Duration of ruptured membranes and vertical transmission of HIV-1: a meta-analysis from 15 prospective cohort studies

Bulterys, M. B.; Fowler, Mary Glenn; Hanson, I. Celine; LeMay, Mireille; Mayaux, Marie Jeanne; Mofenson, Lynne; Newell, Marie‐Louise; Read, Jennifer S.; Rother, Christian; Simpson, B. Joyce; Dyke, Russell B. Van; Harris, D.R.; Peavy, Hannah; Easley, Kirk A.; Khammy, A.; Nugent, Robert P.; Mitchell, Robert J.; Owen, William F.; Dyke, Russell Van; Widmayer, Susan M.; Bardeguez, Arlene; Hanson, Celine; Wiznia, Andrew; Luzuriaga, Katherine; Viscarello, Richard R.; Ho, Dsy; Koup, Richard A.; Chen, I.; Krogstad, Paul; Mullins, James I.; Wolinsky, Steven M.; Korber, Bette T.; Walker, B.F.; A., Ammann Roland; Clapp, Sheila; McDonald, D.; Lapointe, Nancy Allen; Boucher, Marc; Fauvel, M.; Hankins, Catherine; Samson, Johanne; Peckham, Catherine; Thorne, C; Giaquinto, Carlo; Ruga, Ezia; Rossi, Anita De; Truscia, D.; Grosch-Wörner, I.; Schäfer, Axel; Mok, Janice; Johnstone, Frank D.; Jiminez, Juan; Alba, C. de; Rodrı́guez, Marı́a C.; Bates, I.; Joseé, I. de; Hawkins, Federico; Zapico, R.; Peña, José M.; Garcia, J. Gonzalez; Lopez, J. R. Arribas; Asensi-Botet, F.; Otero, M. C.; Peérez-Tamarit, D.; Moya, A.; Galbis, M; Scherpbier, H. J.; Boer, Kees; Bohlin, Ann‐Britt; Lindgrén, Susanne; Anzén, Bo; Belfrage, Erik; Lidin-Jansson, G.; Levy, Jack S.; Barlow, Patricia; Hainaut, Marc; Peltier, Alexandre; Ferrazin, Antonio; Maria, Andrea De; Gotta, Cristina; Viñolas, M. Domenech; Payà, Antoni; Loépez-Vilchez, M. A.; Coll, O.; Fortuny, Clàudia; Boguña, J.; Casellas, M.; Canet, Yolanda; Pardi, Giorgio; Ravizza, Marina; Semprini, E.; Castagna, C.; Fiore, Simona; Guerra, Brunella; Lanari, Marcello; Bianchi, Soledad; Bovicelli, Luciano; Prati, E.; Zanelli, Santina; Duse, Marzia; Soresina, Annarosa; Scaravelli, Giulia; Stegagno, M; Santis, Marco De; Viganò, Alessandra; Spinillo, Arsenio; Probizer, F. Ravagni; Bucceri, A.; Rancilio, L.; Taylor, GP; Lyall, Hermione; Penn, Zoe J.; Blott, Maggie; Valerius, NH; Martinelli, Pasquale; Buffolano, Wilma; Tibaldi, Cecilia; Ziarati, N.; Semprini, A; Torre, Marina; Parazzini, Fabio; Dallacasa, P; Bianchi, Umberto; Pachı́, A.; Mancuso, Stefano; Villa, Paola; Conti, M.; Principi, Niccolò; Muggiasca, Maria Luisa; Marchisio, Paola; Zara, C; Ravagni, F.; Vignali, Mario; Rossi, Gabriele; Selvaggi, Luigi; Greco, Pantaleo; Vimercati, Antonella; Massi, G. b.; Innocenti, Tiziano; Fiscella, Antonio; Sansone, Matilde; Benedetto, Chiara; Tadrist, B.; Thevenieau, D.; Gondry, J.; Paulard, B.; Alisy, C.; Bron, Dominique; Tordjeman, N; Mamou, J.; Rozan, M.; Colombani, Dominique; Pincemaille, O; Salvetti, Andrea; Chabanier, Catherine; Hernandoréna, X.; Leroy, Julien; Schaal, J.