Dynamic contrast-enhanced magnetic resonance imaging biomarkers in head and neck cancer: Potential to guide treatment? A systematic review

Bernstein, Jonathan M; Homer, Jarrod J; West, Catharine M L

doi:10.1016/j.oraloncology.2014.07.011

Cited by 81 publications

(85 citation statements)

References 59 publications

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“…These studies have been summarized in two systematic reviews published in recent years. 58,59 The most commonly reported pre-treatment DCE parameters with predictive or prognostic value are K trans , followed by V e and V p . Two earlier clinical studies have shown low pre-treatment nodal tumour K trans to be correlated with poor locoregional control and disease-free survival.…”

Section: Functional Mri Sequencesmentioning

confidence: 99%

The emerging potential of magnetic resonance imaging in personalizing radiotherapy for head and neck cancer: an oncologist's perspective

Wong

Panek

Bhide

et al. 2017

The British Journal of Radiology

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Head and neck cancer (HNC) is a challenging tumour site for radiotherapy delivery owing to its complex anatomy and proximity to organs at risk (OARs) such as the spinal cord and optic apparatus. Despite significant advances in radiotherapy planning techniques, radiation-induced morbidities remain substantial. Further improvement would require high-quality imaging and tailored radiotherapy based on intratreatment response. For these reasons, the use of MRI in radiotherapy planning for HNC is rapidly gaining popularity. MRI provides superior soft-tissue contrast in comparison with CT, allowing better definition of the tumour and OARs. The lack of additional radiation exposure is another attractive feature for intratreatment monitoring. In addition, advanced MRI techniques such as diffusion-weighted, dynamic contrast-enhanced and intrinsic susceptibility-weighted MRI techniques are capable of characterizing tumour biology further by providing quantitative functional parameters such as tissue cellularity, vascular permeability/perfusion and hypoxia. These functional parameters are known to have radiobiological relevance, which potentially could guide treatment adaptation based on their changes prior to or during radiotherapy. In this article, we first present an overview of the applications of anatomical MRI sequences in head and neck radiotherapy, followed by the potentials and limitations of functional MRI sequences in personalizing therapy. INTRODUCTIONRadical radiotherapy (RT) is integral to the management of head and neck cancer (HNC) in both the primary and adjuvant settings. Advances in computer-assisted radiological techniques over the past two decades have in turn revolutionized radiotherapy planning. Development of advanced radiotherapy planning techniques such as intensity-modulated radiotherapy (IMRT) and volumetricmodulated arc therapy have allowed for better dose conformation to the tumour target and sparing of surrounding normal tissues. HNC was one of the first tumour sites where IMRT was widely implemented owing to a significant reduction in radiation-induced xerostomia in comparison with three-dimensional conformal planning.

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Section: Functional Mri Sequencesmentioning

confidence: 99%

The emerging potential of magnetic resonance imaging in personalizing radiotherapy for head and neck cancer: an oncologist's perspective

Wong

Panek

Bhide

et al. 2017

The British Journal of Radiology

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“…Dynamic contrast-enhanced (DCE) MRI is a complex technique for the analysis of microvascular parameters of tissue perfusion [31,32]. It requires the placement of a region of interest within the tumor to calculate time-intensity curves (TIC) and semiquantitative parameters such as the area under the curve (AUC, relative quantity of contrast over time), peak enhancement (maximum concentration of contrast), wash-in (velocity of enhancement), wash-out (velocity of enhancement loss), maximum signal enhancement ratio (SER), and time to maximum enhancement (TME).…”

Section: Vessels and Perfusion: 3d-tof Twist/tricks Angiography Dcementioning

confidence: 99%

“…The output may vary between and within institutions, because of differences in T1 analysis, methods to measure arterial input function (AIF), choice of ROI, scanner model, pharmacokinetic model and time point chosen during treatment [33]. However, K trans emerged as a marker for tumor hypoxia indicating poorer survival or poorer treatment response and has the potential to be a useful biomarker to guide treatment in head & neck squamous cell cancer [32,34,35]. It may also have the potential to identify early locoregional recurrence and differentiate metastatic lymph nodes from normal nodes [36].…”

