Duration of Postoperative Fibrinolysis after Total Hip or Knee Replacement: A Laboratory Follow-up Study

Perioperative Factors and Their Effect on the Fibrinolytic System in Arthroplasty Patients

“…In the current study, the results in regard to D-dimer are consistent with literature. 19 Blanié et al 19 found increased D-dimer levels 18 hours postoperatively in patients who had undergone TKA or THA when compared to preoperative values. However, the increased Ddimer levels were not observed at 6 hours postoperatively in patients who had received TXA during surgery.…”

Administration of Tranexamic Acid Reduces Postoperative Blood Loss in Calcaneal Fractures: A Randomized Controlled Trial

“…For patients with multiple injuries or badly controlled chronic disease, the blood loss from surgery to treat a calcaneal fracture can aggravate a patient's general conditions and increase the possibility of blood transfusion. The mechanism of bleeding during and after surgery has mainly been supposed to be increased fibrinolysis activity (18). As an antifibrinolytic lysine analog, TXA binds to plasminogen and plasmin, the central enzyme in fibrinolysis.…”

The effect of tranexamic acid on blood coagulation in total hip replacement arthroplasty: rotational thromboelastographic (ROTEM®) analysis

“…In addition, significant regional fibrinolysis has been reported during femoral implantation [16], and postoperative fibrinolysis peaked at 6 h following surgery and was maintained for up to 18 h after THR [1]. Fibrinolysis is detected by ROTEM as lysis of the clot, which is defined as the maximum lysis over 15%, or better clot formation in APTEM as compared with EXTEM, which presents as a shorter CFT and a greater MCF in APTEM than in EXTEM [17].…”

“…Total hip replacement arthroplasty (THR) often causes considerable blood loss during surgery, and is also complicated by fibrinolysis that continues through the postoperative period [1]. Hydroxyethyl starch (HES), a colloid solution, has been effectively used to treat hypovolaemia resulting from acute surgical bleeding.…”