Dynamic contrast enhanced MRI in prostate cancer

Alonzi, R.; Padhani, Anwar R.; Allen, Clare

doi:10.1016/j.ejrad.2007.06.028

Cited by 187 publications

(124 citation statements)

References 40 publications

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“…Diffusion-weighted (DW) MRI is sensitive to restriction of diffusion of water molecules, and dynamic contrast enhanced (DCE) MRI can analyze tissue microvascular properties. 8 Multiparametric MRI combining DW images (DWI) and DCE has demonstrated its value in distinguishing malignant from benign prostate tissue. 9 However, most of the studies on multiparametric MRI have not specifically focused on low D'Amico risk patients, who are the potential candidates for less aggressive treatment strategies such as active surveillance, brachytherapy or focal ablation.…”

Section: Introductionmentioning

confidence: 99%

Multiparametric MRI is helpful to predict tumor focality, stage, and size in patients diagnosed with unilateral low-risk prostate cancer

Delongchamps

Beuvon

Eiss³

et al. 2011

Prostate Cancer Prostatic Dis

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To study the staging accuracy of multiparametric magnetic resonance imaging (MRI) in patients showing unilateral low-risk cancer on prostate biopsy. A total of 58 consecutive patients with lowrisk cancer (D'Amico classification) and unilateral cancer involvement on prostate biopsies were included prospectively. All patients underwent multiparametric endorectal MRI before radical prostatectomy, including T2-weighted (T2W), diffusion-weighted (DW) and dynamic contrast enhanced (DCE) sequences. Each gland was divided in eight octants. Tumor foci 40.2 cm 3 identified on pathological analysis were matched with MRI findings. Pathological examination showed tumor foci 40.2 cm 3 in 50/58 glands (86%), and bilateral tumor (pathological stageXpT2c) in 20/58 (34%). For tumor detection in the peripheral zone (PZ), T2W þ DWI þ DCE performed significantly better than T2W þ DWI and T2W alone (Po0.001). In the transition zone (TZ), only T2W þ DWI performed better than T2W alone (P ¼ 0.02). With optimal MR combinations, tumor size was correctly estimated in 77% of tumor foci involving more than one octant. Bilateral tumors were detected in 80% (16/20) of cases. In patients with unilateral low-risk prostate cancer on biopsy, multiparametric MRI can help to predict bilateral involvement. Multiparametric MRI may therefore have a prognostic value and help to determine optimal treatment in such patients.

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Section: Introductionmentioning

confidence: 99%

Multiparametric MRI is helpful to predict tumor focality, stage, and size in patients diagnosed with unilateral low-risk prostate cancer

Delongchamps

Beuvon

Eiss³

et al. 2011

Prostate Cancer Prostatic Dis

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show abstract

“…Because the prostate as a whole is highly vascularized, a simple comparison of pre-and post-gadolinium images is usually insufficient to discern prostate cancer. 16,17 A fast and direct method to characterize prostatic vascular pharmacokinetic features is high-temporalresolution contrast-enhanced MR imaging. Dynamic contrast-enhanced MR imaging consists of a series of fast T1-weighted sequences covering the entire prostate before and after rapid injection (2-4 mL/sec) of a bolus of a low molecular-weight gadolinium chelate such as gadoterate meglumine or gadopentetate dimeglumine (concentration, 0.1-0.2 mmol/kg).…”

Section: Discussionmentioning

confidence: 99%

Role of multiparametric MRI in detection of prostatic lesions; of evaluation contrast enhanced MRI, diffusion weighted imaging and MR spectroscopy in malignant and benign prostatic lesions

Yadav

Bhargava

2016

Int J Res Med Sci

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INTRODUCTIONProstate cancer is the most common cancer detected in men in the United States. Approximately 230,000 American men were diagnosed with prostate cancer in 2005.1 Prostate cancer is the second leading cause of cancer death for men.Despite the efficiency of clinical staging, it remains imperfect for precise local cancer staging and intra ABSTRACT Background: Prostate cancer is the most commonly diagnosed cancer in males and one of the leading causes of cancer-related death in men. Pretreatment assessment of prostate cancer is divided into detection, localization, and staging; accurate assessment is a prerequisite for optimal clinical management and therapy selection. The purpose of the study is to determine the diagnostic accuracy of multiparametric MRI for prostatic cancer detection using T2 weighted MR imaging, diffusion weighted imaging (DWI) and contrast enhanced MRI. To determine the use of MR spectroscopy in prostatic lesions. Methods: It is a prospective single institutional study done on 29 patients with prostate lesions and elevated PSA level. Axial, coronal and sagittal images were obtained using T1WI, T2WI and STIR sequences. Advanced sequences like Diffusion weighted images, Spectroscopy and post gadolinium T1WI were taken after the basic MRI images. Results: Study was done in 29 patients, age was ranging between 51years to 90 years, mean age is 70.7 years. On multiparametric MRI findings 45% were detected malignant lesions and 55% patients detected benign lesions. On biopsy correlation 42% of these cases turned out to be malignant and 58% as benign lesions. Detection of malignancy by T2WI imaging alone given sensitivity of 80.1% and specificity of 85.4%.By DWI alone sensitivity was 85.7% and specificity was 89.4%,on MRS sensitivity is 90.6% and specificity was 91.1%. Combined (MRI+DWI+MRS) gave sensitivity of 92.3% and specificity of 94.4% for detection of malignant prostatic lesion. Positive predictive value is 90% and negative predictive value was 88%. Conclusions: The best characterization of prostatic cancer in individual patients will most likely result from a multiparametric exam. Recent advances include additional functional and physiologic MR imaging techniques (diffusion weighted imaging, MR spectroscopy, and perfusion imaging), which allow extension of the obtainable information beyond anatomic assessment. Multiparametric MR imaging provides the highest accuracy in diagnosis and staging of prostate cancer.

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“…Rubin et al, however, found that MVD did not correlate consistently with outcome after radical prostatectomy (42). Alonzi et al have presented a comprehensive discussion of contrast kinetics in the prostate that includes a discussion of DSC-MRI (43).…”

Section: T2* Functional Mri Methodsmentioning

confidence: 99%

MRI of the prostate: Clinical relevance and emerging applications

Mazaheri

Shukla–Dave

Muellner

et al. 2011

Magnetic Resonance Imaging

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MRI of the prostate can aid in many aspects of prostate cancer management, from initial detection to treatment planning and follow-up. This review describes the current strengths and limitations of conventional anatomic and molecular MR imaging techniques (including MR spectroscopic imaging and dynamic contrast-enhanced imaging) for aiding prostate cancer management. It also describes promising emerging approaches for acquiring, analyzing, and applying MR imaging data, and the major research and educational efforts that will be required to realize the potential of prostate MR imaging in routine clinical practice.

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Dynamic contrast enhanced MRI in prostate cancer

Cited by 187 publications

References 40 publications

Multiparametric MRI is helpful to predict tumor focality, stage, and size in patients diagnosed with unilateral low-risk prostate cancer

Multiparametric MRI is helpful to predict tumor focality, stage, and size in patients diagnosed with unilateral low-risk prostate cancer

Role of multiparametric MRI in detection of prostatic lesions; of evaluation contrast enhanced MRI, diffusion weighted imaging and MR spectroscopy in malignant and benign prostatic lesions

MRI of the prostate: Clinical relevance and emerging applications

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