Dydrogesterone in the treatment of endometriosis: evidence mapping and meta-analysis

Peng, Chao; Huang, Yan; Zhou, Yang

doi:10.1007/s00404-020-05900-z

Cited by 25 publications

(17 citation statements)

References 24 publications

(77 reference statements)

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“…The results showed significantly better therapeutic effects in OG treated with combined medicine, with statistically shorter abdominal pain relief time and hemostasis time compared with CG. Past studies have also confirmed that TCM combined with dydrogesterone tablets is highly effective in early threatened abortion treatment, which can quickly and effectively stop bleeding, improve clinical symptoms, and increase the levels of progesterone and β -hCG in the body [ 18 ], consistent with our observation. Zishen Yutai pill is a famous prescription for the prevention and treatment of threatened abortion.…”

Section: Discussionsupporting

confidence: 91%

Effects of Dydrogesterone Tablets Combined with Zishen Yutai Pills on Threatened Abortion in Early Pregnancy and Pregnancy Outcomes

Chen¹,

Qiu

Jin³

2022

Computational and Mathematical Methods in Medicine

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Objective. To explore the effect of dydrogesterone tablets combined with Zishen Yutai pills on threatened abortion in early pregnancy and pregnancy outcomes. Methods. This study retrospectively analyzed the clinical data of 100 patients with threatened abortion in early pregnancy who came to the Linhai Second People’s Hospital/Taizhou Municipal Hospital from January 13, 2021, to January 13, 2022. According to different treatment methods, 48 patients treated with progesterone injection were assigned to the control group (CG), while 52 cases with the combined therapy of dydrogesterone tablets and Zishen Yutai pills were assigned to the observation group (OG). The two groups were compared in terms of the following parameters: treatment efficacy, whole blood high shear viscosity, hematocrit (HCT), plasma fibrinogen (FIB) level, spiral artery pulsatility index (PI), uterine spiral artery blood flow resistance index (RI), lumbar and abdominal pain relief time, hemostasis time, estrogen levels, pregnancy outcomes, neonatal adverse outcomes, and incidence of adverse reactions. Results. Compared with CG, the therapeutic effect in OG was observed to be evidently better, and its pain relief time and hemostasis time in the waist and abdomen were markedly shorter. After treatment, the whole blood high shear viscosity, FIB, RI, PI, and estrogen levels of both groups improved statistically compared with those before treatment, with more significant improvements in OG compared with CG. OG was also superior to CG with markedly lower incidence of preterm birth, miscarriage, neonatal adverse outcomes, and adverse reactions and a drastically higher full-term pregnancy rate. Conclusion. Zishen Yutai pill combined with dydrogesterone tablets is of remarkable therapeutic effect in treatment of early threatened abortion, which can significantly improve clinical symptoms and pregnancy outcomes of patients, with a high safety profile, which is worthy of clinical application.

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Section: Discussionsupporting

confidence: 91%

Effects of Dydrogesterone Tablets Combined with Zishen Yutai Pills on Threatened Abortion in Early Pregnancy and Pregnancy Outcomes

Chen¹,

Qiu

Jin³

2022

Computational and Mathematical Methods in Medicine

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“…A non-Cochrane systematic review by Peng et al suggests dydrogesterone (an atypical synthetic progestogen) may result in a higher spontaneous pregnancy rate than no treatment. This review had significant statistical heterogeneity and a high or unclear risk of bias, limiting its ability to influence clinical practice guidelines [7]. This is also reflected in the recent ESHRE guideline [2].…”

Section: Medical Treatment To Enhance Spontaneous Conceptionmentioning

confidence: 99%

The treatment of endometriosis-associated infertility

Spencer

Lazaridis

Grammatis

et al. 2022

Current Opinion in Obstetrics &Amp; Gynecology

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Purpose of reviewTo review the recent evidence around the treatment of infertility in patients with endometriosis.Recent findingsThe management of endometriosis associated infertility remains challenging. There have been an increasing number of prospective observational studies highlighting the role of surgery to enhance assisted conception amongst those with deep rectovaginal endometriosis. Further validation studies confirm the role of the endometriosis fertility index in prediction of reproductive outcomes after surgery, and confirm that it can be employed in counselling patients prior to surgery on their likelihood of spontaneous conception. Further randomized trials are required to establish the role of surgically treating superficial and deep endometriosis and both spontaneous and assisted conception outcomes.SummaryEndometriosis continues to present challenges in counselling patients with regards to their fertility prospects. This article reviews the recent research findings that may assist in the management of patients with endometriosis associated infertility.

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“…Він також знижував ризик рецидивування ендометріозу порівняно з аналогами гонадотропін-рилізинг-гормонів, але підвищував рівень трансаміназ. На сьогодні ще недостатньо даних для зіставлення ефективності дидрогестерону з леупроліду ацетатом, летрозолом або засобами китайської медицини [16].…”

Section: д и с т а н ц і й н е н а в ч а н н яunclassified

The peculiarities of the management of women with endometriosis during pregnancy

Лахно

2021

RHW

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Endometriosis is a significant problem in modern medicine. The prevalence of endometriosis is 10%, it occurs in 38% of women with infertility. For a century, it was believed that pregnancy contributes to the reduction in volume and even the disappearance of foci of endometriosis. Also, the state of «pseudopregnancy» under the influence of combined oral contraceptives was once considered an effective treatment strategy. To date, it is known that decidualization of endometrioid heterotopias not only contributes to their increase in size, but can also provoke bleeding. These changes can mimic ovarian cancer on ultrasonography. Typical complications of endometriosis are enlargement, rupture, or abscess formation.It has been proven that women with endometriosis have an increased relative risk of developing: preeclampsia by 19%; fetal growth retardation by 12%; premature birth by 46%; placenta previa almost threefold; preterm placental abruption by 40%; caesarean section operations by 49%; stillbirth by 27%; postpartum hemorrhage by 5%; spontaneous intra-abdominal bleeding by 24.6 times – only two cases are known in women with endometriosis and no bleeding from the intact peritoneum is known; spontaneous bowel perforation (only 18 cases are known). It has been proven that in pregnant women with endometriosis, the invasion of the extravillous trophoblast into the spiral vessels of the uterus is impaired. However, there is evidence that the endometrioid phenotype is not associated with placental dysfunction and does not increase the risk of developing great obstetric syndromes.Since most of the complications of endometriosis during pregnancy cannot be predicted, any additional interventions are not of use. So, to date, there is no evidence of the need to introduce separate protocols for the management of women with endometriosis during pregnancy. However, there should be an individualization of the approach in each separate case. The given atypical clinical case in a woman with diffuse adenomyosis demonstrates the importance of the problem of predicting various complications of pregnancy and childbirth. Moreover, clinical cases contribute to the continuation of the study of this disease.

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Dydrogesterone in the treatment of endometriosis: evidence mapping and meta-analysis

Cited by 25 publications

References 24 publications

Effects of Dydrogesterone Tablets Combined with Zishen Yutai Pills on Threatened Abortion in Early Pregnancy and Pregnancy Outcomes

Effects of Dydrogesterone Tablets Combined with Zishen Yutai Pills on Threatened Abortion in Early Pregnancy and Pregnancy Outcomes

The treatment of endometriosis-associated infertility

The peculiarities of the management of women with endometriosis during pregnancy

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