Duration till diagnosis and clinical profile of Sjögren’s syndrome: Data from real clinical practice in a single-center cohort

Kuryata, Olexandr; Lysunets, T.; Караванська, І. Л.; Semenov, Viktor

doi:10.1016/j.ejr.2019.05.003

Cited by 6 publications

(2 citation statements)

References 25 publications

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“… 20 One Ukrainian study evaluated diagnostic delay in 24 patients with pSS or secondary Sjögren’s syndrome and reported a significant delay of 8.5 (range 2.8-17) years, with pSS presenting at an older age. 21 The diagnostic delay in our cohort was variable, reaching 11 years in one patient; however, the mean delay was shorter than what has been reported, barely exceeding 2 years. This could be explained by 2 factors.…”

Section: Discussioncontrasting

confidence: 55%

Disease phenotype and diagnostic delay in Saudi patients with primary Sjögren’s syndrome

Omair

Alqahtani

Alhamad

et al. 2021

SMJ

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Objectives: To describe primary Sjögren’s syndrome (pSS) cohort in Saudi Arabiain view in of clinical/serological/histopathological phentotype, and, diagnostic delay. Methods: A cross-sectional study conducted between October 2018 and May 2019. Diagnostic delay was calculated from symptoms onset to clinical diagnosis. The European League Against Rheumatism (EULAR) Sjögren’s Syndrome Disease Activity Index (ESSDAI) and EULAR Sjogren’s Syndrome Patient Reported Index (ESSPRI) were calculated. Results: Forty-one patients were included in the study. There were predominantly females (78%) with a mean (±SD) age of 58.76±12.7 and disease duration of 4.6±2.28 years. The mean diagnostic delay was 2.2±2.4 (range 1-11) years. Minor salivary gland biopsy was performed on 38 (92.7%) patients with a mean focus score of 2.3± 1.2 points. Interstitial lung disease and arthritis were the most common extra-glandular manifestations (EGM) affecting 27 (65.9%) patients for both. The mean ESSDAI was 9.95±7.73 and ESSPRI was 5.17±2.4. Conclusion: Saudi primary Sjogren’s syndrome patients have a high prevalence of EGM predominantly arthritis and ILD. The diagnostic delay is variable in our cohort.

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Section: Discussioncontrasting

confidence: 55%

Disease phenotype and diagnostic delay in Saudi patients with primary Sjögren’s syndrome

Omair

Alqahtani

Alhamad

et al. 2021

SMJ

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“…Currently, the diagnosis of pSjD is done making use of the 2016 ACR-EULAR classification criteria as a guideline (1). Unfortunately, clinical representation differs greatly between patients, which often leads to difficulties and diagnostic delays (2,3). Furthermore, for sSjD no established classification exist (4).…”

Section: Introductionmentioning

confidence: 99%

The diagnostic power of salivary electrolytes for Sjögren's disease: a systematic literature review and meta-analysis

van Santen,

Assy,

Bikker

et al. 2023

Clinical and Experimental Rheumatology

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Objective. To perform a systematic review and meta-analysis to determine the power of salivary electrolytes for the diagnosis of Sjögren's disease (SjD). Methods. A literature search was conducted (last search March 2023) using PubMed and Web of Science and completed with a manual search. Articles were screened for reports of human salivary ion concentrations, comparing SjD patients with healthy controls and/or sicca patients. Articles not using the SjD classification criteria or performing the classification as part of the experimental design were excluded. Forest plots were used to present the meta-analyses results for each ion, distinguishing between salivary type (unstimulated and stimulated whole saliva, submandibular/sublingual and parotid saliva). Results. A total of 21 out of 722 articles were eligible for inclusion. For SjD patients a significant increase in salivary ion concentration was observed for sodium, chloride and calcium when comparing to healthy controls. Significant differences between SjD and sicca patients were noted for sodium, chloride, phosphate, calcium, phosphate, nitrite and nitrate. Stimulated whole saliva showed larger variability in results between studies in comparison to other types of saliva (unstimulated whole saliva, submandibular/sublingual saliva and parotid saliva). Conclusion. Despite differences in saliva type, salivary ion levels could be utilised for the screening for SjD. Making use of chloride in combination with sodium would be most promising for distinguishing SjD patients from healthy controls and adding phosphate to potentially make a distinguishment with sicca patients. Unstimulated whole saliva should be the first choice when testing salivary ion concentrations.

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Hematologic parameters and disease activity in patients with primary Sjögren's syndrome

Moghaddam

Saremi

Atabati

et al. 2022

The Egyptian Rheumatologist

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Duration till diagnosis and clinical profile of Sjögren’s syndrome: Data from real clinical practice in a single-center cohort

Cited by 6 publications

References 25 publications

Disease phenotype and diagnostic delay in Saudi patients with primary Sjögren’s syndrome

Disease phenotype and diagnostic delay in Saudi patients with primary Sjögren’s syndrome

The diagnostic power of salivary electrolytes for Sjögren's disease: a systematic literature review and meta-analysis

Hematologic parameters and disease activity in patients with primary Sjögren's syndrome

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