Duration of the latency period in preterm premature rupture of the membranes. Maternal and neonatal consequences of expectant management

Dale, Per Olav; Tanbo, Tom; Bendvold, E.; Moe, Narve

doi:10.1016/0028-2243(89)90010-5

Cited by 39 publications

(20 citation statements)

References 5 publications

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“…When compared to the literature, we see that the study conducted by Dale et al [28]. on 111 PPROM pregnant women between 20-34 weeks found the median value of the latent period to be 7 (0-109) days In our study, we thought that the mean was increased because the post-treatment latent period of two PROM patients were 112 and 80 days after the development of PROM.…”

Section: Discussionsupporting

confidence: 46%

Use of vaginal creatinine levels in detecting premature rupture of membranes

Kuruoğlu¹,

Bıldırcın²,

Karli³

et al. 2019

Journal of Surgery and Medicine

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How to cite / Atıf için: Kuruoğlu YS, Bıldırcın FD, Karlı P, Özdemir AZ. Use of vaginal creatinine levels in detecting premature rupture of membranes.This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND 4.0) where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. AbstractAim: Misdiagnosis is frequent in premature rupture of membranes (PROM) patients. The most accurate diagnosis of PROM requires reliable laboratory tests. Due to the lack of a gold-standard diagnostic method, many methods have been proposed in this regard. The aim of this study is to determine an easy diagnostic method in early membrane rupture and to determine the usability, reliability and cut-off values of vaginal creatinine measurements in the detection of PROM compared to vaginal placental alpha microglobulin-1 (PAMG-1) test. Methods: We designed a cross-sectional study. A total of 63 patients admitted to the Obstetrics and Gynecology Clinic of Samsun Ondokuz Mayıs University with suspected PROM between 15 November 2012 and 15 June 2013 were included in this study. Following anamnesis, all patients were vaginally subjected to PAMG-1 (AmniSure® ROM) test with sterile speculum and injected with 5 cc of saline into the vagina, and then, a 3 cc sample was retrieved with the same injector and put into a biochemistry tube. Immediately thereafter, the material was sent to the biochemistry laboratory, centrifuged and stored at -70 0 C until all samples were studied. The patients were classified as PROM and non-PROM based on the positive or negative result of PAMG-1 test. Following this classification, the patients were also grouped as PROM and non-PROM according to their vaginal creatinine values. Results: The mean maternal age of our patients was 26.3 years in the PROM group and 28.8 years in the non-PROM group. The mean gestational weeks were 30.8 weeks in the PROM patients and 32.5 weeks in the non-PROM patients. Of 20 patients subjected to PAMG-1 test for PROM diagnosis, 17 were PAMG-1 and creatinine positive while 3 were PAMG-1 negative and creatinine positive. Of 43 patients subjected to PAMG-1 test, 42 were PAMG-1 negative while 1 was PAMG-1 positive and creatinine negative. Accordingly, vaginal creatinine was found to have 94.4% sensitivity, 93.3% specificity, 85% positive predictive value, and 97.7% negative predictive value in PROM diagnosis. The mean creatinine values in the PROM and non-PROM groups were 0.39 (0.31) mg/dl and 0.04 (0.10) mg/dl, respectively (P=0.05). Conclusion: Creatinine assessment in vaginal flushing fluid can be a cheaper, faster, easily accessible and highly accurate test with 94.4% sensitivity and 93.3% specificity in PROM diagnosis. Öz Amaç: Erken membran rüptürü (EMR) bulunan hastaların teşhisinde yanılgılar sık görülebilmektedir. EMR tanısını en doğru şekilde koymak için güvenilir laboratuvar...

