Dyclonine hydrochloride as a topical anesthetic in dentistry

Ping, R S; White, J.G.; Spear, Lewis B.

doi:10.1016/s0030-4220(57)80010-3

Cited by 5 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…properties, was initially adopted for endoscopic procedures to reduce pain, nausea, patient movements, and to lubricate the gastroscope [8]. Multiple reports have shown that dyclonine is more effective than tetracaine and lidocaine in providing adequate mucosal anesthesia [9,10].…”

Section: Dyclonine Hydrochloride a Relatively New And Different Chemmentioning

confidence: 99%

Improving safety and effectiveness of awake endotracheal intubation with a novel method: A prospective, double-blind, randomized controlled trial

Han

Guo

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Topical anesthesia is a crucial step in awake endotracheal intubation for providing favorable intubation conditions. The standard of care technique for awake intubation, which consists of oropharyngeal tetracaine spray, can result in inadequate mucosal anesthesia. Therefore, we sought to compare the effectiveness of dyclonine hydrochloride mucilage to the standard of care tetracaine in achieving anesthesia of the upper airways for awake endotracheal intubation. Methods: This randomized, double-blind, prospective study included 60 patients scheduled for either endoscopic submucosal dissection or peroral endoscopic myotomy. Patients were randomly allocated into two groups: patients allocated to novel awake intubation care (Group N-AIC) received a single administration of oral dyclonine hydrochloride mucilage, whereas patients allocated to standard awake intubation care (Group S-AIC) received three oropharyngeal tetracaine sprays before transcricoid tetracaine injection before awake intubation. Feeling of numbness and nausea, as well as intubation conditions after topical anesthesia were assessed. Hemodynamic parameters were recorded throughout the procedure and compared between the two groups. Results: The degree of numbness of the oropharynx mucosa after topical anesthesia did not differ between the two groups, neither did the feeling of nausea during laryngoscopy. The amount of pharyngeal secretions before intubation was less in Group N-AIC. Total intubation time was significantly shorter (3.9s, 95%CI 1.282-6.452, P=0.004) in Group N-AIC. Baseline mean arterial pressure and heart rate were similar between the two groups. Hemodynamic responses to intubation and gastrointestinal endoscopy, especially mean arterial pressure, were significantly less elevated in Group N-AIC. Extubation bucking was significantly less frequent in Group N-AIC (13.3% vs. 76.7%). Patients received in Group N-AIC had a lower rate of post-extubation sore throat compared to Group S-AIC (6.7% vs. 43.3%). No adverse side effects attributable to either tetracaine or dyclonine were observed in this study. Conclusions: In awake endotracheal intubation, novel care using oral dyclonine hydrochloride mucilage can provide more favorable intubation conditions and more stable hemodynamics compared to standard of care practice using oropharyngeal tetracaine spray. Chinese Clinical Trial Registry: ChiCTR1900023151 ( http://www.chictr.org )

show abstract

Section: Dyclonine Hydrochloride a Relatively New And Different Chemmentioning

confidence: 99%

Improving safety and effectiveness of awake endotracheal intubation with a novel method: A prospective, double-blind, randomized controlled trial

Han

Guo

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Dyclonine hydrochloride, a relatively new and different chemical compound with local anesthetic properties, was initially adopted for endoscopic procedures to reduce pain, nausea, patient movements, and to lubricate the gastroscope [ 8 ]. Multiple reports have shown that dyclonine is more effective than tetracaine and lidocaine in providing adequate mucosal anesthesia [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Improving mucosal anesthesia for awake endotracheal intubation with a novel method: a prospective, assessor-blinded, randomized controlled trial

Han

Guo

et al. 2020

BMC Anesthesiol

View full text Add to dashboard Cite

Background Topical anesthesia is a crucial step in awake endotracheal intubation for providing favorable intubation conditions. The standard of care technique for awake intubation at our institution, which consists of oropharyngeal tetracaine spray, can result in inadequate mucosal anesthesia. Therefore, we sought to compare the effectiveness of dyclonine hydrochloride mucilage to the standard of care tetracaine in achieving anesthesia of the upper airways for awake endotracheal intubation. Methods This is a randomized, assessor-blinded, prospective study. From Jun. 1st, 2019 to Aug. 1st, 2019, patients scheduled for either endoscopic submucosal dissection or peroral endoscopic myotomy were enrolled and randomly allocated into two groups after obtaining written informed consent: patients allocated to novel awake intubation care (Group N-AIC) received a single administration of oral dyclonine hydrochloride mucilage, whereas patients allocated to standard awake intubation care (Group S-AIC) received three oropharyngeal tetracaine sprays before transcricoid tetracaine injection before awake intubation. Mean arterial pressure (MAP), which was the primary outcome of this study, as well as heart rate (HR) were recorded throughout the procedure and compared between the two groups. Feeling of numbness, nausea, and intubation conditions after topical anesthesia were also assessed. Results Sixty patients were enrolled and completed the study. Baseline MAP and HR were similar between the two groups. However, hemodynamic responses to intubation and gastrointestinal endoscopy, especially MAP, were significantly less elevated in Group N-AIC. The degree of numbness of the oropharyngeal mucosa after topical anesthesia did not differ between the two groups, neither did the feeling of nausea during laryngoscopy. The amount of pharyngeal secretions before intubation was less in Group N-AIC. Total intubation time was significantly shorter in Group N-AIC when compared to Group S-AIC (18.4 ± 2.86 vs. 22.3 ± 6.47, P < 0.05). Extubation bucking was significantly less frequent in Group N-AIC (13.3% vs. 76.7%). Patients received in Group N-AIC had a lower rate of post-extubation sore throat compared to Group S-AIC (6.7% vs. 43.3%). No adverse side effects attributable to either tetracaine or dyclonine were observed in this study. Conclusions In awake endotracheal intubation, novel care using oral dyclonine hydrochloride mucilage can provide more favorable mucosal anesthesia and better intubation conditions compared to standard of care practice using oropharyngeal tetracaine spray. Trial registration ChiCTR1900023151. Date of registration: May 14th, 2019.

show abstract

“…Clinically the drug has been used in the eye, mouth, bronchi, urethra, and on skin. [2][3][4][5][6][7] Dyclonine is chemically different from any of the local anesthetics in use today.f The compound is a white crystalline powder soluble at a 2% concentration in water.…”

mentioning

confidence: 99%