Dynamic and steady-state respiratory responses to bicycle exercise

Pearce, D. H.; Milhorn, H. Thomas

doi:10.1152/jappl.1977.42.6.959

Cited by 70 publications

(39 citation statements)

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“…WIGERTZ (1970) reported a time constant of 70 sec for VE. The investigators using square-wave forcings including our previous study (MIYAM0T0 et al, 1982) also reported comparable time constants or half-response times (CERRETELLI et al, 1966;HAGBERG et al, 1980;LINNARSSON, 1974;PEARCE and MILHORN, 1977). The kinetics of respiratory variables to impulse stimuli may be better described by a second-order model which is quite similar in nature to that for circulatory kinetics.…”

Section: Methodsmentioning

confidence: 59%

Cardiorespiratory dynamics during sinusoidal and impulse exercise in man.

Miyamoto

Nakazono

et al. 1983

Jpn.J.Physiol

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Dynamic characteristics of ventilation, cardiac output, and gas exchange during sinusoidally varying work rates for the periods from 1 to 12 min and impulse work rate with a duration of 10 sec were studied on five healthy men in an upright position. Changes in work rate were given by controlling externally the electromagnetic braking system of a bicycle ergometer. Stroke volume, heart rate, and cardiac output during exercise were determined continuously by using an automated impedance cardiograph. Breath by breath determination in minute ventilation, respiratory frequency, tidal volume, oxygen consumption, carbon dioxide output, end-tidal pressures of oxygen and carbon dioxide, and gas exchange ratio were conducted. From these and steady-state response data amplitude and phase relations between each variable and the input work loads were obtained utilizing the frequency analysis techniques. The response characteristics to sinusoidal stimuli were well represented by first-order models with time constants for VE, Vcoz, V o ,, and Q averaging 75, 67, 52, and 36 sec, respectively. The kinetics of HR closely resembled that of Q. There was a close link between both the dynamics of VE and Vco 2. On the other hand, the responses to impulse stimuli were better described by second-order models in which fast and slow response components were connected in parallel. However, the contribution of the fast component to total response was small. Although this response may support in its form the neurohumoral concept to explain exercise hyperpnea, a tight linkage was observed between VE and VCO2 responses to impulse stimuli. Thus, hyperpnea during the unsteady-state of exercise may be explained by the cardiodynamic hypothesis.

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Section: Methodsmentioning

confidence: 59%

Cardiorespiratory dynamics during sinusoidal and impulse exercise in man.

Miyamoto

Nakazono

et al. 1983

Jpn.J.Physiol

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“…6). Neither was there in previous studies that compared on-and off-transient ventilatory dynamics in exercising man (Linnarsson, 1974;Pearce & Millhorn, 1977;Lamarra, Whipp, Blumenberg & Wasserman, 1983). This contention is further supported by the observation that the ventilatory dynamics in response to sinusoidal exercise forcings are well described by a single-exponential model (Casaburi et al 1977;Miyamoto et al 1983).…”

Section: Discussionmentioning

confidence: 94%

Influence of inspired oxygen concentration on the dynamics of the exercise hyperpnoea in man.

Griffiths¹,

Henson²,

Whipp³

1986

The Journal of Physiology

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“…Thus the time constant of the exponential function for Vo2, V, and Vco2 increases in this order. Difference in the J'02 and J'co2 kinetics elicits transient hypoxla (BJURSTEDT and WIGERTZ, 1971;PEARCE and MILHORN, 1977;YOUNG and WOOLCOCK, 1978;ODENBURG et al, 1979), and difference in the V and Vco2 kinetics elicits transient hypercapnia (WHIPP, 1981).…”

Section: Discussionmentioning

confidence: 99%

Estimation of peripheral chemoreceptor contribution to exercise hyperpnea in man.

et al. 1988

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Nine normal male subjects were studied at three levels of exercise (0, 40, and 80W). Single vital capacity breath test was applied at rest and during exercise (phases 2 and 3). Minimum minute ventilation found within 4 breaths following the test was compared to the control value. Significant depression in minute ventilation was invariably observed. The minute ventilation was depressed more and more with increasing intensity of exercise. A significant difference was found between exercise and rest. However, the relative contribution of chemoreceptor activity remained the same l0-20° at all exercise levels. The magnitude of ventilatory depression (d Vresp) in phase 2 was larger than that in phase 3, when work rate increased to 80 W, both relative and absolute.A significant part of the exercise hyperpnea is due to peripheral chemoreceptor activity. The peripheral chemoreceptor activity is greater in phase 2 than in phase 3 at work rates of light to moderate intensity.

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Dynamic and steady-state respiratory responses to bicycle exercise

Cited by 70 publications

References 0 publications

Cardiorespiratory dynamics during sinusoidal and impulse exercise in man.

Cardiorespiratory dynamics during sinusoidal and impulse exercise in man.

Influence of inspired oxygen concentration on the dynamics of the exercise hyperpnoea in man.

Estimation of peripheral chemoreceptor contribution to exercise hyperpnea in man.

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