Dynamic Compression Effects on Intervertebral Disc Mechanics and Biology

Korecki, Casey L.; MacLean, Jeffrey J.; Iatridis, James C.

doi:10.1097/brs.0b013e318175cae7

Cited by 103 publications

(90 citation statements)

References 23 publications

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“…In a bovine disc organ culture model, with the endplates removed, it has been demonstrated that diurnal loading was better to maintain GAG content than static loading but little beneficial effect was found with dynamic loading in a human physiological range (0.2-1 MPa disc pressure, 1 Hz) [57,58]. It is likely that the removal of endplates from the IVD affected the cell viability and the biosynthetic activity of the disc cells [61].…”

Section: In Vitro Organ Culturementioning

confidence: 99%

“…Static loading, static diurnal loading or a continuous dynamic loading results in different responses of the IVD [19,57,58,72,75,123]. Studies comparing the different axial loadings (static, diurnal or dynamic compression) are summarised in Table 1.…”

Section: Static Diurnal and Dynamic Compressionmentioning

confidence: 99%

“…The effect of the magnitude of dynamic compression was compared [58] in an in vitro culture system using bovine discs cultured without endplates. It was suggested that dynamic compression of 0.2-1 MPa, for 1 h/day for 5 days, increases the disc's metabolic rate and enhances anabolic remodelling, whereas compression of 0.2-2.5 MPa induces catabolic response in the disc.…”

Section: Magnitude Response: Axial Compressionmentioning

confidence: 99%

“…MSC differentiation can be directed by different factors, such as growth factors, or more importantly by mechanical factors, including shear, tension, compressive strain and hydrostatic pressure, all depending on the local environment such as matrix stiffness and structural arrangement, and the resulting cell shape and morphology differences, pH, oxygen and nutrient supply [52,93]. [45,58,70,72,122,123] MSCs in the IVD environment…”

Section: Ivd Tissue Engineeringmentioning

confidence: 99%

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The effects of dynamic loading on the intervertebral disc

2011

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Loading is important to maintain the balance of matrix turnover in the intervertebral disc (IVD). Daily cyclic diurnal assists in the transport of large soluble factors across the IVD and its surrounding circulation and applies direct and indirect stimulus to disc cells. Acute mechanical injury and accumulated overloading, however, could induce disc degeneration. Recently, there is more information available on how cyclic loading, especially axial compression and hydrostatic pressure, affects IVD cell biology. This review summarises recent studies on the response of the IVD and stem cells to applied cyclic compression and hydrostatic pressure. These studies investigate the possible role of loading in the initiation and progression of disc degeneration as well as quantifying a physiological loading condition for the study of disc degeneration biological therapy. Subsequently, a possible physiological/beneficial loading range is proposed. This physiological/beneficial loading could provide insight into how to design loading regimes in specific system for the testing of various biological therapies such as cell therapy, chemical therapy or tissue engineering constructs to achieve a better final outcome. In addition, the parameter space of 'physiological' loading may also be an important factor for the differentiation of stem cells towards most ideally 'discogenic' cells for tissue engineering purpose.

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Section: In Vitro Organ Culturementioning

confidence: 99%

Section: Static Diurnal and Dynamic Compressionmentioning

confidence: 99%

Section: Magnitude Response: Axial Compressionmentioning

confidence: 99%

Section: Ivd Tissue Engineeringmentioning

confidence: 99%

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The effects of dynamic loading on the intervertebral disc

2011

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“…The present work measures proteoglycan synthesis under static loading conditions, which raises the question of whether a similar response would be seen under more physiological dynamic loading. As current data suggests that dynamic loading stimulates proteoglycan synthesis (Korecki et al, 2008), there is no reason to believe that dynamic loading would adversely affect the ability of Link-N to stimulate proteoglycan synthesis. Indeed, it may enhance the effect.…”

Section: Discussionmentioning

confidence: 96%

Best Paper NASS 2013: Link-N can stimulate proteoglycan synthesis in the degenerated human intervertebral discs

Gawri¹,

Antoniou²,

Ouellet³

et al. 2013

eCM

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Intervertebral disc (IVD) degeneration is the most common cause of back pain. Presently there is no medical treatment, leaving surgery as the only offered option. Here we evaluate the potential of Link-N to promote extracellular matrix regeneration in human IVDs. Human disc cells cultured in alginate and intact human discs were exposed to a combination of Link-N and 35 SO 4 in the presence or absence of interleukin (IL)-1, and the effect on proteoglycan synthesis was evaluated. In addition, message levels of aggrecan, matrix metalloproteinase (MMP)-3, MMP-13, a Disintegrin And Metalloproteinase with Thrombospondin Motifs (ADAMTS)-4 and ADAMTS-5 were evaluated in alginate cultures. Human disc cells responded in a dose dependent manner with maximal proteoglycan synthesis at 1 µg/mL Link-N. Link-N treatment also induced proteoglycan synthesis in intact human discs, and a prolonged effect was found up to one week after Link-N treatment. Message levels of proteinases were decreased by Link-N in the presence of IL-1. Thus, Link-N can promote proteoglycan synthesis and deplete proteinase expression in adult human discs. Link-N could therefore be a promising candidate for biologically-induced disc repair, and could provide an alternative to surgical intervention for early stage disc degeneration.

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