Dydrogesterone has no effect on uterine fibroids when used to prevent miscarriage in pregnant women with uterine fibroids

Abstract

Objectives: To analyse the effect of dydrogesterone use during pregnancy on uterine fibroids, pregnancy complications, and pregnancy outcome. Material and methods:In all, 372 pregnant women with uterine fibroids who were treated at the Affiliated Provincial Hospital of Shandong University were included in this study. Thirty-three of these women received dydrogesterone and constituted the treatment group, and the 27 women who were found to have uterine fibroids during the first trimester but did not receive intervention to prevent miscarriage composed the control group. The changes in uterine fibroids before and after pregnancy and the pregnancy complications were recorded; immunohistochemistry was used to detect the expression of progesterone receptor (PR) and proliferation-and apoptosis-related proteins in the uterine fibroid tissue.Results: No significant difference was observed in the change in uterine fibroid volume during pregnancy between the treatment group and the control group (p > 0.05). The percentage of uterine fibroids with red degeneration was lower in the treatment group than in the control group, but the difference was not statistically significant. No significant difference was observed in newborn weight, height, Apgar score, threatened miscarriage, or premature birth, among other characteristics, between the two groups (p > 0.05). Immunohistochemistry showed no significant difference in the expression of PR, cyclinD1, insulin-like growth factor (IGF1), or B-cell lymphoma 2 (Bcl2) between the two groups. Conclusions:The use of dydrogesterone during pregnancy has no significant effect on uterine fibroids, pregnancy progression, or pregnancy outcomes in pregnant patients with uterine fibroids.

Effects of Dydrogesterone Tablets Combined with Zishen Yutai Pills on Threatened Abortion in Early Pregnancy and Pregnancy Outcomes

“…Western medicine mostly uses progesterone supplementation to treat pregnant women with threatened abortion. Dydrogesterone tablets are commonly used clinically to supplement progesterone, which can promote the secretion of chorionic gonadotropin and endogenous progesterone, increase the endocrine activity of placental trophoblast, reduce the level of oxytocin, and antagonize the stimulation of uterus by prostaglandins, thus inhibiting uterine contractions and maintaining pregnancy [ 13 , 14 ]. Some scholars have reported that oral dydrogesterone is effective in the treatment of threatened abortion with a low abortion rate and no congenital malformation [ 15 ].…”

The influence of vaginal progesterone on Uterine Artery Pulsatility Index

“…In addition, its vaginal form is superior to the oral form; although it reaches a faster plasma peak level in oral intake, more constant drug concentrations are observed in vaginal use [16,17]. Progesterone is effectively used for the prevention of threatened miscarriage, preterm labor, preterm birth in women with a short cervix, luteal deficiency, and recurrent miscarriage [18][19][20][21][22][23].…”