Dynamic Alterations of Amplitude of Low-Frequency Fluctuations in Patients With Drug-Naïve First-Episode Early Onset Schizophrenia

Li, Qiang; Cao, Xiaohua; Li, Sha; Li, Zexuan; Wang, Yanfang; Cheng, Long; Yang, Chongguang; Xu, Yong

doi:10.3389/fnins.2020.00901

Cited by 15 publications

(10 citation statements)

References 71 publications

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“…The ALFF method has been applied to evaluate the neural mechanisms of central disease including schizophrenia ( 21 ), epilepsy ( 22 ), mild cognitive impairment ( 23 ), and migraine ( 24 ). Besides, many studies have suggested that the ALFF of fMRI signals are closely related to the spontaneous neuronal activities such as visual cortex ( 25 ), auditory cortex ( 26 ), hippocampus ( 27 ), cingulate cortex, and postcentral gyrus ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

The Association Between Precuneus Function and Residual Dizziness in Patients With Benign Paroxysmal Positional Vertigo

Bai

et al. 2022

Front. Neurol.

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ObjectivesThe purpose of this study was to apply the amplitude of the low-frequency fluctuation (ALFF) method to investigate the spontaneous brain activity alterations in patients with residual dizziness (RD) after successful canalith repositioning manoeuvre for benign paroxysmal positional vertigo (BPPV).MethodsAll BPPV patients underwent visual vertigo analog scale (VVAS) evaluations and functional magnetic resonance imaging (fMRI). The ALFF method was used to assess the spontaneous brain activity. Screening of brain regions with significant changes in ALFF values was based on analysis of the whole brain. We further analyze the relationship between ALFF values of the altered regions and VVAS scores in BPPV patients with RD.ResultsFifteen BPPV patients with RD and fifteen without RD were recruited in this study. In contrast to without RD, RD patients exhibited increased scores in VVAS tests (p < 0.001) and RD patients also showed significant ALFF decrease in the bilateral precuneus (left: 251 voxels; x = −10, y = −69, z = 51; peak t-value = −3.25; right: 170 voxels; x = 4, y = −59, z = 42; peak t-value = −3.43). Correlation analysis revealed that the mean ALFF z-values in the left precuneus displayed significant negative correlations with the VVAS scores(r = −0.44, p = 0.01).ConclusionsThis study shows that RD is associated with left precuneus function as revealed by fMRI. It might provide useful information for explaining neural mechanisms in BPPV patients with RD.

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Section: Discussionmentioning

confidence: 99%

The Association Between Precuneus Function and Residual Dizziness in Patients With Benign Paroxysmal Positional Vertigo

Bai

et al. 2022

Front. Neurol.

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“…Oscillatory signaling is ubiquitous in vital movement, and precisely controls the sequential behaviors of many important physiological processes [1][2][3], such as circadian rhythm [4], embryonic development [5], neuron electrophysiology [6], and cell cycle [7]. Oscillation behavior of molecules, for instance, calcium ions, tumor suppressor gene p53, p38 MAPK (mitogenactivated protein kinases), and NF-κB (Nuclear Factor-kappa B) in inflammatory response, determines the fate of cells [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Oscillations Governed by the Incoherent Dynamics in Necroptotic Signaling

Yin

Zhu

et al. 2021

Front. Phys.

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Emerging evidences have suggested that oscillation is important for the induction of cell death. However, whether and how oscillation behavior is involved and required for necroptosis remain elusive. To address this question, a minimal necroptotic circuit is proposed based on the CNS pathway. Stochastic parameter analysis demonstrates that the essential structure for oscillation of the CNS circuit is constituted by a paradoxical component embedded with positive feedback among the three protein nodes, i.e., RIP1, caspase-8, and RIP3. Distribution characteristics of all parameters in the CNS circuit with stable oscillation are investigated as well, and a unidirectional bias with fast and slow dynamics that are required for high occurrence probability of oscillation is identified. Four types of oscillation behaviors are classified and their robustness is further explored, implying that the fast oscillation behavior is more robust than the slow behavior. In addition, bifurcation analysis and landscape approach are employed to study stochastic dynamics and global stability of the circuit oscillations, revealing the possible switching strategies among different behaviors. Taken together, our study provides a natural and physical bases for understanding the occurrence of oscillations in the necroptotic network, advancing our knowledge of oscillations in regulating the various cell death signaling.

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“…Previous studies have used VBM and ALFF methods to investigate changes in GMV and local neural activity in patients with schizophrenia ( 44 – 48 ). The TP, MFG, and MTG are the common brain areas consistently reported in previous studies and the current study.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, compared with healthy participants, some studies found that patients with schizophrenia demonstrate decreased GMV in the MFG and paralimbic system (including the orbitofrontal cortex, insular cortex, and TP) ( 44 , 45 ). Li et al found differences in the variability of dynamic ALFF between EOS patients and healthy controls in the bilateral precuneus, right superior marginal gyrus, right postcentral gyrus, and right MTG ( 48 ). However, the investigators focused solely on distinguishing this disease and paid no attention to changes in the global cognitive function of patients.…”

Section: Discussionmentioning

confidence: 99%

Associations of Neurocognition and Social Cognition With Brain Structure and Function in Early-Onset Schizophrenia

Guo

Jiang

et al. 2022

Front. Psychiatry

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BackgroundCognitive impairment is a core feature of schizophrenia that is more serious in patients with early-onset schizophrenia (EOS). However, the neuroimaging basis of cognitive functions, including neurocognition and social cognition, remains unclear in patients with EOS.MethodsForty-three patients with EOS underwent structural and resting state functional magnetic resonance imaging scans. Brain structure and function were evaluated through the analysis of brain gray matter volume (GMV) and amplitude of low-frequency fluctuations (ALFF). They underwent comprehensive assessments for neurocognition (verbal memory, verbal expression, attention, and executive function) and social cognition (theory of mind and attributional bias). Correlation analyses were conducted to detect the potential link between cognitive function indices and brain imaging parameters.ResultsFirst, neurocognition was linked to brain structure characterized by higher immediate recall scores associated with increased GMV in the left temporal pole, higher verbal fluency scores associated with increased GMV in the left temporal pole: middle temporal gyrus, and higher Stroop-word scores associated with increased GMV in the right middle frontal gyrus. Second, social cognition was related to brain function characterized by lower sense of reality scores associated with increased ALFF in the left precentral gyrus, higher scores of accidental hostility bias associated with increased ALFF in the right middle temporal gyrus, and higher scores of accidental aggression bias associated with increased ALFF in the left precentral gyrus.ConclusionThese findings may add to the existing knowledge about the cognitive function-brain relationship. They may have clinical significance for studying the mechanism of neurocognitive and social cognitive impairment in patients with EOS and providing potential neural targets for their treatment and intervention.

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Dynamic Alterations of Amplitude of Low-Frequency Fluctuations in Patients With Drug-Naïve First-Episode Early Onset Schizophrenia

Cited by 15 publications

References 71 publications

The Association Between Precuneus Function and Residual Dizziness in Patients With Benign Paroxysmal Positional Vertigo

The Association Between Precuneus Function and Residual Dizziness in Patients With Benign Paroxysmal Positional Vertigo

Oscillations Governed by the Incoherent Dynamics in Necroptotic Signaling

Associations of Neurocognition and Social Cognition With Brain Structure and Function in Early-Onset Schizophrenia

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