Dynamic Change of Fecal Calprotectin in Very Low Birth Weight Infants during the First Month of Life

Yang, Qing; Smith, P. Brian; Goldberg, Ronald N.; Cotten, C. Michael

doi:10.1159/000151645

Cited by 71 publications

(80 citation statements)

References 37 publications

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“…In the study of Yang et al mean GA was found 26.6±2.1 weeks and mean birth weight was 982.1±289.4 gm. 12 Aydemir et al found in their study that the mean GA was 29 weeks, mean birth weight of 950 gm and a mean age of 14 days at diagnosis. 13 In our study, from a total of 500 neonates, 21 preterm showed signs of feeding intolerance.…”

Section: Discussionmentioning

confidence: 93%

Feeding Intolerance in Preterm Neonates in Neonatal Intensive Care Unit, Padma General hospital, Dhaka

Islam

Begum²,

Yasmeen³

et al. 2017

Northern Int. Med. Coll. J.

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Background : Premature infants frequently suffer from feeding intolerance and is highly associated to morbidity and mortality. It is a great challenge which have to face all the neonatologist. Feeding intolerance can be defined by difficulty in ingestion or digestion of the milk that causes a disruption in the enteral feeding plan due to the manifestation of some clinical symptoms. These symptoms include gastric residuals, emesis, abdominal distention, visible bowel loops, and change in the character of stool etc.

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Section: Discussionmentioning

confidence: 93%

Feeding Intolerance in Preterm Neonates in Neonatal Intensive Care Unit, Padma General hospital, Dhaka

Islam

Begum²,

Yasmeen³

et al. 2017

Northern Int. Med. Coll. J.

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“…Yang et al reported that f-CP levels were not related to gestational age or feeding regimens in VLBW infants. 21 In contrast, Zoppelli et al examined 1,899 fecal samples from 206 VLBW infants and found that f-CP levels were dependent on gestational and postnatal age with particularly low levels in extremely premature infants. 13 Zoppelli et al measured over 28 days and had 66 cases of NEC or other gastrointestinal disease.…”

Section: Discussionmentioning

confidence: 98%

Relationships of Feeding and Mother's Own Milk with Fecal Calprotectin Levels in Preterm Infants

Groër

Ashmeade

Louis‐Jacques

et al. 2016

Breastfeeding Medicine

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Objective: To describe longitudinal effects of feeding volume and type of milk on fecal calprotectin (f-CP) in very low-birth weight (VLBW) infants. Study Design: Prospective data were collected across Neonatal Intensive Care Unit (NICU) admission for 6 weeks or until discharge in 75 VLBW neonates. The mean gestational age on entry into the study was 29 weeks. Results: Seventy-four (99%) mothers provided expressed milk in varying amounts. Twenty-three mothers (31%) provided exclusive mother's own milk (MOM) throughout. Preterm infant formula (PIF) and pasteurized donor milk were added to feedings of remaining infants. Pooled MOM was analyzed weekly for levels of a panel of cytokines, chemokines, and growth factors, and secretory Immunoglobulin A (sIgA) so that the exact amount of exposure to the gut of these milk bioactives could be estimated. f-CP levels ranged from 160 to 350 lg/g stool. Total feeding volume was positively associated with f-CP, controlling for infant weight, and f-CP levels rose across time. Exclusive MOM feedings for the entire measurement period were associated with rising levels of f-CP, but mixed feedings (MOM with added PIF or pasteurized donor milk (PDM) did not show this increase over time. Conclusion:The presence of f-CP may represent a response to milk volumes and MOM, which represents normal development rather than always implicating pathological inflammation in the VLBW infant.

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“…Not surprisingly, several studies have been performed aiming to determine cut-off values for fCP in premature infants evaluating its suitability for detection of NEC [11,12,13,14]. Unfortunately, this undertaking seemed futile due to high intra- and interindividual variations and a large number of factors influencing fCP expression, particularly during the first week of life.…”

Section: Introductionmentioning

confidence: 99%

Fecal Calprotectin Concentrations in Premature Infants Have a Lower Limit and Show Postnatal and Gestational Age Dependence

Zoppelli¹,

Güttel²,

Bittrich³

et al. 2012

Neonatology

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Background: There is a need for reliable diagnostic biomarkers in necrotizing enterocolitis (NEC). Whereas fecal calprotectin (fCP) has been reported to have insufficient sensitivity and specificity, no previous study has stratified for gestational and postnatal age. Objective: We aimed to provide developmental specific fCP data in premature infants and to analyze its value in detecting intestinal distress and episodes of NEC. Methods: Between April 2008 and December 2009, 1,899 fecal samples were obtained from 206 very low birth weight infants. Results: Mean gestational age (GA) was 28.5 weeks and birth weight 1,057 g. 19 (9.2%) patients developed NEC stage II+, of whom 5 had fulminant NEC with unusually low fCP concentrations in meconium and afterwards. fCP levels showed significant gestational and postnatal age dependent dynamics with particularly low levels in extremely premature infants. In infants with a GA <26 + 1 weeks using GA-adapted reference values, the sensitivity for discriminating moderate NEC from healthy infants and infants with intestinal distress was 0.89 for a cut-off of 180 and 210 µg/g, respectively, at onset of symptoms. Specificity was 0.96 and 0.84. Fulminant NEC was characterized by unusually low fCP concentrations with a cut-off of <24 µg/g having a sensitivity of 0.84 and a specificity of 0.72 for identifying those cases. Conclusions: fCP levels depend on gestational and postnatal age and in contrast to adults, there is a lower limit in premature infants. Taking these observations into account when defining reference values and interpreting fCP data in the clinical context, fCP can be a useful marker in identifying premature infants with gastrointestinal distress and NEC in particular.

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Dynamic Change of Fecal Calprotectin in Very Low Birth Weight Infants during the First Month of Life

Cited by 71 publications

References 37 publications

Feeding Intolerance in Preterm Neonates in Neonatal Intensive Care Unit, Padma General hospital, Dhaka

Feeding Intolerance in Preterm Neonates in Neonatal Intensive Care Unit, Padma General hospital, Dhaka

Relationships of Feeding and Mother's Own Milk with Fecal Calprotectin Levels in Preterm Infants

Fecal Calprotectin Concentrations in Premature Infants Have a Lower Limit and Show Postnatal and Gestational Age Dependence

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