Dynamic contrast‐enhanced MRI of primary rectal cancer: Quantitative correlation with positron emission tomography/computed tomography

Gu, Jin; Khong, Pek‐Lan; Wang, Silun; Chan, Queenie; Wu, Ed X.; Law, Wai‐Lun; Liu, Rico Kingyin; Zhang, Jingbo

doi:10.1002/jmri.22405

Cited by 17 publications

(9 citation statements)

References 33 publications

(44 reference statements)

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“…Whereas in our study no statistically significant correlation was seen overall between either k ep or K trans and SUVmax, a previous study of rectal cancer patient did demonstrate a significant positive correlation between k ep and SUVmax [37]. However, in a study of colorectal liver metastases, no association was seen between vascular parameters (k ep , V e , and K trans ) and glucose metabolism [38], which is concordant with our study.…”

Section: Discussionsupporting

confidence: 90%

Assessment of Aggressiveness of Breast Cancer Using Simultaneous 18F-FDG-PET and DCE-MRI

Margolis

Moy

Sigmund

et al. 2016

Clinical Nuclear Medicine

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Purpose To investigate the feasibility of using simultaneous breast MRI and PET to assess the synergy of MR pharmacokinetic and fluorine-18 fluorodeoxyglucose (18F-FDG) uptake data to characterize tumor aggressiveness in terms of metastatic burden and Ki67 status. Methods Twelve consecutive patients underwent breast and whole body PET/MRI. During the MR scan, PET events were simultaneously accumulated. MR contrast kinetic model parametric maps were computed using the extended Tofts model, including the volume transfer constant between blood plasma and the interstitial space (Ktrans), the transfer constant from the interstitial space to the blood plasma (kep), and the plasmatic volume fraction (Vp). Results Patients with systemic metastases had a significantly lower kep compared to those with local disease (0.45 vs 0.99 min−1, p=0.011). Metastatic burden correlated positively with Ktrans and standardized uptake value (SUV), and negatively with kep. Ki67 positive tumors had a significantly greater Ktrans compared to Ki67 negative tumors (0.29 vs 0.45 min−1, p=0.03). A negative correlation was found between metabolic tumor volume and transfer constant (Ktrans or Kep). Conclusion These preliminary results suggest that MR pharmacokinetic parameters and FDG-PET may aid in the assessment of tumor aggressiveness and metastatic potential. Future studies are warranted with a larger cohort to further assess the role of pharmacokinetic modeling in simultaneous PET/MRI imaging.

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Section: Discussionsupporting

confidence: 90%

Assessment of Aggressiveness of Breast Cancer Using Simultaneous 18F-FDG-PET and DCE-MRI

Margolis

Moy

Sigmund

et al. 2016

Clinical Nuclear Medicine

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“…MRI signal intensity is dependent on many factors, including native tissue relaxation rates, contrast agent dose, injection rate, choice of imaging sequence and parameters, machine gain, and scaling factors 22. Therefore, semiquantitative results are not readily applicable from one institution to another, because of different imaging equipment and protocol 23,24. The advantage of semiquantitative analysis is that it is relatively simple in estimating with T1-weighted MRI, whereas quantitative analysis requires conversion of MRI signal intensities to contrast concentration by complex pharmacokinetic modeling 10.…”

Section: Discussionmentioning

confidence: 99%

Correlations of Dynamic Contrast-Enhanced Magnetic Resonance Imaging with Morphologic, Angiogenic, and Molecular Prognostic Factors in Rectal Cancer

et al. 2013

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PurposeTo investigate the correlations between parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and prognostic factors in rectal cancer.Materials and MethodsWe studied 29 patients with rectal cancer who underwent gadolinium contrast-enhanced, T1-weighted DCE-MRI with a three Tesla scanner prior to surgery. Signal intensity on DCE-MRI was independently measured by two observers to examine reproducibility. A time-signal intensity curve was generated, from which four semiquantitative parameters were calculated: steepest slope (SLP), time to peak (Tp), relative enhancement during a rapid rise (Erise), and maximal enhancement (Emax). Morphologic prognostic factors including T stage, N stage, and histologic grade were identified. Tumor angiogenesis was evaluated in terms of microvessel count (MVC) and microvessel area (MVA) by morphometric study. As molecular factors, the mutation status of the K-ras oncogene and microsatellite instability were assessed. DCE-MRI parameters were correlated with each prognostic factor using bivariate correlation analysis. A p-value of <0.05 was considered significant.ResultsErise was significantly correlated with N stage (r=-0.387 and -0.393, respectively, for two independent data), and Tp was significantly correlated with histologic grade (r=0.466 and 0.489, respectively). MVA was significantly correlated with SLP (r=-0.532 and -0.535, respectively) and Erise (r=-0.511 and -0.446, respectively). MVC was significantly correlated with Emax (r=-0.435 and -0.386, respectively). No significant correlations were found between DCE-MRI parameters and T stage, K-ras mutation, or microsatellite instability.ConclusionDCE-MRI may provide useful prognostic information in terms of histologic differentiation and angiogenesis in rectal cancer.

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“…Yao et al (2011) reported moderate and strong relationship between K trans and clinicopathological elements, K trans might be the prognostic indicator of rectal cancer. Gu et al (2011) found a positive correlations between k ep and SUV values in primary rectal adenocarcinomas suggesting an association between angiogenesis and metabolic activity and further reflecting that angiogenic activity in washout phase is better associated with tumor metabolism than the uptake phase. Although these encouraging results, the evaluation after neo-adjuvant therapy remains actually difficult in borderline cases where an overestimation is the most common drawback.…”

Section: Dce-mri In Rectal Cancermentioning

confidence: 70%

Dynamic Contrast Enhanced Magnetic Resonance Imaging in Rectal Cancer

Fusco¹,

Sansone²,

Petrillo³

et al. 2011

Rectal Cancer - A Multidisciplinary Approach to Management

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Dynamic contrast‐enhanced MRI of primary rectal cancer: Quantitative correlation with positron emission tomography/computed tomography

Cited by 17 publications

References 33 publications

Assessment of Aggressiveness of Breast Cancer Using Simultaneous 18F-FDG-PET and DCE-MRI

Assessment of Aggressiveness of Breast Cancer Using Simultaneous 18F-FDG-PET and DCE-MRI

Correlations of Dynamic Contrast-Enhanced Magnetic Resonance Imaging with Morphologic, Angiogenic, and Molecular Prognostic Factors in Rectal Cancer

Dynamic Contrast Enhanced Magnetic Resonance Imaging in Rectal Cancer

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