Dye-conjugated single-walled carbon nanotubes induce photothermal therapy under the guidance of near-infrared imaging

Liang, Xiaoyuan; Shang, Wenting; Chi, Chongwei; Zeng, Chaoting; Wang, Kun; Fang, Chihua; Chen, Qingshan; Liu, Huiyu; Fan, Ying-Fang; Hui, Hui

doi:10.1016/j.canlet.2016.09.006

Cited by 70 publications

(35 citation statements)

References 35 publications

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“…2 Internal stimuli include pH and redox and high levels of certain enzymes, 3,4 while external stimuli include hyperthermia and magnetic field. [5][6][7][8] In some cases, the internal stimulus combined with the external stimulus will more effectively fine-tune their response to each stimulus and control the drug release more precisely. 9 However, it still remains a great challenge to develop an intelligent controlled-release system which can diagnose the tumor lesion site and realize precise control release at the tumor site.…”

Section: Introductionmentioning

confidence: 99%

Construction and application of a liver cancer-targeting drug delivery system based on core–shell gold nanocages

Ji¹,

Qiu²,

Hou³

et al. 2018

IJN

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BackgroundIn order to achieve drug targeting and controlled release, we have successfully developed a novel drug release system DOX/AuNCs-PM-HA with gold nanocages (AuNCs) as photothermal cores, thermally responsive copolymer P(NIPAM-co-Am) (PM) as the near-infrared (NIR) stimuli gatekeeper and hyaluronic acid as a targeting ligand as well as a capping agent.MethodsCell uptake and cell viability were investigated. In vivo photoacoustic tomography imaging in H22 tumor bearing mice was analyzed for the tumor targeting effect of the nanocomplexes. Antitumor efficacy and the tissue distribution in vivo were investigated.ResultsIn vitro results demonstrated that the DOX/AuNCs-PM-HA had significant anticancer activity against SMMC-7721 cells under NIR irradiation. Furthermore, in vivo photoacoustic tomography imaging of the nanocomplexes in H22 tumor bearing mice could indicate effective tumor targeting. Our studies on antitumor efficacy and the tissue distribution in vivo showed that many DOX/AuNCs-PM-HA nanocomplexes could efficiently accumulate at the tumor site so that they could inhibit the tumor growth effectively with limited side effects. The in vitro and in vivo results confirmed that the tumor-targeting and controlled-release drug system DOX/AuNCs-PM-HA with the combination of chemotherapy and photothermal therapy showed strong anti-tumor effect and would have great potential for future cancer therapy.ConclusionThis tumor targeting DOX/AuNCs-PM-HA nanocomplex responded not only to the external stimuli of NIR, but also the internal stimuli of hyaluronidase, providing the potential for pinpointed and multi-stimuli responsive intracellular drug release.

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Section: Introductionmentioning

confidence: 99%

Construction and application of a liver cancer-targeting drug delivery system based on core–shell gold nanocages

Ji¹,

Qiu²,

Hou³

et al. 2018

IJN

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“…Gollavelli and Ling have taken a simple noncovalent approach to immobilize hydrophobic PS silicon naphthalocyanine bis (trihexylsilyloxide) (SiNc4) onto water dispersible magnetic and fluorescent graphene via π–π stacking, to afford the theranostic nanocarrier . Liang et al prepared Cy5.5‐conjugated single‐walled carbon nanotubes for NIR fluorescence imaging guided PTT against breast tumors by utilizing the absorption of Cy5.5 at 808 nm, which can also increase the PTT efficiency of Cy5.5 . However, carbon materials have not been often used for fluorescence imaging in clinical trials due to their lack of biocompatibility, NIR absorption and fluorescence.…”

