Dynamic alterations of spontaneous neural activity in patients with amyotrophic lateral sclerosis

Ma, Xiaoli; Lu, Fengmei; Hu, Caihong; Wang, Jiao; Zhang, Sheng; Zhang, Shuqin; Yang, Guiran; Zhang, Jiuquan

doi:10.1007/s11682-020-00405-4

Cited by 7 publications

(12 citation statements)

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“…Similarly, another study reported decreased FC in the bilateral hippocampus, bilateral anterior and posterior PhG, and posterior cingulate in ALS patients 58 . Additionally, Ma et al 48 . found a lower d‐ReHo in the left rectus gyrus and the left PhG in patients with ALS compared to HCs.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, the decreased FC in the hippocampal and PhG regions can indicate disrupted neural networks and potential neurodegeneration in ALS patients. 47,48,58 These results suggest that ALS has a broader impact on brain function beyond motor function.…”

Section: Hippocampal and Parahippocampal Regions' Involvement In Alsmentioning

confidence: 87%

“…Based on fMRI findings, changes in FC, Reho, and ALFF of brain activity in the hippocampal and PhG regions suggest that ALS affects not only motor function but also other cognitive and emotional processes. 47,48,58,64,66,69,72,74,78 The emotional processing differences that Aho-Özhan et al 66 found suggest that ALS patients can have unique responses to emotional stimuli, which could be related to the observed alterations in hippocampal function and connectivity. Furthermore, the decreased FC in the hippocampal and PhG regions can indicate disrupted neural networks and potential neurodegeneration in ALS patients.…”

Section: Hippocampal and Parahippocampal Regions' Involvement In Alsmentioning

confidence: 99%

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MRI biomarkers and neuropsychological assessments of hippocampal and parahippocampal regions affected by ALS: A systematic review

Mohammadi,

Ghaderi,

Fatehi

2024

CNS Neurosci Ther

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Background and ObjectiveAmyotrophic lateral sclerosis (ALS) is a progressive motor and extra‐motor neurodegenerative disease. This systematic review aimed to examine MRI biomarkers and neuropsychological assessments of the hippocampal and parahippocampal regions in patients with ALS.MethodsA systematic review was conducted in the Scopus and PubMed databases for studies published between January 2000 and July 2023. The inclusion criteria were (1) MRI studies to assess hippocampal and parahippocampal regions in ALS patients, and (2) studies reporting neuropsychological data in patients with ALS.ResultsA total of 46 studies were included. Structural MRI revealed hippocampal atrophy, especially in ALS‐FTD, involving specific subregions (CA1, dentate gyrus). Disease progression and genetic factors impacted atrophy patterns. Diffusion tensor imaging (DTI) showed increased mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD), and decreased fractional anisotropy (FA) in the hippocampal tracts and adjacent regions, indicating loss of neuronal and white matter integrity. Functional MRI (fMRI) revealed reduced functional connectivity (FC) between the hippocampus, parahippocampus, and other regions, suggesting disrupted networks. Perfusion MRI showed hypoperfusion in parahippocampal gyri. Magnetic resonance spectroscopy (MRS) found changes in the hippocampus, indicating neuronal loss. Neuropsychological tests showed associations between poorer memory and hippocampal atrophy or connectivity changes. CA1‐2, dentate gyrus, and fimbria atrophy were correlated with worse memory.ConclusionsThe hippocampus and the connected regions are involved in ALS. Hippocampal atrophy disrupted connectivity and metabolite changes correlate with cognitive and functional decline. Specific subregions can be particularly affected. The hippocampus is a potential biomarker for disease monitoring and prognosis.

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Section: Resultsmentioning

confidence: 99%

Section: Hippocampal and Parahippocampal Regions' Involvement In Alsmentioning

confidence: 87%

Section: Hippocampal and Parahippocampal Regions' Involvement In Alsmentioning

confidence: 99%

See 1 more Smart Citation

MRI biomarkers and neuropsychological assessments of hippocampal and parahippocampal regions affected by ALS: A systematic review

Mohammadi,

Ghaderi,

Fatehi

2024

CNS Neurosci Ther

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“…21 These indicators were also proven to correlate with disease progression in other diseases through general linear models or machine learning approaches and are considered potential diagnostic markers. [22][23][24] However, fMRI is still used as an additional resource in conjunction with other tests. We speculate that ALFF/ fALFF and ReHo may be promising imaging markers for the early diagnosis of AD.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Resting-state functional reorganisation in Alzheimer’s disease and amnestic mild cognitive impairment: protocol for a systematic review and meta-analysis