Section: Vessels and Perfusion: 3d-tof Twist/tricks Angiography Dcementioning

confidence: 99%

“…high-resolution dark signal of cranial nerves and very high signal of liquor in SSFP [20] labyrinthitis lower signal intensity than liquor on SSFP [22] menière's disease endolymphatic hydrops as ratio of high post-gadolinium 3D-FLAIR signal intensity in the perilymphatic space and the high signal in MRI cisternographic sequences in both endolymph and perilymph: vestibule (mild: 34 -50 %, significant: > 50) cochlea (mild: extrusion of the scala media, significant: scala media larger than scala vestibuli) [25] 3D-TOF, TWIST/ TRICKS angiography, DCE vascular contact syndromes point, longitudinal and loop compression as well as indentation of cranial nerves on 3D-TOF [26] infantile hemangioma arterial enhancement on TWIST with gadofosveset trisodium [30] venous malformation venous enhancement on TWIST with gadofosveset trisodium [30] lymphatic malformation no enhancement on TWIST with gadofosveset trisodium [30] arteriovenous malformation arterial and venous enhancement on TWIST with gadofosveset trisodium [30] hypoxia low K trans [32] bone do not cause severe artifacts (as typically seen in computed tomography CT), which makes MRI a superior image modality for delineating tumors in the oropharynx and oral cavity [5]. The ability to discriminate fluid and mucus from soft tissue is extremely helpful in the imaging of sinonasal tumors.…”

Section: Introductionmentioning

confidence: 99%

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MRI Sequences in Head & Neck Radiology – State of the Art

Widmann¹,

Henninger²,

Kremser³

et al. 2017

Fortschr Röntgenstr

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ZUSAMMENFASSUNGHintergrund Magnetic resonance imaging (MRI) ist ein essentielles bildgebendes Verfahren für die Beurteilung von Kopf-Hals Erkrankungen. Die diagnostische Aussagekraft der MRI ist jedoch stark von der entsprechenden Auswahl und Interpretation der Protokolle und Sequenzen abhängig. Das Ziel dieses Beitrags ist es, State-of-the-art-Sequenzen für die klinische Routine der Kopf-Hals-MRI zusammenzufassen und die Evidenz zu beschreiben, für welche medizinische Fragestellungen diese Sequenzen nützlich sind.Methode Literaturübersicht von State-of-the-art-Sequences in der Kopf-Hals-MRI.

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“…Administration of external markers of hypoxia also represents an invasive procedure, requiring subsequent biopsy and the acquired information is also very limited in space and time. Less invasive techniques, based on positron emission tomography or nuclear magnetic resonance imaging have signifi cantly lower specifi city and sensitivity (7,8). Thus neither oxygen electrode measurement nor external hypoxia markers can be routinely applied in everyday clinical practice.…”

Section: Introductionmentioning

confidence: 99%

High serum carbonic anhydrase IX predicts shorter survival in head and neck cancer

Rosenberg¹,

Pastorekova²,

Zaťovičová³

et al. 2016

BLL

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OBJECTIVES: The objective of the study was to investigate prognostic and predictive value of pretreatment soluble carbonic anhydrase IX (CA IX) blood serum concentration in patients with locally advanced head and neck cancer. BACKGROUND: Increased expression of CA IX in tumor tissues has been associated with treatment resistance and worth prognosis. Soluble form of CA IX, released from tumor cells, is detectable in blood serum and could be a convenient predictive factor of treatment effectiveness that would enable treatment individualization. METHODS: The prospective study evaluated 48 patients with locally advanced squamous cell carcinomas of head and neck, treated by radiotherapy or chemo-radiotherapy. Pretreatment soluble CA IX serum concentrations were examined using enzyme-linked immunosorbent assay. RESULTS: Soluble CA IX serum concentration failed to predict radiotherapy effectiveness in the studied patient population (p = 0.26). However, high CA IX serum concentrations have been associated with shorter overall survival (p = 0.035) CONCLUSION: High pretreatment CA IX serum concentration is a negative prognostic factor in locally advanced head and neck cancer patients (Tab. 1, Fig. 2

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Dynamic contrast-enhanced magnetic resonance imaging biomarkers in head and neck cancer: Potential to guide treatment? A systematic review

Cited by 81 publications

References 59 publications

The emerging potential of magnetic resonance imaging in personalizing radiotherapy for head and neck cancer: an oncologist's perspective

The emerging potential of magnetic resonance imaging in personalizing radiotherapy for head and neck cancer: an oncologist's perspective

MRI Sequences in Head & Neck Radiology – State of the Art

High serum carbonic anhydrase IX predicts shorter survival in head and neck cancer

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