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Section: Discussionsupporting

confidence: 46%

Use of vaginal creatinine levels in detecting premature rupture of membranes

Kuruoğlu¹,

Bıldırcın²,

Karli³

et al. 2019

Journal of Surgery and Medicine

View full text Add to dashboard Cite

show abstract

“…The median latency after PPROM is 7 days and tends to shorten as the gestational age at PPROM advances …”

Section: Background and Scopementioning

confidence: 99%

“…2The median latency after PPROM is 7 days and tends to shorten as the gestational age at PPROM advances. 3,4 This guideline comprises recommendations relating to the diagnosis, assessment, care and timing of birth of women presenting with suspected PPROM from 24 +0 to 36 +6 weeks of gestation. It also addresses care in a subsequent pregnancy.…”

mentioning

confidence: 99%

Care of Women Presenting with Suspected Preterm Prelabour Rupture of Membranes from 24⁺⁰ Weeks of Gestation

Thomson¹,

Gynaecologists²

2019

BJOG

121

135

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“…Previous studies have noted that latency with PPROM can last for weeks, and that PPROM at earlier gestations appear to have longer latency to delivery. 1,2 However, little data exist to describe latency at specific gestational ages. We have taken the opportunity to utilize a large and well described cohort of patients with PPROM to describe latency of PPROM occurring between 24 and 31 weeks’ gestation.…”

Section: Commentmentioning

confidence: 99%

“…Length of latency until delivery appears to be inversely related to the gestational age at which PPROM occurs, but little data exist to describe this relationship against the background of prophylactic antibiotics. 1,2 Our research network conducted a trial evaluating the use of magnesium sulfate to prevent cerebral palsy in patients at high risk of early preterm delivery. 3 Because the majority of women entered into this large randomized trial had PPROM and were managed expectantly, it afforded the opportunity to estimate gestational age specific measures of latency in patients experiencing PPROM between 24-31 weeks’ gestation and who routinely received antibiotics for pregnancy prolongation.…”

Section: Introductionmentioning

confidence: 99%

Length of Latency with Preterm Premature Rupture of Membranes before 32 Weeks' Gestation

Peaceman¹,

Lai

Rouse

et al. 2014

Amer J Perinatol

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Objective To describe latency for patients with preterm premature membrane rupture (PPROM) between 24 0/7 and 31 6/7 weeks’ gestation. Study Design Secondary analysis of data collected prospectively in a multicenter clinical trial of magnesium sulfate for cerebral palsy prevention. Women with PPROM and fewer than 6 contractions per hour at enrollment who were candidates for expectant management (n=1377) were included in this analysis. Length of latency was calculated in days by subtracting the time of delivery from the time of membrane rupture. Results At each week of gestation, median latency between 24-28 weeks was similar at approximately 9 days, but was significantly shorter with PPROM at 29, 30, and 31 weeks (p<0.001). In addition, the percentage of patients remaining undelivered at 7 days and 14 days was similar for PPROM between 24-28 weeks, but decreased significantly after that. For each gestational age, the proportion of patients remaining pregnant declined in a fashion similar to exponential pattern. Conclusion Median latency after PPROM is similar from 24-28 weeks’ gestation, but shortens with PPROM at and after 29 weeks.

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Duration of the latency period in preterm premature rupture of the membranes. Maternal and neonatal consequences of expectant management

Cited by 39 publications

References 5 publications

Use of vaginal creatinine levels in detecting premature rupture of membranes

Use of vaginal creatinine levels in detecting premature rupture of membranes

Care of Women Presenting with Suspected Preterm Prelabour Rupture of Membranes from 24⁺⁰ Weeks of Gestation

Length of Latency with Preterm Premature Rupture of Membranes before 32 Weeks' Gestation

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Duration of the latency period in preterm premature rupture of the membranes. Maternal and neonatal consequences of expectant management

Cited by 39 publications

References 5 publications

Use of vaginal creatinine levels in detecting premature rupture of membranes

Use of vaginal creatinine levels in detecting premature rupture of membranes

Care of Women Presenting with Suspected Preterm Prelabour Rupture of Membranes from 24+0 Weeks of Gestation

Length of Latency with Preterm Premature Rupture of Membranes before 32 Weeks' Gestation

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Care of Women Presenting with Suspected Preterm Prelabour Rupture of Membranes from 24⁺⁰ Weeks of Gestation