Lyu

2021

BMJ Open

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IntroductionThe incidence of Alzheimer’s disease (AD) is increasing rapidly, causing a growing burden to health and economic worldwide. Several clinical trials in the past decade failed to find solutions, and there remains a lack of an effective treatment. The evidence suggests that early intervention for neurodegeneration would likely be effective in preventing cognitive decline. Cognitive decline in AD occurs continuously over a long period; however, there remains a lack of simple, rapid and accurate approach for diagnosis of amnestic mild cognitive impairment or subjective cognitive decline due to underlying Alzheimer’s pathology. Resting-state functional MRI (rs-fMRI) determines the functional activities of the human brain non-invasively. The amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF) and regional homogeneity (ReHo) are rs-fMRI indicators with high repeatability. They have been studied as early diagnostic imaging markers for other diseases and may be promising markers also for AD.Methods and analysisThe following electronic literature databases will be searched from inception to December 2021: Medline-Ovid, Medline-PubMed, EMBase-Ovid, Cochrane Central and ClinicalTrials.gov. Two independent reviewers will select studies with eligible criteria, extract data and assess the quality of the original studies with our quality assessment tool individually. Missing data will be requested by sending emails to the corresponding authors. Brain regions will be presented for ALFF/fALFF and ReHo by performing activation likelihood estimation with the Seed-based d Mapping-Permutation of subject images V.6.21 software. Meta-regression will be performed to determine the potential brain regions that may strongly correlate with cognitive decline progression. Subgroup analysis, funnel plot, Egger’s test and sensitivity analysis will be conducted to detect and explain potential heterogeneity.Ethics and disseminationThis study does not require formal ethical approval. The findings will be submitted to a peer-review journal.PROSPERO registration numberCRD42021229009.

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“…These studies suggested that ReHo can be applied to localize abnormal brain regions in OSA patients. However, some literature has shown that brain activity at rest is a dynamic process and is related to specific functions (Zou et al, 2015;Ma X. et al, 2021). Resting-state ReHo assumes that the blood oxygen level-dependent signal is stable throughout the rs-fMRI scan while ignoring the characteristics of dynamic changes in brain activity over time (Yu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Dynamic regional homogeneity alterations and cognitive impairment in patients with moderate and severe obstructive sleep apnea

Shu

Liu

et al. 2022

Front. Neurosci.

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Background and purposePrevious studies have found that abnormal local spontaneous brain activity in patients with obstructive sleep apnea (OSA) was associated with cognitive impairment, and dynamic functional connections can capture the time changes of functional connections during magnetic resonance imaging acquisition. The purpose of this study was to investigate the dynamic characteristics of regional brain connectivity and its relationship with cognitive function in patients with OSA and to explore whether the dynamic changes can be used to distinguish them from healthy controls (HCs).MethodsSeventy-nine moderate and severe male OSA patients without any treatment and 84 HCs with similar age and education were recruited, and clinical data and resting functional magnetic resonance imaging data were collected. The dynamic regional homogeneity (dReHo) was calculated using a sliding window technique, and a double-sample t-test was used to test the difference in the dReHo map between OSA patients and HCs. We explored the relationship between dReHo and clinical and cognitive function in OSA patients using Pearson correlation analysis. A support vector machine was used to classify the OSA patients and HCs based on abnormal dReHo.ResultCompared with HCs, OSA patients exhibited higher dReHo values in the right medial frontal gyrus and significantly lower dReHo values in the right putamen, right superior temporal gyrus, right cingulate gyrus, left insula and left precuneus. The correlation analysis showed that the abnormal dReHo values in multiple brain regions in patients with OSA were significantly correlated with nadir oxygen saturation, the oxygen depletion index, sleep period time, and Montreal cognitive assessment score. The support vector machine classification accuracy based on the dReHo difference in brain regions was 81.60%, precision was 81.01%, sensitivity was 81.01%, specificity was 82.14%, and area under the curve was 0.89.ConclusionThe results of this study suggested that there was abnormal dynamic regional spontaneous brain activity in patients with OSA, which was related to clinical and cognitive evaluation and can be used to distinguish OSA patients from HCs. The dReHo is a potential objective neuroimaging marker for patients with OSA that can further the understanding of the neuropathological mechanism of patients with OSA.

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Dynamic alterations of spontaneous neural activity in patients with amyotrophic lateral sclerosis

Cited by 7 publications

References 58 publications

MRI biomarkers and neuropsychological assessments of hippocampal and parahippocampal regions affected by ALS: A systematic review

MRI biomarkers and neuropsychological assessments of hippocampal and parahippocampal regions affected by ALS: A systematic review

Resting-state functional reorganisation in Alzheimer’s disease and amnestic mild cognitive impairment: protocol for a systematic review and meta-analysis

Dynamic regional homogeneity alterations and cognitive impairment in patients with moderate and severe obstructive sleep apnea

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