Dynamic Activity of Histone H3-Specific Chaperone Complexes in Oncogenesis

Wen, Ting; Chen, Qiao Yi

doi:10.3389/fonc.2021.806974

Cited by 5 publications

(2 citation statements)

References 136 publications

(211 reference statements)

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“…Chromatin-modifying enzymes communicate and interact with each other 43 , 44 . Cross-talk between different histone modifications also controls chromatin structure 45 .…”

Section: Discussionmentioning

confidence: 99%

Clustering of Chromatin Remodeling Enzymes Predicts Prognosis and Clinical Benefit of Therapeutic Strategy in Pancreatic Cancer

Wang¹,

Shih²,

Wu³

et al. 2022

Int. J. Med. Sci.

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In recent years, translational research and pharmacological targeting of epigenetic modifications have become the focus of personalized therapy for patients with pancreatic cancer. Preclinical and clinical trials targeting post-translational modifications have been evaluated as monotherapy or in combination with standard chemotherapy. In this study, we selected 43 genes from seven families of chromatin-modifying enzymes and investigated the influences of epigenetic modifications and their interactions on pancreatic ductal adenocarcinoma (PDAC) using hierarchical clustering analysis. Our analysis also evaluated their effects on treatment modalities and regimens of chemotherapy for PDAC. RNA-seq data for a total of 177 patients with pancreatic cancer, obtained from The Cancer Genome Atlas database, were analyzed. Our results suggested that high-risk patients of survival significant chromatin remodeling-associated gene cluster (gene cluster 2), composed of histone methyltransferases, histone acetyltransferases, histone deacetylases, histone demethylases, and 10-11 translocation family, demonstrated inferior progression-free survival and overall survival in patients with PDAC, especially in men. Our novel biomarker, survival significant chromatin remodeling-associated gene cluster, showed superior prediction performance compared with the conventional TNM system. Overall, these findings suggest that epigenetic modifications and interactions play an important role in the prognosis and therapeutic response of patients with PDAC.

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“…Chromatin-modifying enzymes communicate and interact with each other 43 , 44 . Cross-talk between different histone modifications also controls chromatin structure 45 .…”

Section: Discussionmentioning

confidence: 99%

Clustering of Chromatin Remodeling Enzymes Predicts Prognosis and Clinical Benefit of Therapeutic Strategy in Pancreatic Cancer

Wang¹,

Shih²,

Wu³

et al. 2022

Int. J. Med. Sci.

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“…The ~147 bp DNA is tightly wrapped around the histone core octamer consisting of H3, H4, H2A, and H2B subunits to form nucleosomes and is further stabilized by the H1 linker histone [1]. The canonical histones and histone variants play a pivotal role in precisely modulating chromatin dynamics and regulating accessibility to specific DNA regions [2]. The nucleosome conveys specific genetic information through covalently modified or incorporated histone variants.…”

Section: Introductionmentioning

confidence: 99%

Independent and Complementary Functions of Caf1b and Hir1 for Chromatin Assembly in Tetrahymena thermophila

Hao,

Ren,

Lian

et al. 2023

Cells

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Histones and DNA associate to form the nucleosomes of eukaryotic chromatin. Chromatin assembly factor 1 (CAF-1) complex and histone regulatory protein A (HIRA) complex mediate replication-couple (RC) and replication-independent (RI) nucleosome assembly, respectively. CHAF1B and HIRA share a similar domain but play different roles in nucleosome assembly by binding to the different interactors. At present, there is limited understanding for the similarities and differences in their respective functions. Tetrahymena thermophila contains transcriptionally active polyploid macronuclei (MAC) and transcriptionally silent diploid micronuclei (MIC). Here, the distribution patterns of Caf1b and Hir1 exhibited both similarities and distinctions. Both proteins localized to the MAC and MIC during growth, and to the MIC during conjugation. However, Hir1 exhibited additional signaling on parental MAC and new MAC during sexual reproduction and displayed a punctate signal on developing anlagen. Caf1b and Hir1 only co-localized in the MIC with Pcna1 during conjugation. Knockdown of CAF1B impeded cellular growth and arrested sexual reproductive development. Loss of HIR1 led to MIC chromosome defects and aborted sexual development. Co-interference of CAF1B and HIR1 led to a more severe phenotype. Moreover, CAF1B knockdown led to the up-regulation of HIR1 expression, while knockdown of HIR1 also led to an increase in CAF1B expression. Furthermore, Caf1b and Hir1 interacted with different interactors. These results showed that CAF-1 and Hir1 have independent and complementary functions for chromatin assembly in T. thermophila.

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Histone Chaperones in Cancer

Shirude,

Dutta

2023

Handbook of Oncobiology: From Basic to Clinical Sciences

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Dynamic Activity of Histone H3-Specific Chaperone Complexes in Oncogenesis

Cited by 5 publications

References 136 publications

Clustering of Chromatin Remodeling Enzymes Predicts Prognosis and Clinical Benefit of Therapeutic Strategy in Pancreatic Cancer

Clustering of Chromatin Remodeling Enzymes Predicts Prognosis and Clinical Benefit of Therapeutic Strategy in Pancreatic Cancer

Independent and Complementary Functions of Caf1b and Hir1 for Chromatin Assembly in Tetrahymena thermophila

Histone Chaperones in Cancer

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