative learning. However, it is unclear how A1 neural activity changes dynamically in response to these variables during the learning process of associative memory tasks. Therefore, we developed an associative memory task using auditory stimuli in rats. In this task, rats were required to associate tone frequencies (high and low) with a choice of ports (right or left) to obtain a reward. The activity of A1 neurons in the rats during the learning process of the task was recorded. A1 neurons increased their firing rates either when the rats were presented with a high or low tone (frequency-selective cells) before they chose either the left or right port (choice-direction cells), or when they received a reward after choosing either the left or right port (reward-direction cells). Furthermore, the proportion of frequency-selective cells and reward-direction cells increased with task acquisition and reached the maximum level in the last stage of learning. These results suggest that A1 neurons have task- and learning-dependent selectivity toward sensory input and reward when auditory tones and behavioral responses are gradually associated during task training. This selective activity of A1 neurons may facilitate the formation of associations, leading to the consolidation of associative memory.

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Section: Methodssupporting

confidence: 54%

Auditory Cortex Neurons Show Task-Related and Learning-Dependent Selectivity toward Sensory Input and Reward during the Learning Process of an Associative Memory Task

Takamiya

Shiotani

Ohnuki

et al. 2022

eNeuro

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Section: Discussionmentioning

confidence: 99%

“…Neurons coding a behavioral response were previously reported in the PER and POR when animals were required to produce an associated behavior based on a stimulus ( Furtak et al, 2012 ; Ahn and Lee, 2015 ; Bos et al, 2017 ; Ohnuki et al, 2020 ). Those response-related firings were present even when the associated stimuli were from different sensory modalities ( Ohnuki et al, 2020 ). Our previous study showed that the emergence of response coding was not confined to a time point at which animals were actually moving their muscles to produce a certain choice response ( Ahn and Lee, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

The Interaction of Cue Type and Its Associated Behavioral Response Dissociates the Neural Activity between the Perirhinal and Postrhinal Cortices

Lim

Ahn

Lee

2022

eNeuro

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The perirhinal cortex (PER) and postrhinal cortex (POR) in the medial temporal lobe are commonly described as two distinct systems that process nonspatial and spatial information, respectively. Recent findings suggest that the two regions exhibit functional overlap when processing stimulus information, especially when associative responses are required in goal-directed behavior. However, we lack the neural correlates of this. In the current study, we recorded spiking activities for single units of the PER and POR as rats were required to choose a response associated with the identity of a visual object or scene stimulus. We found that similar proportions of cells fired selectively for either scene or object between the two regions. In the PER and POR, response-selective neurons showed higher contrast for different responses than stimulus-selective cells did for stimuli. More cells fired selectively for specific choice response in the POR than in the PER. The differential firing patterns of the PER and POR were best explained when the stimulus and response components were considered together: Stimulus-selective cells were modulated more by the response in the POR than in the PER, whereas response-selective cells in the PER were modulated more by object information than by scenes. Our results suggest that in a goal-directed memory task, the information processing in the PER and POR may be dynamically modulated not only by input stimulus information but also by the associated choice behavior and stimulus–response interaction.

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“…The surgical procedure was almost identical to that of previous studies (Ohnuki et al, 2020;Osako et al, 2021). Rats were anesthetized with 2.5% isoflurane before surgery and were maintained throughout the surgical procedure.…”

Section: Surgerymentioning

confidence: 99%

Hippocampal CA1 Neurons Represent Positive Feedback During the Learning Process of an Associative Memory Task

Takamiya

Shiotani

Ohnuki

et al. 2021

Front. Syst. Neurosci.

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The hippocampus is crucial for forming associations between environmental stimuli. However, it is unclear how neural activities of hippocampal neurons dynamically change during the learning process. To address this question, we developed an associative memory task for rats with auditory stimuli. In this task, the rats were required to associate tone pitches (high and low) and ports (right and left) to obtain a reward. We recorded the firing activity of neurons in rats hippocampal CA1 during the learning process of the task. As a result, many hippocampal CA1 neurons increased their firing rates when the rats received a reward after choosing either the left or right port. We referred to these cells as “reward-direction cells.” Furthermore, the proportion of the reward-direction cells increased in the middle-stage of learning but decreased after the completion of learning. This result suggests that the activity of reward-direction cells might serve as “positive feedback” signal that facilitates the formation of associations between tone pitches and port choice.

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Dynamic coordination of the perirhinal cortical neurons supports coherent representations between task epochs

Cited by 12 publications

References 72 publications

Auditory Cortex Neurons Show Task-Related and Learning-Dependent Selectivity toward Sensory Input and Reward during the Learning Process of an Associative Memory Task

Auditory Cortex Neurons Show Task-Related and Learning-Dependent Selectivity toward Sensory Input and Reward during the Learning Process of an Associative Memory Task

The Interaction of Cue Type and Its Associated Behavioral Response Dissociates the Neural Activity between the Perirhinal and Postrhinal Cortices

Hippocampal CA1 Neurons Represent Positive Feedback During the Learning Process of an Associative Memory Task

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