Dust mites living in human lungs – the cause of asthma?

Woerden, H. van

doi:10.1016/j.mehy.2004.02.047

Cited by 12 publications

(4 citation statements)

References 14 publications

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“…2 ), which reflects the diverse HDM amount and environmental conditions that people are exposed to daily basis. Although it is experimentally challenging to reproduce these variable exposure conditions to reliably predict the quantity of HDM or associated components that end up in the airway, evidence shows that HDM is found in the sputum and even deep lungs [ 52 ], which supports our hypothesis that HDM directly interacts and degrades BPIFA1. We have also demonstrated that the main component responsible for HDM-mediated BPIFA1 degradation is Der p1, a cysteine protease ( Fig.…”

Section: Discussionsupporting

confidence: 65%

Degradation of bacterial permeability family member A1 (BPIFA1) by house dust mite (HDM) cysteine protease Der p 1 abrogates immune modulator function

Zhang

Trower

2020

International Journal of Biological Macromolecules

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Bacterial permeability family member A1 (BPIFA1) is one of the most abundant proteins present in normal airway surface liquid (ASL). It is known to be diminished in asthmatic patients' sputum, which causes airway hyperresponsiveness (AHR). What is currently unclear is how environmental factors, such as allergens' impact on BPIFA1's abundance and functions in the context of allergic asthma. House dust mite (HDM) is a predominant domestic source of aeroallergens. The group of proteases found in HDM is thought to cleave multiple cellular protective mechanisms, and therefore foster the development of allergic asthma. Here, we show that BPIFA1 is cleaved by HDM proteases in a time-, dose-, and temperature-dependent manner. We have also shown the main component in HDM that is responsible for BPIFA1's degradation is Der p1. Fragmented BPIFA1 failed to bind E . coli lipopolysaccharide (LPS), and hence elevated TNFα and IL-6 secretion in human whole blood. BPIFA1 degradation is also observed in vivo in bronchoalveolar fluid (BALF) of mice which are intranasally instilled with HDM. These data suggest that proteases associated with environmental allergens such as HDM cleave BPIFA1 and therefore impair its immune modulator function.

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Section: Discussionsupporting

confidence: 65%

Degradation of bacterial permeability family member A1 (BPIFA1) by house dust mite (HDM) cysteine protease Der p 1 abrogates immune modulator function

Zhang

Trower

2020

International Journal of Biological Macromolecules

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“…It is also interesting to note that mites, eggs or larval forms were detected in human lungs, supporting the high local HDM allergen concentration hypothesis in the airways [95]…”

Section: Importance Of the Allergen Dose On The Relevance Of Hdm-indumentioning

confidence: 77%

The Role of the House Dust Mite-Induced Innate Immunity in Development of Allergic Response

Jacquet

2010

Int Arch Allergy Immunol

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House dust mite (HDM) represents one of the most common sources of aeroallergens worldwide and more than 50% of allergic patients are sensitized to these allergenic molecules. HDM allergy research in the past has been mainly focused on adaptive, mite allergen-dependent immune responses. In recent years it has become clear that, although the allergen-specific CD4+ Th2 cellsorchestrate HDM allergic response,the innate immune system also plays a critical role in HDM-induced allergy pathogenesis. This review will summarize insights into diverse determinants that contribute to the HDM allergenicity through the activation of innate immunity. In addition to the capacity of mite allergens to directly activate mainly skin keratinocytes and airway epithelial cells, innate pattern recognition receptor ligands derived from HDM carriers are also involved in the development of allergic response by HDM.

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“…Nevertheless, Tarsonemus mites have been found in fresh sputum of people with asthma and respiratory irritation (Carter et al., 1944; Li and Li, 1990). It possibly hints that these mites can live in human lungs and cause asthma (van Woerden, 2004). Furthermore, it is also accepted that ‘any mite species present in the human environment in large enough quantities (i.e.…”

Section: Discussionmentioning

confidence: 99%

Influence of environmental characteristics and climatic factors on mites in the dust of air-conditioner filters

Liu

Ran

et al. 2009

Indoor Air

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Mites present in the dust of air-conditioner filters are potential indoor threat to asthma and allergy sufferers. In this study, we find that the storage mite Tarsonemus granarius is the predominant species of mites in the dust of air-conditioner filters (MACF). Thus, the possible clinical importance of T. granarius should cause more our attentions in the future. The abundance and distribution of MACF are also found significantly varied in different climatic regions of China. When we try to assess the possible risk of MACF, more attentions should be focused on subtropical region than temperate region. The influence analysis of environmental characteristics on the prevalence of MACF will shed light on the establishment of mite control strategy and the design of mite defense air-conditioner.

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Dust mites living in human lungs – the cause of asthma?

Cited by 12 publications

References 14 publications

Degradation of bacterial permeability family member A1 (BPIFA1) by house dust mite (HDM) cysteine protease Der p 1 abrogates immune modulator function

Degradation of bacterial permeability family member A1 (BPIFA1) by house dust mite (HDM) cysteine protease Der p 1 abrogates immune modulator function

The Role of the House Dust Mite-Induced Innate Immunity in Development of Allergic Response

Influence of environmental characteristics and climatic factors on mites in the dust of air-conditioner filters

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