DWnt4 and DWnt10 Regulate Morphogenesis and Arrangement of Columnar Units via Fz2/PCP Signaling in the Drosophila Brain

Han, Xujun; Wang, Miaoxing; Liu, Chuyan; Trush, Olena; Takayama, Rie; Akiyama, Takaaki; Naito, Toshiki; Tomomizu, Takeshi; Imamura, Kousuke; Sato, Makoto

doi:10.1016/j.celrep.2020.108305

Cited by 13 publications

(18 citation statements)

References 78 publications

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“…The protein Wingless and DWnt4 play a vital role in regulating the PCP pathway. The role of PCP signaling pathway in neuronal migration, neuronal polarization, axonal and dendritic guidance and synaptogenesis is notable [ 72 ]. In the Mediterranean fruit fly, Ceratitis capitata , protein Wnt5b was expressed in flies with full flight ability and regulated cell proliferation in the wings.…”

Section: Discussionmentioning

confidence: 99%

Developmental Transcriptome Analysis of Red-Spotted Apollo Butterfly, Parnassius bremeri

Lee¹,

Jesse²,

Veerappan³

et al. 2022

IJMS

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Parnassius bremeri (P. bremeri), a member of the genus Snow Apollo in the swallowtail family (Papilionidae), is a high alpine butterfly that lives in Russia, Korea, and China. It is an endangered wildlife (Class I) in South Korea and is a globally endangered species. The lack of transcriptomic and genomic resources of P. bremeri significantly hinders the study of its population genetics and conservation. The detailed information of the developmental stage-specific gene expression patterns of P. bremeri is of great demand for its conservation. However, the molecular mechanism underlying the metamorphic development of P. bremeri is still unknown. In the present study, the differentially expressed genes (DEGs) across the metamorphic developmental stages were compared using high-throughput transcriptome sequencing. We identified a total of 72,161 DEGs from eight comparisons. GO enrichment analysis showed that a range of DEGs were responsible for cuticle development and the melanin biosynthetic pathway during larval development. Pathway analysis suggested that the signaling pathways, such as the Wnt signaling pathway, hedgehog signaling pathway and Notch signaling pathway, are regulated during the developmental stages of P. bremeri. Furthermore, sensory receptors were also activated, especially during the larval to adult transition stage. Collectively, the results of this study provide a preliminary foundation and understanding of the molecular mechanism in their transcriptomes for further research on the metamorphic development of P. bremeri.

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Section: Discussionmentioning

confidence: 99%

Developmental Transcriptome Analysis of Red-Spotted Apollo Butterfly, Parnassius bremeri

Lee¹,

Jesse²,

Veerappan³

et al. 2022

IJMS

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“…Dwnt4 and Dwnt10 mutants exhibit relatively mild defects; there are instances of medulla column fusion, as well as defects in medulla column orientation, indicating that they likely act to promote proper placement of neurons within a medulla column. Similarly, mutants in known PCP proteins such as Fz2 and Vang cause similar defects (149). These defects are nonautonomous, indicating that the gradient set up by Wnts acting outside their cells of origin regulates the angle of orientation of a medulla column.…”

Section: Optic Lobe Organization: a Primermentioning

confidence: 94%

Neural specification, targeting, and circuit formation during visual system assembly

Malin

Desplan

2021

Proc. Natl. Acad. Sci. U.S.A.

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Like other sensory systems, the visual system is topographically organized: Its sensory neurons, the photoreceptors, and their targets maintain point-to-point correspondence in physical space, forming a retinotopic map. The iterative wiring of circuits in the visual system conveniently facilitates the study of its development. Over the past few decades, experiments in Drosophila have shed light on the principles that guide the specification and connectivity of visual system neurons. In this review, we describe the main findings unearthed by the study of the Drosophila visual system and compare them with similar events in mammals. We focus on how temporal and spatial patterning generates diverse cell types, how guidance molecules distribute the axons and dendrites of neurons within the correct target regions, how vertebrates and invertebrates generate their retinotopic map, and the molecules and mechanisms required for neuronal migration. We suggest that basic principles used to wire the fly visual system are broadly applicable to other systems and highlight its importance as a model to study nervous system development.

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“…Several scRNA-seq analyses have been performed in the OL, revealing gene expression profiles in a large number of neurons [ 22–26 , 63 ]. In addition, scRNA-seq analysis has been performed focusing on the developing OL, which has led to a better understanding of the temporal patterning of neurogenesis [ 27 , 29 ].…”

Section: Temporal Patterning Following the Proneural Wave In The Larv...mentioning

confidence: 99%

Cutting edge technologies expose the temporal regulation of neurogenesis in the Drosophila nervous system

Sato

Suzuki

2022

Fly

Self Cite

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During the development of the central nervous system (CNS), extremely large numbers of neurons are produced in a regular fashion to form precise neural circuits. During this process, neural progenitor cells produce different neurons over time due to their intrinsic gene regulatory mechanisms as well as extrinsic mechanisms. The Drosophila CNS has played an important role in elucidating the temporal mechanisms that control neurogenesis over time. It has been shown that a series of temporal transcription factors are sequentially expressed in neural progenitor cells and regulate the temporal specification of neurons in the embryonic CNS. Additionally, similar mechanisms are found in the developing optic lobe and central brain in the larval CNS. However, it is difficult to elucidate the function of numerous molecules in many different cell types solely by molecular genetic approaches. Recently, omics analysis using single-cell RNA-seq and other methods has been used to study the Drosophila nervous system on a large scale and is making a significant contribution to the understanding of the temporal mechanisms of neurogenesis. In this article, recent findings on the temporal patterning of neurogenesis and the contributions of cutting-edge technologies will be reviewed.

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DWnt4 and DWnt10 Regulate Morphogenesis and Arrangement of Columnar Units via Fz2/PCP Signaling in the Drosophila Brain

Abstract: Highlights d Neurons assemble to establish a column d Planar cell polarity regulates the orientation of neurons and columns d Wnt ligands globally regulate neuronal orientation and column arrangement

Cited by 13 publications

References 78 publications

Developmental Transcriptome Analysis of Red-Spotted Apollo Butterfly, Parnassius bremeri

Developmental Transcriptome Analysis of Red-Spotted Apollo Butterfly, Parnassius bremeri

Neural specification, targeting, and circuit formation during visual system assembly

Cutting edge technologies expose the temporal regulation of neurogenesis in the Drosophila nervous system

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