-P.; Balde, P.; Faucher, Philippe; Lachassinne, E.; Benoit, Stephen R.; Douard, Danielle; Hocké, C.; Barjot, P.; Brouard, J.; Delattre, P.; Stien, L.; Audibert, François; Labrune, Philippe; Vial, Michael; Mazy, Fabienne; Sitbon, D.; Crenn‐Hébert, Catherine; Floch‐Tudal, Corinne; Akakpo, R.; Daveau, C.; LeBlanc, Alain; Cesbron, Paul; Duval-Arnould, Marc; C, Huraux-Rendu; Lemerle, S.; Touboul, C.; Guérin, Mathilde; Maingueneau, C; Reynaud, I; Rousseau, Thierry; Ercoil, V.; Lanza, Marina; Denavit, M.; Garnier, J.M.; Lahsinat, K.; Pia, Patrick; Allouche, C.; Nardou, M.; Grall, Franck; May, Adrien; Dallot, Marie-Christelle; Lhuillier, Pierre; Cecile, W.; Mezin, R.; Bech, Anneke; Lobut, J.; Algava, Gilbert; Dermesay, A. Chalvon; Busuttil, Rita A.; Jacquemot, M.-C.; Bader-Meunier, B.; Fridman, Sebastián; Codaccioni, X; Maxingue, F.; Thomas, D.; J, Alain; Lumley, L. De; Tabaste, J L; Salin, P. Bailly; Seaume, Hervé; Guichard, A.; Kebaïll, K.; Roussouly, C.; Botto, Carlos; Lanete, A. De; Wipff, P.; Cravello, L.; Boisse, P. De; Leclaire, M; Michel, Ghylene Bourdat; Crumiere, C.; Lefevre, V.; Lorier, Bertrand Le; Pauly, I.; Robichez, B.; Séguy, D.; Delhinger, M.; Rideau, F.; Talon, Philippe; Bénos, P.; Huret, C.; Nicolás, José M.; Heller‐Roussin, Brigitte; Saint‐Leger, S.; Delaporte, Matthieu; Hubert, C.; Sarcus, B. De; Karoubi, Philippe; Méchinaud, Françoise; Bertcrottiere, D.; Bongain, A.; Monpoux, Fabrice; Gennes, Christiane De; Devianne, François; Nisand, I.; Rousset, M.; Mouchnino, G; Mur, Antonio; Munzer, Martine; Quereux, C.; Brossard, V.; Clavier, Brigitte; Allemon, M. C.; Rotten, D.; Stéphan, Jean-Louis; Varlet, Marie-Noëlle; Guyot, Bernard; Narcy, P; Bardinet, F.; Caunes, F de; Jeny, R.; Robin, Marie; Boulley, A. Raison; Savey, Léa; Berrébi, Alain; Tricoire, J; Borderon, J.C.; Fignon, A; Guillot, Florian H.; Maria, B. Menezes Ana; Broyard, A; Chitrit, Yvon; Firtion, Ghislaine; Mandelbrot, Laurent; Pillet, Marie-Christine Lafay; Parat, Sophie; Boissinot, Christine; Garec, N.; Lévine, Martine; Ottenwalter, Annick; Schaller, F.; Vilmer, E; Courpotin, C; Brunner, C; Ciraru-Vigneron, N; Hatem-Gantzer, G.; Fritel, Xavier; Wallet, A.; Bouillé, Jeanne Goupil de; Milliez, Jacques; Mrejen, D. Bensaid; Dermer, E.; Noseda, G; Bardou, D.; Cressaty, J.; Francoual, C; Moncomble, C. Carlus; Cohen, Helen S.; Blanche, Stéphane; Bastion, H.; Bénifla, Jean-Louis; Benkhatar, F.; Berkane, Narimane; Herveé, F.; Ronzier, M.; Martino, Maurizio