Abstract:Staphylococcus aureus (S. aureus) is a major human pathogen that causes apoptosis of immune cells during infections. The rate of apoptosis influences the severity and outcome of the disease, which can be fatal for infections including sepsis and septicemia. Dual specificity phosphatase-1 (DUSP1) is a negative regulator of MAPK signaling pathways in the host innate immune response, but its role in S. aureus-induced apoptosis remains unexplored. We used western blotting and immunofluorescence assays to show that… Show more
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