2022
DOI: 10.1002/bit.28189
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Dynamic alterations of metabolites revealed the vascularization progression of bioengineered liver

Abstract: Vascularization is a critical but challenging process in developing functional bioengineered livers with the decellularized liver scaffolds (DLSs) and the process is accompanied by cell-specific metabolic alterations. To elucidate the dynamic alterations of metabolites during vascularization, rat DLSs were vascularized with human umbilical vein endothelial cells and liquid chromatography mass spectrometrybased metabolomics was performed on culture supernatants collected at 0, 1, 3, 7, 14, and 21 days. Overall,… Show more

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