Dynamic Blood Oxygen Level-dependent MR Imaging of Muscle: Comparison of Postocclusive Reactive Hyperemia in Young Smokers and Nonsmokers

Nishii, Tatsuya; Kono, Atsushi K.; Nishio, Motohiro; Kyotani, Katsusuke; Nishiyama, Kouya; Sugimura, Kazuro

doi:10.2463/mrms.2014-0105

Cited by 9 publications

(6 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In agreement with the results from brief MVCs, TTP of the postocclusive BOLD response was markedly delayed (~54%) at 48 h. These results extend previous findings of attenuated FMD in conduit arteries following eccentric exercise (Stacy et al, ; Caldwell et al, ) by showing slowed reactive hyperemia in the microvasculature. Delayed TTP of the postocclusive BOLD response have been demonstrated in patients with peripheral arterial disease (Ledermann et al, ), systemic sclerosis (Partovi et al, ) and smokers (Nishii et al, ), compared to age‐matched controls, indicating that delayed TTP indeed is related to dysfunction of the microvasculature.…”

Section: Discussionmentioning

confidence: 97%

Impaired microvascular reactivity after eccentric muscle contractions is not restored by acute ingestion of antioxidants or dietary nitrate

et al. 2019

View full text Add to dashboard Cite

Unaccustomed eccentric exercise leads to impaired microvascular function but the underlying mechanism is unknown. In this study, we evaluated the role of oxidative stress and of nitric oxide (NO) bioavailability. Thirty young men and women performed eccentric contractions of the tibialis anterior (TA) muscle (ECC), with the contralateral leg serving as nonexercising control (CON). Participants were randomized into three groups ingesting an antioxidant cocktail (AO), beetroot juice (BR) or placebo 46 h postexercise. At baseline and 48 h postexercise, hyperemic responses to brief muscle contractions and 5 min of cuff occlusion were assessed bilaterally in the TA muscles using blood oxygen level dependent (BOLD) magnetic resonance imaging. Eccentric contractions resulted in delayed time‐to‐peak (~22%; P < 0.001), blunted peak (~21%; P < 0.001) and prolonged time‐to‐half relaxation (~12%, P < 0.001) in the BOLD response to brief contractions, with no effects of AO or BR, and no changes in CON. Postocclusive time‐to‐peak was also delayed (~54%; P < 0.001) in ECC, with no effects of AO or BR, and no changes in CON. Impaired microvascular reactivity after eccentric contractions is confined to the exercised tissue, and is not restored with acute ingestion of AO or BR. Impairments in microvascular reactivity after unaccustomed eccentric contractions may result from structural changes within the microvasculature that can diminish muscle blood flow regulation during intermittent activities requiring prompt adjustments in oxygen delivery.

show abstract

Section: Discussionmentioning

confidence: 97%

Impaired microvascular reactivity after eccentric muscle contractions is not restored by acute ingestion of antioxidants or dietary nitrate

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Previous studies have demonstrated differential BOLD-MRI perfusion parameter responses in different muscles groups in patients both with and without PAOD [20,21]. This variation may be attributed to differences in physical activity, smoking status and/or agerelated structural and metabolic changes in skeletal muscles [22][23][24]. Possible confounding effects that can influence T2* signal changes in muscle tissue, such as age, smoking state, muscle fiber types and simultaneous diabetes or renal disease, are of interest to study further.…”

Section: Discussionmentioning

confidence: 99%

“…It is believed that tissue oxygenation state is multifactorial and can be influenced by lactate, blood volume or hemoglobin concentration. Muscle flow response was studied by Nishii et al using the BOLD-MRI technique in young smokers and non-smokers and significantly higher TTP values were observed in non-smokers [24]. That could potentially be explained by the pathophysiological changes in muscle tissue induced by smoking (i.e., increased oxygen extraction) rather than structural tissue changes in this young population.…”

Section: Discussionmentioning

confidence: 99%

A Reperfusion BOLD-MRI Tissue Perfusion Protocol Reliably Differentiate Patients with Peripheral Arterial Occlusive Disease from Healthy Controls

