Düşük serum meteorin benzeri/subfatin seviyesi, obezite ve insülin direnci ile ilişkilidir

Abstract

Introduction: Meteorin-like (Metrnl), also known as subfatin is a newly discovered adipokine of adipocyte origin that may play a role in obesity and insulin resistance. The current study aimed to investigate the association between subfatin and biochemical values, demographic characteristics, and insulin resistance in obese patients and healthy controls.Methods: This cross-sectional study included 59 obese patients with sex and age-matched group of 41 healthy controls. An enzyme-linked immunosorbent assay (ELISA) was used to measure the serum levels of Subfatin (Metrnl), and the correlations of Metrnl level with anthropometric parameters, HOMA index, and biochemical measurements were assessed.Results: The levels of BMI (p<0.001), insulin (p=0.002), and HOMA-IR score (p<0.001) were significantly higher in obese patients than controls. The serum levels of Subfatin were found to be lower in obese patients (1.85 [1.35–5.51] ng/ml) compared to the healthy controls (21.82 [12.61–27.76] ng/ml) (p<0.001). Subfatin had a significantly negative relationship with age (r =-0.250, p=0.012), weight (r =-0.373, p=0.001), BMI (r =-0.492, p=0.001), HbA1c (r =-0.209, p=0.037), LDL (r =-0.264, p=0.008), HOMA-IR (r =-0.223, p=0.026), and glucose (r =-0.376, p<0.001). There was a significantly positive correlation between subfatin and height (r=0.321, p=0.001).Conclusion: These results show that levels of subfatin were decreased in obese patients. There is a relationship between circulating amounts of subfatin hormone and age, weight, height, LDL-cholesterol, glucose, hbA1c, and HOMA-IR. Subfatin might be a new biomarker of obesity and insulin resistance.Keywords: Meteorin-like/subfatin, adiposity, insulin resistance, adipokines, biomarkers, diabetes mellitus type 2

A review on the role of novel adipokine Isthmin-1 and Subfatin in human type 2 diabetes mellitus

“…Low subfatin level may be linked to deteriorating glucose tolerance. Insulin resistance and Insulin sensitivity may be impacted by changes in subfatin expression, particularly when such changes are brought on by increasing body adiposity from obesity [50]. The information on the subfatin levels in diabetes individuals' circulation is concerning.…”