Dynamic contrast-enhanced perfusion MR imaging of diseased vertebrae: analysis of three parameters and the distribution of the time-intensity curve patterns

Abstract

In distinguishing osteoporotic from pathologic compression fractures, semiquantitative analysis of the perfusion MR imaging may be useful. However, the analysis of the TIC patterns can not significantly contribute to the differential diagnosis.

Quantitative imaging methods in osteoporosis

“…Quantitative outcomes of diffusion-weighted imaging and dynamic contrast-enhanced MRI have been reported to be different between acute osteoporotic vertebral fractures from normal appearing vertebrae (113). Furthermore, maximum enhancement [E(max)] and enhancement slope [E(slope)] are significantly decreased in osteoporosis in at least the femurs and vertebrae (114)(115)(116)(117)(118). Quantitative parameters of blood flow were studied with DCE-MRI in osteoporotic patients with acute vertebral fracture compared to a control group (119).…”

Characterizing Hypervascular and Hypovascular Metastases and Normal Bone Marrow of the Spine Using Dynamic Contrast-Enhanced MR Imaging

“…Many have studied the possibility of unique TICs for different pathologies, but conclusions have been equivocal, partly due to assumptions of homogeneity within the lesions. 8,9 DCE-MR imaging is currently widely established for the study of brain perfusion, including the classification of tumors such as glioblastoma multiforme. 10,11 Numerous studies reveal the potential role for DCE-MR imaging in the diagnosis, treatment, and management of diseases outside the brain as well.…”

“…5,8,9,[12][13][14][15][16] There is also evidence that perfusion studies can differentiate osteoporotic compression fractures from pathologic fractures. 8,9 Furthermore, the ability of DCE-MR imaging to monitor tumor response to chemotherapy and radiation, as well as to detect areas of viable tumor before resection, has also been described. 17,18 The potential role for DCE-MR imaging to differentiate between various types of metastatic lesions, however, has not yet been studied.…”

Proximal femur bone marrow blood perfusion indices are reduced in hypertensive rats: A dynamic contrast‐enhanced MRI study

“…At the proximal femoral shaft, a quick wash-out phenomenon similar to Tokuda et al's (17) definition was observed. In contrast, at the femoral head, after a similar rapidly rising phase, the time-signal intensity curve reached an inflection point, followed by a slowly rising phase or a prolonged plateau without significant wash-out within 8 minutes postcontrast injection (17,30). This may be attributed to differences in diffusion and clearance efficiency of contrast materials.…”