Dynamic bidirectional regulation of NLRC3 and gammaherpesviruses during viral latency in B lymphocytes
Hye‐Ri Kang,
Ji Ho Han,
Yee Ching Ng
et al.
Abstract:While most NOD‐like receptors (NLRs) are predominately expressed by innate immune cells, NLRC3, an inhibitory NLR of immune signaling, exhibits the highest expression in lymphocytes. The role of NLRC3 or any NLRs in B lymphocytes is completely unknown. Gammaherpesviruses, including human Epstein–Barr virus (EBV) and murine gammaherpesvirus 68 (MHV‐68), establish latent infection in B lymphocytes, which requires elevated NF‐κB. This study shows that during latent EBV infection of human B cells, viral‐encoded la… Show more
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