Dynamic associations between tau aggregation, atrophy, and cognitive decline in Alzheimer’s disease
Ellen Hanna Singleton,
Niklas Mattsson-Carlgren,
Alexa Pichet Binette
et al.
Abstract:Tau aggregation measured with PET and neurodegeneration measured with MRI are closely associated with cognitive decline in Alzheimer’s disease, but the independent contributions of baseline and longitudinal measures of these imaging markers to cognitive decline remain unclear. Here, we tested a) independent associations between baseline and rate of change in tau-PET or MRI and cognitive decline, b) relative contributions of baseline and rate of change in tau-PET or MRI vs cognitive decline and c) effects of si… Show more
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