Duration of the preemptive analgesic effects of low‐ and high‐frequency transcutaneous electrical nerve stimulation in rats with acute inflammatory pain
Hideshi Ikemoto,
Naoki Adachi,
Takayuki Okumo
et al.
Abstract:Transcutaneous electrical nerve stimulation (TENS) activates various pathways to induce antinociceptive effects, based on the frequencies used. This study evaluates the preemptive analgesic effects and their duration of low‐ (LT: 4 Hz) and high‐frequency TENS (HT: 100 Hz) using a rat model of acute inflammatory pain. Acute inflammation was induced by injecting 1% formalin into the hind paws of rats. LT or HT was applied for 30 min before formalin injection. Pain‐related behaviors, such as licking, flinching, a… Show more
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