Dynamic 2-deoxy-D-glucose-enhanced multispectral optoacoustic tomography for assessing metabolism and vascular hemodynamics of breast cancer

Zheng, Han; MacCuaig, William M.; Gürcan, Metin N.; Claros-Sorto, Juan; Garwe, Tabitha; Henson, Christina; Holter-Chakrabarty, Jennifer; Hannafon, Bethany N.; Chandra, Vishal; Wellberg, Elizabeth A.; McNally, Lacey R.

doi:10.1016/j.pacs.2023.100531

Cited by 4 publications

(2 citation statements)

References 64 publications

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“…Clinical studies [39] have shown that hybrid MSOT/ultrasound systems possess the capability of nonlabeled imaging of muscle perfusion and oxygenation under conditions of arterial and venous occlusion, and can therefore be used to evaluate vascular disease characterized by blood flow disturbances. Furthermore, the sensitivity of optoacoustic imaging can be significantly enhanced through the utilization of exogenous contrast agents [40][41][42]. Using MSOT to monitor the real-time clearance kinetics of indocyanine green in the liver, a study [43] found that a normal liver can rapidly clear indocyanine green over a short period of time, so organ function and disease severity can be assessed.…”

Section: Discussionmentioning

confidence: 99%

Preclinical multi‐physiologic monitoring of immediate‐early responses to diverse treatment strategies in breast cancer by optoacoustic imaging

Lin,

Yang,

et al. 2024

Journal of Biophotonics

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Optoacoustic imaging enables the measurement of tissue oxygen saturation (sO2) and blood perfusion while being utilized for detecting tumor microenvironments. Our aim was to employ multispectral optoacoustic tomography (MSOT) to assess immediate‐early changes of hemoglobin level and sO2 within breast tumors during diverse treatments. Mouse breast cancer models were allocated into four groups: control, everolimus (EVE), paclitaxel (PTX), and photodynamic therapy (PDT). Hemoglobin was quantified daily, as well as sO2 and blood perfusion were verified by immunohistochemical (IHC) staining. MSOT showed a temporal window of enhanced oxygenation and improved perfusion in EVE and PTX groups, while sO2 consistently remained below baseline in PDT. The same results were obtained for the IHC. Therefore, MSOT can monitor tumor hypoxia and indirectly reflect blood perfusion in a non‐invasive and non‐labeled way, which has the potential to monitor breast cancer progression early and enable individualized treatment in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Preclinical multi‐physiologic monitoring of immediate‐early responses to diverse treatment strategies in breast cancer by optoacoustic imaging

Lin,

Yang,

et al. 2024

Journal of Biophotonics

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“…Furthermore, the ICG signal may be hindered further by blood pooling within the surgical field secondary to blood loss, which is not uncommon in hepatobiliary surgery [79]. Of importance, hemoglobin is one of the few strong endogenous contrast agents that allow for the identification of microvascular changes and tissue oxygenation using MSOT [58,80], and it has been successfully used to monitor tumor responses to antiangiogenic agents in mouse models [81]. Exogenous contrast agents used for OA imaging in preclinical mouse studies include organic dyes, such as ICG, and nanoparticles, such as gold, silver, tungsten, iron oxide, and carbon nanotubes [64,70,71].…”

Section: Photodynamic Imagingmentioning

confidence: 99%

Intraoperative Imaging in Hepatopancreatobiliary Surgery

Husarova,

MacCuaig,

Dennahy

et al. 2023

Cancers

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Hepatopancreatobiliary surgery belongs to one of the most complex fields of general surgery. An intricate and vital anatomy is accompanied by difficult distinctions of tumors from fibrosis and inflammation; the identification of precise tumor margins; or small, even disappearing, lesions on currently available imaging. The routine implementation of ultrasound use shifted the possibilities in the operating room, yet more precision is necessary to achieve negative resection margins. Modalities utilizing fluorescent-compatible dyes have proven their role in hepatopancreatobiliary surgery, although this is not yet a routine practice, as there are many limitations. Modalities, such as photoacoustic imaging or 3D holograms, are emerging but are mostly limited to preclinical settings. There is a need to identify and develop an ideal contrast agent capable of differentiating between malignant and benign tissue and to report on the prognostic benefits of implemented intraoperative imaging in order to navigate clinical translation. This review focuses on existing and developing imaging modalities for intraoperative use, tailored to the needs of hepatopancreatobiliary cancers. We will also cover the application of these imaging techniques to theranostics to achieve combined diagnostic and therapeutic potential.

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Influence of structural moieties in squaraine dyes on optoacoustic signal shape and intensity

MacCuaig,

Wickizer,

Van

et al. 2024

Chem

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Dynamic 2-deoxy-D-glucose-enhanced multispectral optoacoustic tomography for assessing metabolism and vascular hemodynamics of breast cancer

Cited by 4 publications

References 64 publications

Preclinical multi‐physiologic monitoring of immediate‐early responses to diverse treatment strategies in breast cancer by optoacoustic imaging

Preclinical multi‐physiologic monitoring of immediate‐early responses to diverse treatment strategies in breast cancer by optoacoustic imaging

Intraoperative Imaging in Hepatopancreatobiliary Surgery

Influence of structural moieties in squaraine dyes on optoacoustic signal shape and intensity

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