2021
DOI: 10.1007/s12072-021-10221-7
|View full text |Cite
|
Sign up to set email alerts
|

Dynamic assessments of hepatic encephalopathy and ammonia levels predict mortality in acute-on-chronic liver failure

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

1
8
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 33 publications
(13 citation statements)
references
References 19 publications
1
8
0
Order By: Relevance
“…8 Recently, ammonia levels have been shown to be an independent predictor of mortality in patients with acute decompensation or acute-on-chronic liver failure irrespective of the severity of HE, suggesting that it may be a useful biomarker for predicting other liver-related complications. [9][10][11][12] We hypothesised that hyperammonaemia is a risk factor for the development of not only HE but also other liver-related complications and consequent mortality in clinically stable outpatients with cirrhosis. In this study, our primary aim was to determine whether ammonia levels define the risk of subsequent hospitalisation with liver-related complications such as bacterial infection, variceal bleeding, overt HE and ascites.…”
Section: Introductionmentioning
confidence: 99%
“…8 Recently, ammonia levels have been shown to be an independent predictor of mortality in patients with acute decompensation or acute-on-chronic liver failure irrespective of the severity of HE, suggesting that it may be a useful biomarker for predicting other liver-related complications. [9][10][11][12] We hypothesised that hyperammonaemia is a risk factor for the development of not only HE but also other liver-related complications and consequent mortality in clinically stable outpatients with cirrhosis. In this study, our primary aim was to determine whether ammonia levels define the risk of subsequent hospitalisation with liver-related complications such as bacterial infection, variceal bleeding, overt HE and ascites.…”
Section: Introductionmentioning
confidence: 99%
“…[4,5] Elevated ammonia levels play a vital role in the occurrence and development of HE owing to the reduced metabolic capacity of the liver. [6] Gut microbiome dysregulation is linked to numerous diseases and pro-inflammatory states, such as irritable bowel syndrome, rheumatoid arthritis, systemic lupus erythematosus and liver cirrhosis. [7,8] In the presence of gut microbiome dysregulation, the immune system could be erroneously directed in favor of pro-inflammatory pathways to instigate different diseases.…”
Section: Introductionmentioning
confidence: 99%
“…[ 4 , 5 ] Elevated ammonia levels play a vital role in the occurrence and development of HE owing to the reduced metabolic capacity of the liver. [ 6 ]…”
Section: Introductionmentioning
confidence: 99%
“…Consistent with our study, Verma et al . 17 found that ammonia level was a significant predictor of HE occurrence and HE classification; in addition to the above-mentioned factors, they also identified ammonia, lactate, and systemic inflammatory response syndrome as independent predictors of 30-day mortality in patients with ACLF. Elevated WBC counts suggest potential infection, and the CLIF C-ACLF model incorporates WBC in the calculation equation, with high levels of WBC associated with increased risk of ACLF mortality.…”
Section: Discussionmentioning
confidence: 92%