Section: Designs For Organic Dye Based Npsmentioning

confidence: 99%

Organic Dye Based Nanoparticles for Cancer Phototheranostics

Cai

Huang

et al. 2018

Small

244

157

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Phototheranostics, which simultaneously combines photodynamic and/or photothermal therapy with deep-tissue diagnostic imaging, is a promising strategy for the diagnosis and treatment of cancers. Organic dyes with the merits of strong near-infrared absorbance, high photo-to-radical and/or photothermal conversion efficiency, great biocompatibility, ready chemical structure fine-tuning capability, and easy metabolism, have been demonstrated as attractive candidates for clinical phototheranostics. These organic dyes can be further designed and fabricated into nanoparticles (NPs) using various strategies. Compared to free molecules, these NPs can be equipped with multiple synergistic functions and show longer lifetime in blood circulation and passive tumor-targeting property via the enhanced permeability and retention effect. In this article, the recent progress of organic dye-based NPs for cancer phototheranostic applications is summarized, which extends the anticancer arsenal and holds promise for clinical uses in the near future.

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“…Organic nanoparticles such as liposomes, solid lipid nanoparticles, dendrimers, polymeric nanoparticles, hydrogels, and polymeric micelles are widely used for drug, gene, or siRNA delivery, cancer therapy, and diagnostics [ 11 ]. Carbon-based nanomaterials include fullerenes [ 12 ], carbon nanotubes [ 13 ], carbon dots [ 14 ], carbon nanofibers [ 15 ], graphene [ 16 ], graphene oxide (GO) [ 17 ], reduced graphene oxide (rGO) [ 18 ], and graphene quantum dots [ 19 ]. Inorganic nanomaterials include metal or metal oxide nanoparticles, including iron oxide (FeO) nanoparticles [ 20 , 21 ], zinc oxide (ZnO) nanoparticles [ 22 , 23 ], silver nanoparticles (AgNPs) [ 24 , 25 ], gold nanoparticles (AuNPs) [ 26 , 27 ], mesoporous silica nanoparticles (SiNPs) [ 28 ], and group II–VI core and core-shell quantum dots (CdSe, CdS, ZnSe, ZnS, etc.)…”

Section: Introductionmentioning

confidence: 99%

Functionalized Graphene Oxide for Chemotherapeutic Drug Delivery and Cancer Treatment: A Promising Material in Nanomedicine

Mondal

2020

IJMS

114

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The usage of nanomaterials for cancer treatment has been a popular research focus over the past decade. Nanomaterials, including polymeric nanomaterials, metal nanoparticles, semiconductor quantum dots, and carbon-based nanomaterials such as graphene oxide (GO), have been used for cancer cell imaging, chemotherapeutic drug targeting, chemotherapy, photothermal therapy, and photodynamic therapy. In this review, we discuss the concept of targeted nanoparticles in cancer therapy and summarize the in vivo biocompatibility of graphene-based nanomaterials. Specifically, we discuss in detail the chemistry and properties of GO and provide a comprehensive review of functionalized GO and GO–metal nanoparticle composites in nanomedicine involving anticancer drug delivery and cancer treatment.

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Dye-conjugated single-walled carbon nanotubes induce photothermal therapy under the guidance of near-infrared imaging

Cited by 70 publications

References 35 publications

Construction and application of a liver cancer-targeting drug delivery system based on core–shell gold nanocages

Construction and application of a liver cancer-targeting drug delivery system based on core–shell gold nanocages

Organic Dye Based Nanoparticles for Cancer Phototheranostics

Functionalized Graphene Oxide for Chemotherapeutic Drug Delivery and Cancer Treatment: A Promising Material in Nanomedicine

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Dye-conjugated single-walled carbon nanotubes induce photothermal therapy under the guidance of near-infrared imaging

Cited by 70 publications

References 35 publications

Construction and application of a liver cancer-targeting drug delivery system based on core&ndash;shell gold nanocages

Construction and application of a liver cancer-targeting drug delivery system based on core&ndash;shell gold nanocages

Organic Dye Based Nanoparticles for Cancer Phototheranostics

Functionalized Graphene Oxide for Chemotherapeutic Drug Delivery and Cancer Treatment: A Promising Material in Nanomedicine

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Construction and application of a liver cancer-targeting drug delivery system based on core–shell gold nanocages

Construction and application of a liver cancer-targeting drug delivery system based on core–shell gold nanocages