Explosion isolation flap valves are one of the most used explosion protection systems in process industries; research is essential to improve them and to minimise both human and material losses when dust explosions take place. In this regard, there is little knowledge on the effect of bends in the functionality of these protective systems; hence, the main aim of this work is to bridge this gap. Large-scale dust explosions were performed, using three different types of dust: metal dust and two types of organic dust. In order to analyse the effect of bends in the functionality of these protective systems, results using a straight duct and one with bends were compared for each dust tested. In addition, the influence of the bend radius on aluminium dust explosions was also evaluated. The results indicated that the effect of bends depended on the explosive characteristics of the dust. However, for aluminium and maize starch dusts, bends led to higher pressures and flame velocities. Relevant information is provided to help decision-making when designing these valves. Moreover, such data can be used for consideration in the discussions held by the task force entrusted with developing the standard used to assess their functionality.