Dynamic Contrast-Enhanced Subtraction MRI for Characterizing Intratesticular Mass Lesions

Tsili, Athina C.; Argyropoulou, Maria I.; Astrakas, Loukas G.; Ntoulia, Ekaterini A.; Giannakis, Dimitrios; Sofikitis, Nikolaos; Tsampoulas, Konstantinos

doi:10.2214/ajr.12.9064

Cited by 50 publications

(51 citation statements)

References 33 publications

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“…Although ultrasonography is the imaging modality of choice for assessing scrotal lesions, MRI can provide important diagnostic information, especially in cases of inconclusive or nondiagnostic sonographic findings 2627282930313233343536373839. DWI with evaluation of ADC has been shown to be an important diagnostic tool, providing quantitative information regarding structural tissue changes at a cellular level, which helps in tissue characterization 123456789101112.…”

Section: Discussionmentioning

confidence: 99%

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Apparent diffusion coefficient values of normal testis and variations with age

et al. 2014

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The usefulness of diffusion-weighted magnetic resonance imaging (DWI) in the evaluation of scrotal pathology has recently been reported. A standard reference of normal testicular apparent diffusion coefficient (ADC) values and their variations with age is necessary when interpreting normal testicular anatomy and pathology. We evaluated 147 normal testes using DWI, including 71 testes from 53 men aged 20–39 years (group 1), 67 testes from 42 men aged 40–69 years (group 2) and nine testes from six men older than 70 years (group 3). DWI was performed along the axial plane, using a single shot, multislice spin-echo planar diffusion pulse sequence and b-values of 0 and 900 s mm−2. The mean and standard deviation of the ADC values of normal testicular parenchyma were calculated for each age group separately. Analysis of variance (ANOVA) followed by post hoc analysis (Dunnett T3) was used for statistical purposes. The ADC values (× 10−3 mm2 s−1) of normal testicular tissue were different among age groups (group 1: 1.08 ± 0.13; group 2: 1.15 ± 0.15 and group 3: 1.31 ± 0.22). ANOVA revealed differences in mean ADC among age groups (F = 11.391, P < 0.001). Post hoc analysis showed differences between groups 1 and 2 (P = 0.008) and between groups 1 and 3 (P = 0.043), but not between groups 2 and 3 (P = 0.197). Our findings suggest that ADC values of normal testicular tissue increase with advancing age.

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Section: Discussionmentioning

confidence: 99%

“…However, imaging of the scrotum has been significantly refined during recent years 1314151617282930313233343536373839404142434445. The goal of imaging is to improve the diagnosis and management of men with acute scrotal symptoms or a palpable mass and to reduce the number of unnecessary radical surgical procedures.…”

Section: Discussionmentioning

confidence: 99%

Apparent diffusion coefficient values of normal testis and variations with age

et al. 2014

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“…Magnetic Resonance (MR) of the testis, by means of classic T1 and T2 weighted sequences, is the second level choice to study the parenchymal pattern, the vascularization and for the morphovolumetric characterization [9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Role of MR Spectroscopy (H1-MRS) of the Testis in Men with Semen Analysis Altered

Parenti¹,

Albarello²

2016

Reprod Syst Sex Disord

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Purpose: Proton magnetic resonance spectroscopy (1 H-MRS) has been proposed as a tool to assess male infertility providing metabolic signatures related to the spermatogenesis in the testis. This study sought to identify the role of 1 H-MRS in the diagnosis of infertility in patients with semen analysis altered. Materials and Methods:14 patients (27 testicles) with fertility problems and with an altered semen analysis (5 oligospermia, 3 asthenospermia, 6 oligoasthenospermia) and 9 controls (18 testicles) with normal spermatogenesis assessed (men with prior paternity and normal semen analysis) and normal testicles at magnetic resonance (MR) and ultrasonography (US) with colour Doppler (CD) examination were included. All patients underwent testis US and CD investigation, conventional MR examination at 1.5T including T1 and T2 weighted images in three orthogonal planes and proton magnetic resonance spectroscopy (1 H-MRS) with single-voxel PRESS (TR 2000 ms / TE 31 ms). Major metabolites peaks (choline, creatine, lipids, lactate) were calculated and compared between the patients and controls.Results: Mean choline peak in the semen analysis altered group was statistically significantly lower than the normal group (0.69 vs 1.34, 95% CI: 0.52 -0.85; p < 0.001). 18 testicles within semen analysis altered group (66,7%) had both MR and US examination negative but mean choline peak lower then controls (1.09 vs 1.34, p < 0.001). 7 testicles of those presented also varicocele at CD investigation. Conclusion:1 H-MRS revealed a significant shift towards lower choline peak in patients with semen analysis altered compared to controls with normal spermatogenesis. Moreover 1 HMRS provided to find out spermatogenesis disorder in patients with normal testis at MR and US examination.

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“…A subtraction algorithm performs this task to create images that can be manually adjusted in all the standard ways to suit the user [9]. Dynamic subtraction imaging has been thoroughly described in the literature [10][11][12] and is a well-established technique, particularly in MR angiography [13] and MR urography [14]. The use of subtraction as a postprocessing tool for quantitative analysis is beyond the scope of this article.…”

Section: Descriptionmentioning

confidence: 99%

Fusion and subtraction post-processing in body MRI

Watson

Olsen

2014

Pediatr Radiol

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Interpreting complex paediatric body MRI studies requires the integration of information from multiple sequences. Image processing software, some freely available, allows the radiologist to use simple and rapid post-processing techniques that may aid diagnosis. We demonstrate the use of fusion and subtraction post-processing techniques with examples from four areas of application: enterography, oncological imaging, musculoskeletal imaging and MR fistulography.

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Dynamic Contrast-Enhanced Subtraction MRI for Characterizing Intratesticular Mass Lesions

Abstract: Dynamic contrast-enhanced MRI may be used to distinguish between benign and malignant intratesticular mass lesions.

Cited by 50 publications

References 33 publications

Apparent diffusion coefficient values of normal testis and variations with age

Apparent diffusion coefficient values of normal testis and variations with age

Role of MR Spectroscopy (H1-MRS) of the Testis in Men with Semen Analysis Altered

Fusion and subtraction post-processing in body MRI

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