Duration of untreated psychosis and cognitive functioning

Rapp, Charlotte; Studerus, Erich; Bugra, Hilal; Aston, Jacqueline; Tamagni, Corinne; Walter, Anna; Pflueger, Marlon O.; Borgwardt, Stefan; Riecher-Rössler, Anita

doi:10.1016/j.schres.2012.12.016

Cited by 28 publications

(15 citation statements)

References 36 publications

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“…Like a majority of studies from AOS (Rapp et al., ; Rund, ; Rund et al., ), we found no significant influence of DUP on long‐term cognition in EOS; thus, there were no signs of neurotoxicity at least in the timeframe measured. In adolescence, the brain matures extensively, and one could assume that a longer DUP would have a more severe impact on cognition in this time period.…”

Section: Discussionsupporting

confidence: 78%

Do clinical characteristics predict the cognitive course in early‐onset schizophrenia‐spectrum disorders?

Teigset

Mohn

Brunborg

et al. 2018

Child Psychology Psychiatry

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Though at different levels, the EOS group and the controls had a similar cognitive course over 2 years. Some baseline characteristics (psychotic symptoms, DUP, remission, and hospitalization) had no influence on cognition within the first 2 years of illness. In contrast, general symptoms and a history of suicide attempts at baseline were more potent risk factors of the cognitive course than the psychotic-specific symptoms, and should, therefore, be subject to specific attention in the evaluation and treatment of patients with early-onset psychosis.

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Section: Discussionsupporting

confidence: 78%

Do clinical characteristics predict the cognitive course in early‐onset schizophrenia‐spectrum disorders?

Teigset

Mohn

Brunborg

et al. 2018

Child Psychology Psychiatry

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“…The study of Rapp et al (2013) included 60 first-episode psychosis patients and an at-risk mental state with later transition to psychosis (ARMS-T) sample of 24 subjects. Associations between DUP and neurocognitive performance were tested by three different operationalizations of cognition, among them a deterioration index (DI).…”

Section: Resultsmentioning

confidence: 99%

Does active psychosis cause neurobiological pathology? A critical review of the neurotoxicity hypothesis

Rund

2013

Psychol. Med.

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“…Attention was assessed with the Continuous Performance Test (CPT-OX; Rosvold et al, 1956), which in a stricter sense measures vigilance. For a more detailed description of the above mentioned tests, see Rapp et al (2013) or Pflueger et al (2007).…”

Section: Neurocognitive Assessmentmentioning

confidence: 99%

The relationship between negative symptoms and cognitive functioning in patients at clinical high risk for psychosis

Leanza

Egloff

Studerus

et al. 2018

Psychiatry Research

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Negative symptoms and neurocognitive performance have been reported to be negatively associated in patients with emerging psychosis. However, most previous studies focused on patients with frank psychosis and did not differentiate between subdomains of negative symptoms. Hence, we aimed to elucidate the specific relationship between negative symptoms and cognitive functioning in patients at clinical high risk (CHR) for psychosis. Data from 154 CHR patients collected within the prospective Früherkennung von Psychosen (FePsy) study were analyzed. Negative symptoms were assessed with the Scale for the Assessment of Negative Symptoms (SANS) and cognitive functioning with an extensive neuropsychological test battery. Regression analyses revealed significant negative associations between negative symptoms and cognitive functioning, particularly in the domains of nonverbal intelligence and verbal fluency. When analyzing each negative symptom domain separately, alogia and asociality/anhedonia were significantly negatively associated with nonverbal intelligence and alogia additionally with verbal fluency. Overall, our results in CHR patients are similar to those reported in patients with frank psychosis. The strong negative association between verbal fluency and negative symptoms may be indicative of an overlap between these constructs. Verbal fluency might have a strong influence on the clinical impression of negative symptoms (particularly alogia) and vice versa.

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Duration of untreated psychosis and cognitive functioning

Cited by 28 publications

References 36 publications

Do clinical characteristics predict the cognitive course in early‐onset schizophrenia‐spectrum disorders?

Do clinical characteristics predict the cognitive course in early‐onset schizophrenia‐spectrum disorders?

Does active psychosis cause neurobiological pathology? A critical review of the neurotoxicity hypothesis

The relationship between negative symptoms and cognitive functioning in patients at clinical high risk for psychosis

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