de; Tovo, Pier-Angelo; Galli, Luisa; Gabiano, Clara; Ferraris, G; Garetto, Stefano; Palomba, E; Riva, C.; Vierucci, A; Luca, Marcello De; Farina, Salvatore; Fundarò, C.; Genovese, Orazio; Mereu, Giovanna; Forni, Gian Luca; Casadei, A. M.; Zuccotti, Gian Vincenzo; Riva, Enrica; Cellini, Monica; Baraldi, Carlotta; Consolini, Rita; Palla, G.; Ruggeri, Maurizio; Ciccimarra, F; Guarino, Alfredo; Osimani, Patrizia; Benaglia, G; Romano, Amelia; Mattia, Domenico De; Caselli, Desireé; Boni, Silvia; Dell'Erba, G.; Bassanetti, F.; Sticca, M; Timpano, C.; Magnani, Corrado; Casari, Salvatore; Lipreri, Rita; Tornaghi, R; Pinzani, Raffaella; Cecchi, M; Bezzi, T M; Battisti, Luca; Bresciani, Emanuela; Gattinara, Guido Castelli; Nasi, Cíntia; Pellegatta, A.; Mazza, Antonio; Baldi, Federica; Altobelli, R; Deiana, Michela; Colnaghi, C.; Tarallo, Léa; Tondo, U. Di; Anastasio, Elisa; Chiriacò, P. G.; Ruggeri, C.; Scott, Gwendolyn B.; Hutto, Cecelia; O'Sullivan, M. J.; Malmsberry, A.; Willoughby, Anne; Burns, David; Goedert, James J.; Landesman, Sheldon; Minkoff, Howard; Mendez, Herman; Holman, Susan; Rubinstein, Arye; Durako, Steve; Muenz, Larry R.; Goodwin, Sarah; Yj, Bryson; Dillon, Maryanne; Nielsen, Karin; Boyer, Pamela; Liao, Danying; Keller, Margaret; Deveikis, Audra; Nesheim, Steven; Lindsay, Michael; Lee, F.; Nahmias, André J.; Sawyer, Mary K.; Vink, Peter; Farley, John; Alger, Lindsay S.; Abrams, Elaine J.; Bamji, Marukh; Lambert, Genevieve; Schoenbaum, Ellie E.; Thomas, Pauline; Weedon, Jeremy; Palumbo, Paul; Denny, Thomas N.; Oleske, James M.; Bulterys, Marc; Simonds, R. J.; Ethier-Ives, J.; Rogers, Martha F.; Schluchter, Mark D.; Kutner, Michael; Kaplan, Samuel; Kattan, Michael W.; Lipshultz, Steven E.; Mellins, Robert B.; Shearer, William T.; Sopko, George; Sloand, Elaine M.; Wu, Mingfen; Kind, Christian; Nadal, David; Rudin, Christoph; Siegrist, Claire‐Anne; Wyler, Claire-Anne; Cheseaux, Jean‐Jacques; Aebi, Christoph; Gnehm, Hanspeter E.; Schubiger, Gerold; Klingler, Jéromine; Hunziker, U. A.; Kuchler, H.; Gianinazzi, Micòl E.; Buhlmann, Ulrike; Biedermann, K; Lauper, Urs; Irion, Olivier; Brunelli, Alessandro; Spoletini, Gabriele; Schreyer, Alain; Hösli, Irène; Saurenmann, Elisabeth; Drack, G.; Isenschmid, M.; Poorbeik, M.; Schüpbach, Jörg; Perrin, Luc; Erb, Peter C.; Joller, Helen; Kovács, Andrea; Stek, Alice; Chan, Linda S.; Khoury, Margaret M.; Díaz, Clemente; Pacheco-Acosta, Edna; Tuomala, Ruth; Cooper, Ellen; Mesthene, D.; Pitt, Jane; Higgins, A.; Moroso, G; Rich, Kenneth; Turpin, D.; Cooper, N; Davenny, Katherine; Thompson, Bruce; Andiman, Warren A.; Simpson, J. M.

