Dynamic assembly of molecularly imprinted polymer nanoparticles

Gong, Haiyue; Hajizadeh, Solmaz; Jiang, Lingdong; Ma, Huiting; Ye, Lei

doi:10.1016/j.jcis.2017.09.046

Cited by 21 publications

(21 citation statements)

References 35 publications

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“…Compared with the FT‐IR spectra of ACVA and TRIM shown in Figure S1, the –C=C band at 1636 cm −1 from the polymer particles has weakened substantially, suggesting that the cross‐linking polymerization has taken place during the imprinting reaction. The change of IR spectrum of the MIP particles before and after template removal, in particular for the naphthalene bands at 1596, 1580, and 1509 cm −1 , indicates that the template has been removed after the washing steps …”

Section: Resultsmentioning

confidence: 99%

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Synthesis of molecularly imprinted polymers using a functionalized initiator for chiral‐selective recognition of propranolol

Liu

Holdsworth

2020

Chirality

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We present a new concept of synthesis for preparation of molecularly imprinted polymers using a functionalized initiator to replace the traditional functional monomer. Using propranolol as a model template, a carboxyl‐functionalized radical initiator was demonstrated to lead to high‐selectivity polymer particles prepared in a standard precipitation polymerization system. When a single enantiomer of propranolol was used as template, the imprinted polymer particles exhibited clear chiral selectivity in an equilibrium binding experiment. Unlike the previous molecular imprinting systems where the active free radicals can be distant from the template‐functional monomer complex, the method reported in this work makes sure that the actual radical polymerization takes place in the vicinity of the template‐associated functional groups. The success of using functional initiator to synthesize molecularly imprinted polymers brings in new possibilities to improve the functional performance of molecularly imprinted synthetic receptors.

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Section: Resultsmentioning

confidence: 99%

“…The change of IR spectrum of the MIP particles before and after template removal, in particular for the naphthalene bands at 1596, 1580, and 1509 cm −1 , indicates that the template has been removed after the washing steps. 23…”

Section: Characterization Of Mip Particlesmentioning

confidence: 99%

Synthesis of molecularly imprinted polymers using a functionalized initiator for chiral‐selective recognition of propranolol

Liu

Holdsworth

2020

Chirality

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“…[11] Usually, to keep the sues, the developments of advanced functional nano-MIPs are significant because of their small size and regular shape. [15,16] In particular, spherical MIP nanoparticles with diameters typically below 200 nm have drawn great attention because of their high surface-area-to-volume ratio, easy removal of templates, rapid binding kinetics, good dispersion, handling ability, and high compatibility with various nano-devices and in vivo biomedical applications. [17] Generally, spherical particles are usually to be prepared by precipitation polymerization.…”

Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Nanoparticles Synthesized by Electrochemically Mediated Atom Transfer Radical Precipitation Polymerization

2022

Macro Chemistry & Physics

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Nanometer molecularly imprinted polymers (nano‐MIPs) spherical particles with specific recognition of sialic acid (SA) are synthesized by electrochemically mediated atomic transfer radical polymerization combined with the precipitation method. SA is used as template molecules,4‐vinylphenylboronicacid as functional monomer, and ethylene glycol dimethacrylate as the crosslinking agent. The successful synthesis of spherical nano‐MIPs is verified by Fourier transform infrared spectroscopy, scanning electron microscope, and Malvern particle size instruments. The effects of the potential adjustment on the morphology, size, and particle size distribution of MIP particles are further investigated. By adjusting the potential for polymerization, nanoparticles with average sizes of 160.32, 275.87, and 331.99 nm are obtained. The recognition performance of nano‐MIPs for SA is characterized by a UV–vis spectrophotometer and the satisfactory imprinting factor is 1.54.

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“…SIT can be divided into two kinds of methods: one based on emulsion and precipitation polymerization [14][15][16][17] and the other based on surface graing and crosslinking. 18,19 The latter method is more efficient and is usually dened as a "pre-graing polymerization and post-crosslinking/imprinting" method 19,20 or "graing polymerization synchronized with crosslinking/imprinting" method.…”

Section: Introductionmentioning

confidence: 99%

Novel ionic surface imprinting technology: design and application for selectively recognizing heavy metal ions

Guo

et al. 2019

RSC Adv.

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Traditional bulk polymerization imprinted technology and existing surface imprinted technology have some congenital defects. Therefore, it is necessary to design more efficient surface imprinted technology. In this paper, novel surface imprinting technology with higher imprinting efficiency is well designed. It fully realizes the synchronization of polymer crosslinking and template imprinting. Then the surface imprinted polymers (SIPs) are synthesized using metal ions as a template. The physicochemical characteristics of the SIPs are characterized by scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) studies, Fourier transform infrared spectroscopy (FTIR) and elemental analysis. The adsorption performances and recognition selectivity of the SIPs towards the template are investigated by a batch method. The experimental results show that the SIPs possess excellent adsorption ability and selectivity towards the template. The selectivity coefficients of the SIPs prepared in this study are higher than those of IIPs prepared by other imprinting methods. The adsorption process could be well described by the Lagergren-first-order model and Langmuir monolayer chemical adsorption. The SIPs have good chemical stability and reusability. Consecutive adsorption-desorption experiments show that the exhausted SIPs could be effectively regenerated, and the regenerated SIPs could be reused without a significant reduction in adsorption capacity or selectivity coefficient.

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Dynamic assembly of molecularly imprinted polymer nanoparticles

Cited by 21 publications

References 35 publications

Synthesis of molecularly imprinted polymers using a functionalized initiator for chiral‐selective recognition of propranolol

Synthesis of molecularly imprinted polymers using a functionalized initiator for chiral‐selective recognition of propranolol

Molecularly Imprinted Nanoparticles Synthesized by Electrochemically Mediated Atom Transfer Radical Precipitation Polymerization

Novel ionic surface imprinting technology: design and application for selectively recognizing heavy metal ions

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