Dutch Translation and Validation of the Headache-Specific Locus of Control Scale (HSLC-DV)

Willekens, Marceline C.; Postel, Don; Keesenberg, Martin D. M.; Lindeboom, Robert

doi:10.1155/2018/3046235

Cited by 1 publication

(2 citation statements)

References 21 publications

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“…The headache specific locus of control (HSLC) assesses the individual's perceptions that headache problems and relief are determined by internal factors, healthcare professionals or chance factors [19]. It consists of 33 statements, answered on a 5‐point Likert scale ranging from 1 (strongly disagree) to 5 (strongly agree).…”

Section: Methodsmentioning

confidence: 99%

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Depression and treatment with anti‐calcitonin gene related peptide (CGRP) (ligand or receptor) antibodies for migraine

de Vries Lentsch,

van der Arend,

de Boer

et al. 2023

Euro J of Neurology

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Background and purposeThe aim was to evaluate the effect of anti‐calcitonin gene related peptide (CGRP) (ligand or receptor) antibodies on depressive symptoms in subjects with migraine and to determine whether depressive symptoms predict treatment response.MethodsPatients with migraine treated with erenumab and fremanezumab at the Leiden Headache Centre completed daily E‐headache diaries. A control group was included. Depressive symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS) and the Center for Epidemiological Studies Depression Scale (CES‐D) questionnaires at baseline (T0) and after 3 months (T1). First, the effect of treatment on the reduction in HADS‐D and CES‐D scores was assessed, with reduction in depression scores as the dependent variable and reduction in monthly migraine days (MMD) and treatment with anti‐CGRP medication as independent variables. Second, depression as a predictor of treatment response was investigated, using the absolute reduction in MMD as a dependent variable and age, gender, MMD, active depression, impact, stress and locus of control scores as independent variables.ResultsIn total, n = 108 patients were treated with erenumab, n = 90 with fremanezumab and n = 68 were without active treatment. Treatment with anti‐CGRP medication was positively associated with a reduction in the HADS‐D (β = 1.65, p = 0.01) compared to control, independent of MMD reduction. However, the same effect was not found for the CES‐D (β = 2.15, p = 0.21). Active depression predicted poorer response to erenumab (p = 0.02) but not to fremanezumab (p = 0.09).ConclusionAnti‐CGRP (ligand or receptor) monoclonals lead to improvement of depressive symptoms in individuals with migraine, independent of migraine reduction. Depression may predict treatment response to erenumab but not to fremanezumab.

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Section: Methodsmentioning

confidence: 99%

Section: Headache Specific Locus Of Controlmentioning

confidence: 99%