Dynamic contrast-enhanced ultrasound (CEUS) after open and minimally invasive locked plating of proximal humerus fractures

Fischer, Christian; Frank, Marion E.; Kamtchouing, Pièrre; Tanner, Michael C.; Weber, Marc‐André; Moghaddam, Arash; Schmidmaier, Gerhard; Hug, Andreas

doi:10.1016/j.injury.2016.05.005

Cited by 32 publications

(24 citation statements)

References 44 publications

(51 reference statements)

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“…Being closely linked to the responsiveness and recruitment of muscle fibers and the muscle metabolism, CEUS has been suggested as functional real‐time biomarker for muscle vitality and function beyond morphologic aspects . Originally implemented for assistive diagnostics of liver and kidney tumors in 2004, CEUS has nowadays been translated into the clinical routine of numerous pathologies and was lately evaluated for various musculoskeletal indications, including shoulder pathologies . In reverse shoulder arthroplasty, CEUS‐based quantification of deltoid properties was significantly associated with shoulder function after reverse shoulder arthroplasty .…”

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confidence: 99%

Contrast‐Enhanced Ultrasound (CEUS) as Predictor for Early Retear and Functional Outcome After Supraspinatus Tendon Repair

Kamtchouing

Mick

Groß

et al. 2019

Journal Orthopaedic Research

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Supraspinatus (SSP) tendon tears represent a common indication for shoulder surgery. Yet, prediction of postoperative function and tendon retear remains challenging and primarily relies on morphologic magnetic resonance imaging (MRI)-based parameters, supported by patients' demographic data like age, gender, and comorbidities. Considering continuously high retear rates, especially in patients with larger tears and negative prognostic factors, improved outcome prediction could be of high clinical value. Contrastenhanced ultrasound (CEUS) enables an assessment of dynamic perfusion of the SSP muscle. As a potential surrogate for muscle vitality, CEUS might reflect functional properties of the SSP and support improved outcome prediction after tendon repair. Fifty patients with isolated SSP tendon tears were prospectively enrolled. Preoperatively, SSP muscle perfusion was quantified by CEUS and conventional morphologic parameters like tear size, fatty infiltration, and tendon retraction were assessed by MRI. At six months follow-up, shoulder function, tendon integrity, and muscle perfusion were reassessed. The predictive value of preoperative CEUS for postoperative shoulder function and tendon integrity was evaluated. 35 patients entered the statistical analysis. Preoperative CEUS-based assessment of SSP perfusion significantly correlated with early postoperative shoulder function (Constant, r = 0.48, p < 0.018) and tendon retear (r = 0.67, p < 0.001). CEUS-based subgroup analysis identified patients with exceptionally high, respectively low risk for tendon retear. CEUSbased assessment of the SSP seemed to predict early shoulder function and tendon retear after SSP repair and allowed to identify patient subgroups with exceptionally high or low risk for tendon retear.

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confidence: 99%

Contrast‐Enhanced Ultrasound (CEUS) as Predictor for Early Retear and Functional Outcome After Supraspinatus Tendon Repair

Kamtchouing

Mick

Groß

et al. 2019

Journal Orthopaedic Research

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“…Muscular CEUS studies included perioperative perfusion assessment of the deltoid muscle in patients with cuff tear arthropathy or proximal humerus fractures, that were treated with reversed shoulder arthroplasty 16 or PHILOS plating (proximal humeral internal locking system, DePuy Synthes ® , Raynham, MA, U.S.). 23 Another key aspect of muscular CEUS investigation has been the supraspinatus muscle microperfusion in patients with traumatic or degenerative supraspinatus tendon tear (Kunzet al 2019, data not yet published). 17 Strong correlations could be demonstrated between pre-and postoperative muscle perfusion with shoulder function and the risk of postoperative retear 17 (Figure 1).…”

Section: Patient Population and Study Protocolmentioning

confidence: 99%

<p>Safety Profile of Musculoskeletal Contrast-Enhanced Ultrasound with Sulfur Hexafluoride Contrast Agent</p>

Fischer¹,

Kamtchouing²,

Strauch³

et al. 2020

TCRM

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These authors contributed equally to this workPurpose: Muscle, bone and tendon regeneration depend on the microperfusion of the corresponding tissue which can be quantified with contrast-enhanced ultrasound (CEUS) using sulfur hexafluoride contrast agent (SonoVue ® ). This study investigated the incidence of adverse events (AEs) in musculoskeletal patients and gives an overview of musculoskeletal CEUS applications. Patients and Methods: Based on 13 studies in a standardized monocentric setting, a total of 2268 CEUS examinations in 764 patients were performed and AEs due to the administration of sulfur hexafluoride contrast agent were classified as either mild, moderate or severe. Results: No fatal events occurred. AEs were reported in three cases, of which only one was classified as severe and two as mild. The total rate of all AEs was 0.13% and 0.04% for severe AEs. Conclusion: The present analysis confirms the safety of musculoskeletal CEUS using sulfur hexafluoride contrast agent with a lower rate of AEs than that reported for other contrast agents even in elderly patients with concomitant diseases.

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“…were included in the meta-analysis [9,10,[15][16][17][18][19][20][21][22][23][24][25][26][27][28]. The flow diagram of the included studies is shown in Figure 1.…”

Section: Literature Searchmentioning

confidence: 99%

“…The methodological quality of the RCTs [9,27] was assessed by the Cochrane Handbook, the assessment results are summarized in Figure 2. The quality index scores of the non-RCTs [10,[15][16][17][18][19][20][21][22][23][24][25][26]28] were 14-20. The assessment results are summarized in Table 2.…”

Section: Literature Searchmentioning

confidence: 99%

Comparison between minimally invasive plate osteosynthesis and open reduction–internal fixation for proximal humeral fractures: a meta-analysis based on 1050 individuals

Nie²,

Liu

et al. 2019

Preprint

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Dynamic contrast-enhanced ultrasound (CEUS) after open and minimally invasive locked plating of proximal humerus fractures

Cited by 32 publications

References 44 publications

Contrast‐Enhanced Ultrasound (CEUS) as Predictor for Early Retear and Functional Outcome After Supraspinatus Tendon Repair

Contrast‐Enhanced Ultrasound (CEUS) as Predictor for Early Retear and Functional Outcome After Supraspinatus Tendon Repair

<p>Safety Profile of Musculoskeletal Contrast-Enhanced Ultrasound with Sulfur Hexafluoride Contrast Agent</p>

Comparison between minimally invasive plate osteosynthesis and open reduction–internal fixation for proximal humeral fractures: a meta-analysis based on 1050 individuals

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