Dynamic contrast-enhanced near-infrared spectroscopy using indocyanine green on moderate and severe traumatic brain injury: a prospective observational study

Forcione, Mario; Yakoub, Kamal Makram; Chiarelli, Antonio Maria; Perpetuini, David; Sun, Rosa; Sawosz, Piotr; Belli, Antonio; Davies, David

doi:10.21037/qims-20-742

Cited by 14 publications

(21 citation statements)

References 43 publications

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“…Such pathologies include but are not limited to Alzheimer’s, 1 Parkinson’s, 2 epilepsy, 3 and traumatic brain injury. 4 , 5 Psychiatric conditions such as schizophrenia 6 and anxiety 7 have also been studied, demonstrating the benefit of this technique over conventional technologies such as fMRI, PET, and EEG. The basic principle behind fNIRS is that different constituents in biological tissue absorb and scatter near-infrared (NIR) wavelengths of light (typically 650 to 950 nm) to a varying degree based on their extinction coefficient, cellular size, and density.…”

Section: Introductionmentioning

confidence: 99%

Quantitative evaluation of frequency domain measurements in high density diffuse optical tomography

2021

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. Significance: High density diffuse optical tomography (HD-DOT) as applied in functional near-infrared spectroscopy (fNIRS) is largely limited to continuous wave (CW) data. Using a single modulation frequency, frequency domain (FD) HD-DOT has recently demonstrated better localization of focal activation as compared to CW data. We show that combining CW and FD measurements and multiple modulation frequencies increases imaging performance in fNIRS. Aim: We evaluate the benefits of multiple modulation frequencies, combining different frequencies as well as CW data in fNIRS HD-DOT. Approach: A layered model was used, with activation occurring within a cortex layer. CW and FD measurements were simulated at 78, 141, and 203 MHz with and without noise. The localization error, full width half maximum, and effective resolution were evaluated. Results: Across the average of the three metrics, at 141 MHz, FD performed 8.4% better than CW, and the combination of CW and FD was 21.7% better than CW. FD measurements at 203 MHz performed 5% better than 78 MHz. Moreover, the three combined modulation frequencies of FD and CW performed up to 3.92% better than 141 MHz alone. Conclusions: We show that combining CW and FD measurements offers better performance than FD alone, with higher modulation frequencies increasing accuracy. Combining CW and FD measurements at multiple modulation frequencies yields the best overall performance.

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Section: Introductionmentioning

confidence: 99%

Quantitative evaluation of frequency domain measurements in high density diffuse optical tomography

2021

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“…The application of NIRS in a clinical context can be hampered by multiple elements that affect the quality of the data recorded: sweat, which affects the probe–skin coupling; motion artifacts, due to involuntary movements under light sedation; ambient light–noise; poor feedback on the quality of the signal acquired during the acquisition; etc. [ 7 , 120 , 121 ].…”

Section: Intracranial Tissue Partial Oxygen Pressure and Near-infrmentioning

confidence: 99%

“…The passage of a bolus of contrast dye (i.e., ICG) through the brain can be monitored using NIRS [ 120 , 144 ]. The kinetic of the ICG can be related to cerebral perfusion and BBB integrity [ 120 , 144 ].…”

Section: Future Application Of Tissue Partial Oxygen Pressure and mentioning

confidence: 99%

Mismatch between Tissue Partial Oxygen Pressure and Near-Infrared Spectroscopy Neuromonitoring of Tissue Respiration in Acute Brain Trauma: The Rationale for Implementing a Multimodal Monitoring Strategy

Forcione

Ganau

Prisco

et al. 2021

IJMS

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The brain tissue partial oxygen pressure (PbtO2) and near-infrared spectroscopy (NIRS) neuromonitoring are frequently compared in the management of acute moderate and severe traumatic brain injury patients; however, the relationship between their respective output parameters flows from the complex pathogenesis of tissue respiration after brain trauma. NIRS neuromonitoring overcomes certain limitations related to the heterogeneity of the pathology across the brain that cannot be adequately addressed by local-sample invasive neuromonitoring (e.g., PbtO2 neuromonitoring, microdialysis), and it allows clinicians to assess parameters that cannot otherwise be scanned. The anatomical co-registration of an NIRS signal with axial imaging (e.g., computerized tomography scan) enhances the optical signal, which can be changed by the anatomy of the lesions and the significance of the radiological assessment. These arguments led us to conclude that rather than aiming to substitute PbtO2 with tissue saturation, multiple types of NIRS should be included via multimodal systemic- and neuro-monitoring, whose values then are incorporated into biosignatures linked to patient status and prognosis. Discussion on the abnormalities in tissue respiration due to brain trauma and how they affect the PbtO2 and NIRS neuromonitoring is given.

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“…This can be explained by an impairment in cerebral autoregulation, which saw the increasing ICP cause cerebral hypoperfusion (19,20) leading to a decrease in cerebral blood volume (21) brain cells require oxygen to metabolize, the more deoxyhemoglobin is produced. Forcione et al have nicely shown how this can be done with dynamic contrast-enhanced NIRS with indocyanine green in TBI patients (25,26).…”

Section: The Changes In Relative Concentrations Ofmentioning

confidence: 99%

A novel wireless optical technique for quantitative evaluation of cerebral perfusion pressure in a fluid percussion animal model of traumatic brain injury

Huang¹,

Lin²,

Wang³

et al. 2021

Quant Imaging Med Surg

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Background: Cerebral perfusion pressure (CPP) calculated by mean arterial pressure (MAP) minus intracranial pressure (ICP) is related to blood flow into the brain and reflects cerebral ischemia and oxygenation indirectly. Near-infrared spectroscopy (NIRS) can assess cerebral ischemia and hypoxia noninvasively and has been widely used in neuroscience. However, the correlation between CPP and NIRS, and its potential application in traumatic brain injury, has seldom been investigated.Methods: We used a novel wireless NIRS system and commercial ICP and MAP devices to assess the trauma to rat brains using different impact intensity. The relationship between CPP and NIRS parameters with increasing impact strength were investigated. Results:The results showed that changes in CPP (∆CPP), oxy-hemoglobin {∆[HbO 2 ]}, total-hemoglobin {∆[HbT]}, and deoxy-hemoglobin were inversely proportional to the increase in impact intensity, and the correlations between ∆CPP, NIRS parameters {∆[HbO 2 ], and ∆[HbT]} were significant.Conclusions: The NIRS system can assess cerebral ischemia and oxygenation non-invasively and changes of HbO 2 and HbT may be used as reference parameters to assess the level of CPP in an animal model of traumatic brain injury.

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Dynamic contrast-enhanced near-infrared spectroscopy using indocyanine green on moderate and severe traumatic brain injury: a prospective observational study

Cited by 14 publications

References 43 publications

Quantitative evaluation of frequency domain measurements in high density diffuse optical tomography

Quantitative evaluation of frequency domain measurements in high density diffuse optical tomography

Mismatch between Tissue Partial Oxygen Pressure and Near-Infrared Spectroscopy Neuromonitoring of Tissue Respiration in Acute Brain Trauma: The Rationale for Implementing a Multimodal Monitoring Strategy

A novel wireless optical technique for quantitative evaluation of cerebral perfusion pressure in a fluid percussion animal model of traumatic brain injury

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