Dynamic changes in sleep pattern during post-partum in normal pregnancy in rat model

Sivadas, Neelima; Radhakrishnan, Arathi; Aswathy, B.S.; Kumar, Velayudhan Mohan; Gulia, Kamalesh K.

doi:10.1016/j.bbr.2016.11.040

Cited by 34 publications

(33 citation statements)

References 56 publications

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“…Sleep loss during pregnancy is an emerging concern that affects the development of the growing fetus and babies. Even during normal pregnancy, in human and animal species the quality of sleep becomes poor and fragmented during the last trimester (Driver and Shapiro, 1992;Nishina et al, 1996;Sivadas et al, 2017;Wilson et al, 2011). Any further loss of sleep during pregnancy can compromise normal development in the growing offspring (Chang et al, 2010;Gulia and Kumar, 2018;Gulia et al, 2014Gulia et al, , 2015Micheli et al, 2011;Radhakrishnan et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

The effects of rapid eye movement sleep deprivation during late pregnancy on newborns' sleep

Aswathy

Kumar

Gulia

2017

Journal of Sleep Research

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Sleep deprivation during pregnancy is an emerging concern, as it can adversely affect the development of the offspring brain. This study was conducted to evaluate the effects of deprivation of rapid eye movement (REM) sleep during the third term of pregnancy on the sleep-wake profiles of neonates in the Wistar rat model. Sleep-wake patterns were assessed through electrophysiological measures and behavioural observations during postnatal days 1-21 on pups born to REM sleep-deprived dams and control rats. Pups of REM sleep-deprived dams had active sleep that was not only markedly higher in percentage during all the days studied, but also had reduced latency during later postnatal days 15-21. Quiet sleep and wake periods were lower. These factors, along with less frequent but longer sleep-wake cycles, indicated maturational delay in the sleep-wake neural networks. The disruption of time-bound growth of sleep-wake neural networks was substantiated further by the decreased slope of survival plots in the sleep bouts. Examination of altered sleep-wake patterns during early development may provide crucial information concerning deranged neural development in the offspring. This is the first report, to our knowledge, to show that maternal sleep deprivation during pregnancy can delay and impair the development of sleep-wake profile in the offspring.

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Section: Introductionmentioning

confidence: 99%

The effects of rapid eye movement sleep deprivation during late pregnancy on newborns' sleep

Aswathy

Kumar

Gulia

2017

Journal of Sleep Research

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“…Therefore, non‐invasive neonatal sleep evaluation can provide useful information about the brain development especially in moderate to high risk neonates. Even in normal pregnancy, the sleep disturbances during the last trimester are common due to several compelling reasons (Driver and Shapiro, 1992; Wilson et al, 2011; Mindell et al, 2015; Reichner, 2015; Sivadas et al, 2017). However, any further loss of sleep is likely to manifest in altered ontogenic development of neural network of the foetus (Gulia et al, 2014, 2015; Radhakrishnan et al, 2015; Aswathy et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Prior to mating, 14 adult female rats were implanted with electrodes for electrophysiological evaluation of sleep onset during the sleep restriction procedure. Under Ketamine (Indian Immunologicals Limited) and Xylazine (Neon Laboratories Limited) anaesthesia, the EEG and EMG electrodes were implanted in the parietal cortical region and in the nuchal muscle respectively, and were soldered to an IC socket that was fixed over the head with dental cement, as described previously (Gulia et al, 2008; Sivadas et al, 2017). After the post‐operative recovery period of 10 days, these females were kept with males of similar age and strain for mating.…”

Section: Methodsmentioning

confidence: 99%

Immature sleep pattern in newborn rats when dams encountered sleep restriction during pregnancy

Aswathy

Kumar

Gulia

2018

Intl J of Devlp Neuroscience

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There is a growing realization that proper sleep during pregnancy is essential for the health of the mother and the offspring. However, there are no reports on the effects of maternal sleep restriction on the sleep-wake profiles of newborns. So, this study was conducted to evaluate the effects of sleep restriction during the third term of pregnancy on the sleep-wake profiles of neonates born to them. The female pregnant Wistar rats were sleep restricted for 5 h/day on gestational days 15-20 by gentle handling. Sleep-wake profiles of the pups born to them and to the control rats were recorded on postnatal days 1-21. Pups of sleep restricted dams had higher active sleep (AS) and lower quiet sleep (QS) as well as wakefulness. Higher ratio of AS to QS, longer duration of sleep cycles, lesser bout frequency and reduced EEG delta power were also observed in these pups, all of which indicated brain immaturity. All these signs of delayed maturation, usually found in premature babies, were observed in the pups of sleep restricted mothers, who had longer gestation period. This report not only shows the importance of sleep during pregnancy, but it also suggests that neonatal sleep monitoring can be used as a tool for early assessment of retarded brain development.

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“…3E). (Sivadas et al 2017). Given that in humans the newborns are among the most neurologically immature at birth, the sleep loss of the mother is thought to be adaptive in allowing improved monitoring and care for the young (McKenna et al 1993).…”

Section: Discussionmentioning

confidence: 99%

“…For example, Killer-whale and bottle-nose dolphin mothers show attenuated circadian activity rhythms and little sleep during the first month post-partum, when they need to help their calves surface to breath (Lyamin et al 2005). Similarly, mother rats show decreased non-REM sleep duration on the days following parturition when their newborn pups are completely dependent on their nursing and care (Sivadas et al 2017). Interestingly, the mother's sleep is deeper when she eventually falls asleep, possibly compensating for the reduction in sleep duration.…”

Section: Introductionmentioning

confidence: 99%

Signals from the brood modulate the sleep of brood tending bumblebee workers

Nagari

Jönsson

et al. 2018

Preprint

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Sleep is ubiquitous in vertebrates and invertebrates, and its chronic lost is typically associated with reduced performance, health, or survival. Nevertheless, some animals can give up sleep in order to increase survival or mating opportunities. We studied the interplay between sleep and brood care in the social bumblebee Bombus terrestris. We first used video recording and detailed behavioral analyses to confirm that the bumblebee shows the essential behavioral characteristics of sleep. Based on these analyses we next used immobility bouts of >5' as proxy for sleep in automatic activity monitoring records, and found that sleep is severely reduced in the presence of larvae that require feeding or pupae that are not fed. Reduced sleep was correlated with wax pot building, which is a behavior typical to nest founding mother queens. Sleep was also reduced in the presence of empty cocoons, but this effect was transient and reduced with time. This observation that is consistent with the presence of a sleep modulating pheromonal signal. These results provide the first evidence for brood modulation of sleep in an insect, and are consistent with the hypothesis that plasticity in sleep can evolve as a mechanism to improve care for dependent juveniles.

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Dynamic changes in sleep pattern during post-partum in normal pregnancy in rat model

Cited by 34 publications

References 56 publications

The effects of rapid eye movement sleep deprivation during late pregnancy on newborns' sleep

The effects of rapid eye movement sleep deprivation during late pregnancy on newborns' sleep

Immature sleep pattern in newborn rats when dams encountered sleep restriction during pregnancy

Signals from the brood modulate the sleep of brood tending bumblebee workers

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