Dynamic Contrast-Enhanced Computed Tomography Imaging Biomarkers Correlated With Immunohistochemistry for Monitoring the Effects of Sorafenib on Experimental Prostate Carcinomas

Cyran, Clemens C.; Einem, Jobst C. von; Paprottka, Philipp M.; Schwarz, Bettina; Ingrisch, Michael; Dietrich, Olaf; Hinkel, Rabea; Bruns, Christiane; Clevert, D.‐A.; Eschbach, Ralf; Reiser, Maximilian; Wintersperger, Bernd J.; Nikolaou, Konstantin

doi:10.1097/rli.0b013e3182300fe4

Cited by 37 publications

(25 citation statements)

References 45 publications

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“…Emerging functional and molecular imaging techniques using MR imaging, CT, US, positron emission tomography (PET), and optical-based technologies are being developed and have shown promising results for monitoring cancer more accurately than traditional morphologic imaging (11)(12)(13)(14)(15)(16)(17). Among these, CT is currently the most commonly used first-line imaging modality for staging and monitoring of diseases in oncology because of its wide availability and the availability of standardized CT protocols which yield reproducible imaging results.…”

Section: Accreditation and Designation Statementmentioning

confidence: 99%

CT Perfusion of the Liver: Principles and Applications in Oncology

Kim¹,

Kamaya²,

Willmann³

2014

Radiology

171

135

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With the introduction of molecularly targeted chemotherapeutics, there is an increasing need for defining new response criteria for therapeutic success because use of morphologic imaging alone may not fully assess tumor response. Computed tomographic (CT) perfusion imaging of the liver provides functional information about the microcirculation of normal parenchyma and focal liver lesions and is a promising technique for assessing the efficacy of various anticancer treatments. CT perfusion also shows promising results for diagnosing primary or metastatic tumors, for predicting early response to anticancer treatments, and for monitoring tumor recurrence after therapy. Many of the limitations of early CT perfusion studies performed in the liver, such as limited coverage, motion artifacts, and high radiation dose of CT, are being addressed by recent technical advances. These include a wide area detector with or without volumetric spiral or shuttle modes, motion correction algorithms, and new CT reconstruction technologies such as iterative algorithms. Although several issues related to perfusion imagingsuch as paucity of large multicenter trials, limited accessibility of perfusion software, and lack of standardization in methods-remain unsolved, CT perfusion has now reached technical maturity, allowing for its use in assessing tumor vascularity in larger-scale prospective clinical trials. In this review, basic principles, current acquisition protocols, and pharmacokinetic models used for CT perfusion imaging of the liver are described. Various oncologic applications of CT perfusion of the liver are discussed and current challenges, as well as possible solutions, for CT perfusion are presented.q RSNA, 2014

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Section: Accreditation and Designation Statementmentioning

confidence: 99%

CT Perfusion of the Liver: Principles and Applications in Oncology

Kim¹,

Kamaya²,

Willmann³

2014

Radiology

171

135

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“…9,10 Hence, the evolving therapeutic field of vascular-modulating drugs requires new noninvasive methods for assessing tumor vascularity in vivo. [11][12][13][14][15] In 1967, Milne 16 showed that lung tumors may have a dual blood supply by the pulmonary and the aortic system, with a trend toward histological type-specific circulatory pattern. The advent of CT perfusion (CTP) within the last decade allowed for a direct, noninvasive quantification of the vascular function.…”

Section: Results: According To Biopsy 37 Patients Had Nsclc (22 Adenmentioning

confidence: 99%

Assessment of Bronchial and Pulmonary Blood Supply in Non-Small Cell Lung Cancer Subtypes Using Computed Tomography Perfusion

