“…SVMP-dominated venoms are found in RFS species such as A. prasina (Modahl et al, 2018a), B. portoricensis (Weldon and Mackessy, 2012;Modahl et al, 2018a), D. typus (Kamiguti et al, 2000;Pla et al, 2017b), Hydrodynastes gigas (Hill and Mackessy, 2000), Hypsiglena torquata (McGivern et al, 2014), Phalotris mertensi (Campos et al, 2016), Pseudoboa neuwiedii (Torres-Bonilla et al, 2018), Thamnodynastes strigatus (Ching et al, 2012), Thamnophis sirtalis (Perry et al, 2018), and several Philodryas species (Ching et al, 2006;Peichoto et al, 2012;Urra et al, 2015) (Figure 2B). Potent SVMPs are observed in the venoms of snakes from the genus Philodryas (Assakura et al, 1994;Rocha et al, 2006;Sánchez et al, 2014), and venoms from these species in particular have been commonly reported to induced hemorrhage, myonecrosis and edema (Peichoto et al, 2005;Nery et al, 2014;Sánchez et al, 2014;Oliveira et al, 2017). The proteolytic activity of Philodryas venoms is inhibited by metal chelators (Assakura et al, 1992;Acosta et al, 2003;Peichoto et al, 2005Peichoto et al, , 2012Rocha and Furtado, 2007), suggesting that SVMPs are resulting in these clinical snakebite symptomologies; in some species, serine proteinases may also be involved (Assakura et al, 1994;Peichoto et al, 2005;Ching et al, 2006).…”