Dynamic changes of estimated glomerular filtration rate are conversely related to triglyceride in non-overweight patients

Liu, Siqi; Zhang, Xiujun; Xue, Yuan; Huang, Rui; Wang, Jian; Wu, Chao; He, Yi-Shan; Pan, Ya-Ru; Liu, Longgen

doi:10.12998/wjcc.v10.i31.11371

Cited by 1 publication

(1 citation statement)

References 25 publications

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“…It has been reported that TG has a negative relationship with eGFR in children and adolescents [ 11 ]. Our previous study also showed that TG negatively correlated with eGFR in patients without overweight [ 19 ]. Decreased eGFR may result from delayed hepatic clearance of lipoproteins during dyslipidemia [ 20 ].…”

Section: Discussionmentioning

confidence: 91%

Estimated glomerular filtration rate partially recovered in patients without Hypertriglyceridemia during Tenofovir disoproxil fumarate treatment

Pan

Liu

et al. 2023

Annals of Medicine

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Background Decrease in estimated glomerular filtration rate (eGFR) during Tenofovir disoproxil fumarate (TDF) treatment remains a concern, and few patients experience partial recovery of eGFR. This study aimed to investigate the risk factors for eGFR recovery in patients with and without hypertriglyceridemia. Methods A total of 203 patients with chronic HBV infection were prospectively recruited and followed up for three years. Data were collected at baseline, first, second, and third years during TDF treatment. Results Most patients achieved normal ALT (80.0% vs. 82.5%) and undetectable HBV DNA (95.0% vs. 95.6%) in both groups ( p > 0.05). For patients with hypertriglyceridemia, eGFR and cholesterol did not change significantly during the 3-year follow-up, while triglyceride (TG) decreased significantly in the first year and persisted at a lower level in the subsequent two years. For patients without hypertriglyceridemia, eGFR declined significantly in the first year of treatment, then gradually recovered during the subsequent two years, and eGFR was negatively correlated with TG at the four time points. Fifteen (15/183, 8.2%) patients without hypertriglyceridemia experienced eGFR partial recovery in the third year. Univariate and multivariate analyses showed that baseline eGFR <90 mL/(min·1.73 m 2 ) ( p < 0.01; 95% CI: 0.019–0.284) and age ( p < 0.01; 95% CI: 0.817–0.960) were independent risk factors for eGFR recovery. Conclusion eGFR partially recovered in patients without hypertriglyceridemia during TDF treatment, and TG regulation might be a useful strategy to hinder renal function decline, although larger, confirmatory studies are necessary to validate our findings. Key messages For patients with normal triglyceride, eGFR declined significantly at the first year of TDF treatment, then gradually recovered during the subsequent two years, and eGFR was negatively correlated with TG. Baseline eGFR <90 mL/(min·1.73 m 2 ) and age were independent risk factors for eGFR recovery.

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Section: Discussionmentioning

confidence: 91%