Törngren

Eriksson

Arvidsson

et al. 2021

JCM

View full text Add to dashboard Cite

There is no established technique that directly quantifies lower limb tissue perfusion. Blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) is an MRI technique that can determine skeletal muscle perfusion. BOLD-MRI relies on magnetic differences of oxygenated and deoxygenated hemoglobin, and regional changes in oxy/deoxyhemoglobin ratio can be recorded by T2* weighted MRI sequences. We aimed to test whether BOLD-MRI can differentiate lower limb tissue perfusion in peripheral arterial occlusive disease (PAOD) patients and healthy controls. Twenty-two PAOD patients and ten healthy elderly volunteers underwent lower limb BOLD-MRI. Reactive hyperemia was provoked by transient cuff compression and images of the gastrocnemius and soleus muscles were continuously acquired at rest, during ischemia and reperfusion. Key BOLD parameters were baseline T2* absolute value and time to T2* peak value after cuff deflation (TTP). Correlations between imaging parameters and ankle-brachial index (ABI) was investigated. The mean TTP was considerably prolonged in PAOD patients compared to healthy controls (m. gastrocnemius: 111 ± 46 versus 48 ± 22 s, p = 0.000253; m. soleus: 100 ± 42 versus 41 ± 30 s, p = 0.000216). Both gastrocnemius and soleus TTP values correlated strongly with ABI (−0.82 and −0.78, p < 0.01). BOLD-MRI during reactive hyperemia differentiated most PAOD patients from healthy controls. TTP was the most decisive parameter and strongly correlated with the ABI.

show abstract

“…Early manifestations of endothelial dysfunction, even in the absence of overt cardiovascular disease, have been observed with BOLD MRI. In general, those with risk factors for cardiovascular disease such as older subjects versus younger individuals (Schulte et al, 2008;Kos et al, 2009) and smokers compared to nonsmokers (Nishii et al, 2015), demonstrated a blunting and delay of the BOLD response following induced ischemia (i.e., reactive hyperemia). In addition, impaired vascular function has been observed from BOLD imaging in clinically overt diseases including peripheral artery disease (PAD) (Ledermann et al, 2006;Englund et al, 2015;Li et al, 2016;Bakermans et al, 2019), critical limb ischemia (CLI) (Huegli et al, 2008), and systemic sclerosis (Partovi et al, 2012b(Partovi et al, , 2013.…”

Section: Bold Mri To Assess Capillary Oxygen Contentmentioning

confidence: 99%

Quantitative and Dynamic MRI Measures of Peripheral Vascular Function

Englund

Langham

2020

Front. Physiol.

View full text Add to dashboard Cite

The endothelium regulates and mediates vascular homeostasis, allowing for dynamic changes of blood flow in response to mechanical and chemical stimuli. Endothelial dysfunction underlies many diseases and is purported to be the earliest pathologic change in the progression of atherosclerotic disease. Peripheral vascular function can be interrogated by measuring the response kinetics following induced ischemia or exercise. In the presence of endothelial dysfunction, there is a blunting and delay of the hyperemic response, which can be measured non-invasively using a variety of quantitative magnetic resonance imaging (MRI) methods. In this review, we summarize recent developments in non-contrast, proton MRI for dynamic quantification of blood flow and oxygenation. Methodologic description is provided for: blood oxygenationlevel dependent (BOLD) signal that reflect combined effect of blood flow and capillary bed oxygen content; arterial spin labeling (ASL) for quantification of regional perfusion; phase contrast (PC) to quantify arterial flow waveforms and macrovascular blood flow velocity and rate; high-resolution MRI for luminal flow-mediated dilation; and dynamic MR oximetry to quantify oxygen saturation. Overall, results suggest that these dynamic and quantitative MRI methods can detect endothelial dysfunction both in the presence of overt cardiovascular disease (such as in patients with peripheral artery disease), as well as in sub-clinical settings (i.e., in chronic smokers, non-smokers exposed to e-cigarette aerosol, and as a function of age). Thus far, these tools have been relegated to the realm of research, used as biomarkers of disease progression and therapeutic response. With proper validation, MRI-measures of vascular function may ultimately be used to complement the standard clinical workup, providing additional insight into the optimal treatment strategy and evaluation of treatment efficacy.

show abstract

Dynamic Blood Oxygen Level-dependent MR Imaging of Muscle: Comparison of Postocclusive Reactive Hyperemia in Young Smokers and Nonsmokers

Cited by 9 publications

References 34 publications

Impaired microvascular reactivity after eccentric muscle contractions is not restored by acute ingestion of antioxidants or dietary nitrate

Impaired microvascular reactivity after eccentric muscle contractions is not restored by acute ingestion of antioxidants or dietary nitrate

A Reperfusion BOLD-MRI Tissue Perfusion Protocol Reliably Differentiate Patients with Peripheral Arterial Occlusive Disease from Healthy Controls

Quantitative and Dynamic MRI Measures of Peripheral Vascular Function

Contact Info

Product

Resources

About