Dye-Cucurbit[<i>n</i>]uril Complexes as Sensor Elements for Reliable Pattern Recognition of Biogenic Polyamines

Park, Kyeng Min; Kim, Jeeyeon; Ko, Young Ho; Ahn, Youngjoo; Murray, James; Li, Meng; Shrinidhi, Annadka; Kim, Kimoon

doi:10.1246/bcsj.20170302

Cited by 31 publications

(16 citation statements)

References 41 publications

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“…Kim and co-workers fabricated sensor arrays that were engineered with fluorescence dyes and cucurbit[ n ]urils ( n = 6, 7 and 8) as host systems [91]. The obtained sensors were used for sensing biogenic amines with the aid of principal component analysis.…”

Section: Reviewmentioning

confidence: 99%

Review of advanced sensor devices employing nanoarchitectonics concepts

Ariga¹,

Makita²,

Watanabe³

et al. 2019

Beilstein J. Nanotechnol.

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Many recent advances in sensor technology have been possible due to nanotechnological advancements together with contributions from other research fields. Such interdisciplinary collaborations fit well with the emerging concept of nanoarchitectonics, which is a novel conceptual methodology to engineer functional materials and systems from nanoscale units through the fusion of nanotechnology with other research fields, including organic chemistry, supramolecular chemistry, materials science and biology. In this review article, we discuss recent advancements in sensor devices and sensor materials that take advantage of advanced nanoarchitectonics concepts for improved performance. In the first part, recent progress on sensor systems are roughly classified according to the sensor targets, such as chemical substances, physical conditions, and biological phenomena. In the following sections, advancements in various nanoarchitectonic motifs, including nanoporous structures, ultrathin films, and interfacial effects for improved sensor function are discussed to realize the importance of nanoarchitectonic structures. Many of these examples show that advancements in sensor technology are no longer limited by progress in microfabrication and nanofabrication of device structures – opening a new avenue for highly engineered, high performing sensor systems through the application of nanoarchitectonics concepts.

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Section: Reviewmentioning

confidence: 99%

Review of advanced sensor devices employing nanoarchitectonics concepts

Ariga¹,

Makita²,

Watanabe³

et al. 2019

Beilstein J. Nanotechnol.

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show abstract

“…The holes can preferentially entrap graphitic objects, probably due to surface π-π interaction. Although molecular-level recognition is a common subject [81,82], microscopic-level recognition for micron-sized particles has not been fully explored. The found example would open a novel category of microscopic materials recognition.…”

Section: Holes In Cubementioning

confidence: 99%

Fullerene Nanoarchitectonics with Shape-Shifting

Ariga

Shrestha

2020

Materials

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This short review article introduces several examples of self-assembly-based structural formation and shape-shifting using very simple molecular units, fullerenes (C60, C70, and their derivatives), as fullerene nanoarchitectonics. Fullerene molecules are suitable units for the basic science of self-assembly because they are simple zero-dimensional objects with only a single elemental component, carbon, without any charged or interactive functional groups. In this review article, self-assembly of fullerene molecules and their shape-shifting are introduced as fullerene nanoarchitectonics. An outline and a background of fullerene nanoarchitectonics are first described, followed by various demonstrations, including fabrication of various fullerene nanostructures, such as rods on the cube, holes in the cube, interior channels in the cube, and fullerene micro-horns, and also a demonstration of a new concept, supramolecular differentiation.

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“…Notably, CB [6] has remarkably high binding affinities with SP and SPD (up to 10 12 M −1 ). 49 Apart from a few "host−guest" interaction-based two-component sensors for SP and SPD involving a conventional dye and a CB derivative, 50,51 there is only one report of this kind for spermine using both the "host−guest" interaction and the AIE phenomenon. 52 The sensor reported by Jiang et al 52 is not highly sensitive (LOD is in the micromolar range) as the AIE effect is not well manifested by such discrete two-component entities.…”

Section: ■ Introductionmentioning

confidence: 99%

Solid-Supported Amplification of Aggregation Emission: A Tetraphenylethylene–Cucurbit[6]uril@Hydroxyapatite-Based Supramolecular Sensing Assembly for the Detection of Spermine and Spermidine in Human Urine and Blood

Naik

Kumar

Bhasikuttan

et al. 2021

ACS Appl. Bio Mater.

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The development of sensitive and selective tools for the detection and quantification of biomarkers is important in the diagnosis and treatment of clinical diseases. Spermine (SP) and spermidine (SPD) act as biomarkers for early-stage diagnosis of cancer in humans as their increased levels in urine are indicative of abnormal biological processes associated with this fatal disease. In this study, we introduced a strategy for solid-supported amplification of the effective aggregation-induced-emission (AIE) effect of a water-soluble tetraphenylethylene (TPE)-based probe in developing a supramolecular sensing platform for the rapid, sensitive, and selective detection of SP and SPD in water. The nonemissive TPE derivative (TPEHP) forms a less emissive conjugate with hydroxyl cucurbit[6]uril (CB[6]OH) in water, which undergoes several-fold enhancement of effective emission upon electrostatic interaction with the solid surface of hydroxyapatite nanoparticles (HAp NPs), dispersed in the aqueous media. The corresponding three-component supramolecular assembly disrupts by the intrusion of SP and SPD in the CB[6] portal because of the stronger binding ability with CB[6], resulting in a turn-off fluorescence sensor for SP and SPD with enhanced sensitivity. The assembly–disassembly-based sensing mechanism was thoroughly demonstrated by carrying out isothermal titration calorimetry (ITC), spectroscopic, and microscopic experiments. The sensing system showed low limits of detection (LODs) of 1.4 × 10–8 and 3.6 × 10–8 M for SP and SPD, respectively, which are well below the required range for the early diagnosis of cancer. Besides, a good linear relationship was obtained for both SP and SPD. Nominal interference from various metal ions, anions, common chemicals, amino acids, and other biogenic amines makes this sensing platform suitable for the real-time, low-level measurement of spermine (and spermidine) in human urinary and blood samples.

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Dye-Cucurbit[n]uril Complexes as Sensor Elements for Reliable Pattern Recognition of Biogenic Polyamines

Cited by 31 publications

References 41 publications

Review of advanced sensor devices employing nanoarchitectonics concepts

Review of advanced sensor devices employing nanoarchitectonics concepts

Fullerene Nanoarchitectonics with Shape-Shifting

Solid-Supported Amplification of Aggregation Emission: A Tetraphenylethylene–Cucurbit[6]uril@Hydroxyapatite-Based Supramolecular Sensing Assembly for the Detection of Spermine and Spermidine in Human Urine and Blood

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