2022
DOI: 10.3390/brainsci12020250
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Dynamic and Systemic Perspective in Autism Spectrum Disorders: A Change of Gaze in Research Opens to A New Landscape of Needs and Solutions

Abstract: The first step for a harmonious bio-psycho-social framework in approaching autism spectrum disorders (ASD) is overcoming the conflict between the biological and the psychosocial perspective. Biological research can provide clues for a correct approach to clinical practice, assuming that it would lead to the conceptualization of a pathogenetic paradigm able to account for epidemiologic and clinical findings. The upward trajectory in ASD prevalence and the systemic involvement of other organs besides the brain s… Show more

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Cited by 3 publications
(2 citation statements)
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References 285 publications
(412 reference statements)
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“…Encompassing longitudinal data or data from multiple modalities might also increase effect sizes 40 , e.g., combining genetics (heritability was estimated to be around 83% for ASD 59 ), neuroimaging, psychological, and social information. The analysis framework we developed can be readily expanded to integrate with all of these modalities and support the development of a biopsychosocial model for ASD 60 , 61 .…”
Section: Discussionmentioning
confidence: 99%
“…Encompassing longitudinal data or data from multiple modalities might also increase effect sizes 40 , e.g., combining genetics (heritability was estimated to be around 83% for ASD 59 ), neuroimaging, psychological, and social information. The analysis framework we developed can be readily expanded to integrate with all of these modalities and support the development of a biopsychosocial model for ASD 60 , 61 .…”
Section: Discussionmentioning
confidence: 99%
“…Panisi and colleagues describe the pathogenetic model of autism in an epigenetic key and its clinical implications (Panisi et al., 2021). The model also considers the role of the VN as a bottom‐up path that informs the brain about the intestinal environment, influenced by nutrition, immune response, microbial balance, and environmental toxicants (Panisi & Marini, 2022).…”
Section: Empathy Attachment and Neurodevelopmentmentioning
confidence: 99%