Dynamic control of needle-free jet injection

Stachowiak, Jeanne C.; Li, Thomas H.; Arora, Anubhav; Mitragotri, Samir; Fletcher, Daniel A.

doi:10.1016/j.jconrel.2009.01.003

Cited by 115 publications

(67 citation statements)

References 30 publications

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“…The move to inkjet printing promises to improve monodispersity and provide bettter control of dosage volume. An additional method for drug delivery is being explored, where special jetforming techniques are used to produce supersonic jets of the API to penetrate the dermis layer and create needle-free injection techniques (Stachowiak et al 2009, Hemond et al 2011. Very high jet velocities have been achieved but such techniques are still under development.…”

Section: Final Drug Delivery Methodsmentioning

confidence: 99%

Inkjet printing for pharmaceutics – A review of research and manufacturing

Daly

Harrington

Martin

et al. 2015

International Journal of Pharmaceutics

261

185

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Abstract:Global regulatory, manufacturing and consumer trends are driving a need for change in current pharmaceutical sector business models, with a specific focus on the inherently expensive research costs, high-risk capital-intensive scale-up and the traditional centralised batch manufacturing paradigm. New technologies, such as inkjet printing, are being explored to radically transform pharmaceutical production processing and the end-to-end supply chain. This review provides a brief summary of inkjet printing technologies and their current applications in manufacturing before examining the business context driving the exploration of inkjet printing in the pharmaceutical sector. We then examine the trends reported in the literature for pharmaceutical printing, followed by the scientific considerations and challenges facing the adoption of this technology. We demonstrate that research activities are highly diverse, targeting a broad range of pharmaceutical types and printing systems. To mitigate this complexity we show that by categorising findings in terms of targeted business models and Active Pharmaceutical Ingredient (API) chemistry we have a more coherent approach to comparing research findings and can drive efficient translation of a chosen drug to inkjet manufacturing.

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Section: Final Drug Delivery Methodsmentioning

confidence: 99%

Inkjet printing for pharmaceutics – A review of research and manufacturing

Daly

Harrington

Martin

et al. 2015

International Journal of Pharmaceutics

261

185

View full text Add to dashboard Cite

show abstract

“…Though its small jet diameter potentially makes jet injection less invasive than the 640 μm diameter of conventional 23G hypodermic needles, this needle-free injection method has not gained wide acceptance yet [1,[3][4][5]. This limited acceptance primarily stems from the common pain and bruising induced by uncontrolled injection depth and liquid dispersion into skin or tissue.…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, many existing springand gas-actuated jet injectors operate at a single velocity, usually between 100 and 200 m/s [2]. This does not allow adapting to the broad variety of mechanical properties of skin and soft tissue in the population, thus occasionally resulting in uncontrolled drug delivery into deeper layers and excitation of nerve endings [4,[6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…To improve control over the injection depth and delivered dose, several groups have recently developed needle-free jet injectors able to dynamically actuate the jet velocity [4] or jet pressure [7] during the injection. This new generation of jet injectors first produces a brief powerful jet to reach the targeted layer and then a longer jet, below the skin penetration threshold, to deliver a defined dose.…”

Section: Introductionmentioning

confidence: 99%

“…This new generation of jet injectors first produces a brief powerful jet to reach the targeted layer and then a longer jet, below the skin penetration threshold, to deliver a defined dose. These devices are based on a complete redesign of standard jet injectors to operate over a wider range of velocities (60-160 m/s) [4] or pressure (5-50 MPa) [7], which was respectively achieved with a piezo-and Lorentz-force actuator.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Depth-controlled laser-induced jet injection for direct three-dimensional liquid delivery

et al. 2018

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Needle-free jet injection enables the delivery of drugs into skin or soft tissue by puncturing them with a high-velocity liquid jet. However, precise and efficient drug delivery requires generating such liquid jets with both a controlled velocity and a high throughput, which remains challenging with current spring-and gas-actuated jet injectors. Here, we propose a depth-controlled and high-throughput injection method by adapting laser-induced forward transfer (LIFT), a high-resolution two-dimensional printing technique, for direct three-dimensional liquid delivery into soft tissues.The velocity of thin liquid jets is laser actuated from 10 to 85 m/s so that doses as small as 10 pL, not achievable with other injectors, are injected at a 1 Hz repetition rate into a 300 μm thick soft gelatin substrate with a 25 μm depth precision and 12 μm lateral resolution. We further investigate the potential of this liquid delivery technique as a direct three-dimensional cell-delivery vehicle and show that depth-controlled particle delivery requires high-delivery efficiency. Our direct three-dimensional liquid delivery system opens up more possibilities for pinpoint drug delivery in soft tissues or tissue-engineered constructs.

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Microporation for Enhanced Transdermal Drug Delivery

Singh¹,

Gujral²

2015

Novel Delivery Systems for Transdermal and Intradermal Drug Delivery

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Dynamic control of needle-free jet injection

Cited by 115 publications

References 30 publications

Inkjet printing for pharmaceutics – A review of research and manufacturing

Inkjet printing for pharmaceutics – A review of research and manufacturing

Depth-controlled laser-induced jet injection for direct three-dimensional liquid delivery

Microporation for Enhanced Transdermal Drug Delivery

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