Nguyen-Kim¹,

Frauenfelder²,

Strobel³

et al. 2015

Investigative Radiology

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OBJECTIVES: The aim of this study was to investigate the dual blood supply of non-small cell lung cancer (NSCLC) and its association with tumor subtype, size, and stage, using computed tomography perfusion (CTP). MATERIALS AND METHODS: A total of 54 patients (median age, 65 years; range, 42-79 years; 15 women, 39 men) with suspected lung cancer underwent a CTP scan of the lung tumor. Pulmonary and bronchial vasculature regions of interest were used to calculate independently CTP parameters (blood flow [BF], blood volume [BV], and mean transit time [MTT]) of the tumor tissue. The mean and maximum pulmonary and bronchial perfusion indexes (PImean and PImax) were calculated. The tumoral volume and the largest tumoral diameter were assessed. Differences in CTP parameters and indexes among NSCLC subtypes, tumor stages and tumor dimensions were analyzed using non-parametric tests. RESULTS: According to biopsy, 37 patients had NSCLC (22 adenocarcinomas [ACs], 8 squamous cell carcinomas [SCCs], 7 large-cell carcinomas [LCC]). The mean bronchial BF/pulmonary BF, bronchial BV/pulmonary BV, and bronchial MTT/pulmonary MTT was 41.2 ± 30.0/36.9 ± 24.2 mL/100 mL/min, 11.4 ± 9.7/10.4 ± 9.4 mL/100 mL, and 11.4 ± 4.3/14.9 ± 4.4 seconds, respectively. In general, higher bronchial BF than pulmonary BF was observed in NSCLC (P = 0.014). Using a tumoral volume cutoff of 3.5 cm, a significant difference in pulmonary PImax was found (P = 0.028). There was a significantly higher mean pulmonary BF in LCCs and SCCs compared with ACs (P = 0.018 and P = 0.044, respectively), whereas the mean bronchial BF was only significantly higher in LCCs compared with ACs (P = 0.024). Correspondingly, the PImax was significantly higher in LCCs and SCCs than in ACs (P = 0.001 for both). Differences between bronchial and pulmonary PImean and PImax among T stages and Union Internationale Contre le Cancer stages were not statistically significant (P values ranging from 0.691 to 0.753). CONCLUSIONS: The known dual blood supply of NSCLC, which depends on tumor size and histological subtype, is reflected in CTP parameters, with parameters depending both on tumor size and histological subtype. This has to be accounted for when analyzing NSCLC with CTP.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/3.0.

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“…Besides, CTP imaging is performed much faster than MRI, its application is more convenient for the patient, and can easily be combined with an abdominal staging CT as part of the same Experimental work has also shown the usefulness of CTP for response assessment to radiotherapy and anti-angiogenic drugs. [14,15] One inherent drawback of CTP is the additional radiation burden delivered to the patient, requiring a well-considered weighing of potential benefits of cancer characterization. It should however be noted that the prostate-though being the most sensitive organ within the field -in any way will undergo organdestructive treatment, be it by radiotherapy or by prostatectomy.…”

Section: Discussionmentioning

confidence: 99%

Assessment of prostate cancer with integrated CT-perfusion using a sector-wise approach

Ferrari¹,

Huellner²,

Pauli³

et al. 2017

Turkish Journal of Urology

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Objective: The role of computed tomography perfusion (CTP) in characterizing primary prostate cancer (PCa) is not definitely known. The aim of the present study was to investigate the relationship between CTP parameters and histopathological features of PCa tissue, using a sector-wise approach. Material and methods:Fifty-one patients with biopsy-proven PCa underwent prospectively a CTP scan prior to radical prostatectomy. Blood flow (BF), mean blood volume (BV) and mean transit time (MTT) were calculated, with the prostate being divided into eight sectors. Corresponding sector-wise histopathological analysis of whole-mount prostatectomy specimens was performed to determine tumoral area (mm Conclusion: BF correlates weakly with size and vascularity of PCa. There is a need for further studies to elucidate the association between CTP parameters and other histopathological parameters.

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Dynamic Contrast-Enhanced Computed Tomography Imaging Biomarkers Correlated With Immunohistochemistry for Monitoring the Effects of Sorafenib on Experimental Prostate Carcinomas

Cited by 37 publications

References 45 publications

CT Perfusion of the Liver: Principles and Applications in Oncology

CT Perfusion of the Liver: Principles and Applications in Oncology

Assessment of Bronchial and Pulmonary Blood Supply in Non-Small Cell Lung Cancer Subtypes Using Computed Tomography Perfusion

Assessment of prostate cancer with integrated CT-perfusion using a sector-wise approach

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