doi:10.1097/00002030-200102160-00009

Cited by 116 publications

(16 citation statements)

References 25 publications

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“…Women with advanced degrees of imunossupression (CD4 < 350 or AIDS) had a significantly higher risk of transmitting HIV to their newborns, similarly to results found in literature [4-7,24]. …”

Section: Discussionsupporting

confidence: 87%

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Mother-to-child transmission of human immunodeficiency virus in aten years period

et al. 2011

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Objectivesto evaluate mother-to-child transmission (MTCT) rates and related factors in HIV-infected pregnant women from a tertiary hospital between 2000 and 2009.Subjects and methodcohort of 452 HIV-infected pregnant women and their newborns. Data was collected from recorded files and undiagnosed children were enrolled for investigation. Statistical analysis: qui-square test, Fisher exact test, Student t test, Mann-Whitney test, ANOVA, risk ratio and confidence intervals.ResultsMTCT occurred in 3.74%. The study population displayed a mean age of 27 years; 86.5% were found to have acquired HIV through sexual contact; 55% were aware of the diagnosis prior to the pregnancy; 62% were not using HAART. Mean CD4 cell-count was 474 cells/ml and 70.3% had undetectable viral loads in the third trimester. HAART included nevirapine in 35% of cases and protease inhibitors in 55%; Zidovudine monotherapy was used in 7.3%. Mean gestational age at delivery was 37.2 weeks and in 92% by caesarian section; 97.2% received intravenous zidovudine. Use of AZT to newborn occurred in 100% of them. Factors identified as associated to MTCT were: low CD4 cell counts, elevated viral loads, maternal AIDS, shorter periods receiving HAART, other conditions (anemia, IUGR (intra uterine growth restriction), oligohydramnium), coinfecctions (CMV and toxoplasmosis) and the occurrence of labor. Use of HAART for longer periods, caesarian and oral zidovudine for the newborns were associated with a decreased risk. Poor adhesion to treatment was present in 13 of the 15 cases of transmission; in 7, coinfecctions were diagnosed (CMV and toxoplasmosis).ConclusionUse of HAART and caesarian delivery are protective factors for mother-to-child transmission of HIV. Maternal coinfecctions and other conditions were risk factors for MTCT.

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Section: Discussionsupporting

confidence: 87%

“…Premature rupture of membranes followed by vaginal delivery was present in one case of newborn infection, confirming it as a collaborating factor for MTCT [24,35]. …”

Section: Discussionmentioning

confidence: 99%

Mother-to-child transmission of human immunodeficiency virus in aten years period

et al. 2011

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“…One such evidence was unveiled in 2001 by The International Perinatal HIV Group. They showed that, the risk of perinatal HIV transmission increases by 2% with every 1-hour increase in the duration of membrane rupture before delivery in HIV-infected women regardless of whether women receive a mono or combination antiretroviral therapy [15]. Other authorities have, however, raised counter arguments that women infected with HIV might suffer increased morbidity and mortality with Caesarean sections such as delayed wound healing, high fevers, severe anemia, infections and a need for additional surgery [16].…”

Section: Introductionmentioning

confidence: 99%

Reproductive rights and options available to women infected with HIV in Ghana: perspectives of service providers from three Ghanaian health facilities

Laar

2013

BMC Women's Health

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BackgroundOwing to improved management of HIV and its associated opportunistic infections, many HIV-positive persons of reproductive age are choosing to exercise their right of parenthood. This study explored the knowledge of health workers from two Ghanaian districts on the reproductive rights and options available to HIV-positive women who wish to conceive.MethodsFacility-based cross-sectional in design, the study involved the entire population of nurse counselors (32) and medical officers (3) who provide counseling and testing services to clients infected with HIV. Both structured and in-depth interviews were conducted after informed consent.ResultsTwo main perspectives were revealed. There was an overwhelmingly high level of approbation by the providers on HIV-positive women’s right to reproduction (94.3%). At the same time, the providers demonstrated a lack of knowledge regarding the various reproductive options available to women infected with HIV. Site of facility, and being younger were associated with practices that violated client’s right to contraceptive counseling (p < 0.05) in each case. Some of the providers openly expressed their inability to give qualified guidance to HIV-positive women on the various reproductive options.ConclusionsTaken together, these findings suggest that many HIV-positive clients do not receive comprehensive information about their reproductive options. These findings highlight some of the problems that service providers face as HIV counselors. Both service providers and policy makers need to recognize these realities and incorporate reproductive health issues of HIV-persons into the existing guidelines.

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“…Factors associated with mother-to-child transmission of HIV in the medical literature include high HIV viral load (>1000 copies/mL), rupture of membranes > 4 hours, low CD4 count, chorioamnionitis, instrumentation during delivery and preterm birth (17, 18, 19, 20). …”

Section: Discussionmentioning

confidence: 99%

Missed Opportunities for Prevention of Mother-to-Child Transmission of Human Immunodeficiency Virus

Scott

Brogly

Muenz

et al. 2017

Obstetrics &Amp; Gynecology

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Duration of ruptured membranes and vertical transmission of HIV-1: a meta-analysis from 15 prospective cohort studies

Abstract: These results support the importance of duration of ruptured membranes as a risk factor for vertical transmission of HIV and suggest that a diagnosis of AIDS in the mother at the time of delivery may potentiate the effect of duration of ruptured membranes.

Cited by 116 publications

References 25 publications

Mother-to-child transmission of human immunodeficiency virus in aten years period

Mother-to-child transmission of human immunodeficiency virus in aten years period

Reproductive rights and options available to women infected with HIV in Ghana: perspectives of service providers from three Ghanaian health facilities

Missed Opportunities for Prevention of Mother-to-Child Transmission of Human Immunodeficiency Virus

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